Mummery Lab@MummeryLab

Cardiovascular development & disease | Stem Cell Biology | Cardiac Organoids | Organ-on-Chip | @GlobalLUMC| @RENEW_Global. Tweets by group members.

 Leiden, The Netherlands
Joined August 2022
🚨Preprint alert! STRAIGHT-IN Dual allows the generation of homogenous genetically-modified hiPSCs β–ͺ️ Done in 1 week with ~100% efficiency β–ͺ️ Markerless and near-scarless approach performed in >10days in a single-well β–ͺ️ Carrying not one but two (single-copy) payloads See🧡below!
Katie Galloway
@GallowayLabMIT
18 Oct 2024
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? 🚨Introducing STRAIGHT-IN Dual! 🧡 (1/n) Link: biorxiv.org/content/10.1101/…
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Katie Galloway
@GallowayLabMIT
May 1
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧡 (1/n)
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Our STRAIGHT-IN Dual platform is officially out at @natBME πŸ”₯πŸš€ A big step forward for programmable stem cell engineering β€” faster, cleaner, and more versatile. LinkπŸ“°: nature.com/articles/s41551-0… Don’t miss the 🧡 from the one and only @GallowayLabMIT breaking it all down πŸ‘‡

STRAIGHT-IN Dual: a platform for dual single-copy integrations of DNA payloads and gene circuits...

Nature Biomedical Engineering - STRAIGHT-IN Dual enables allele-specific integration of two DNA constructs into hiPSCs within 1 week. The system was used to programme hiPSCs into distinct cell...

nature.com
Katie Galloway
@GallowayLabMIT
Apr 30
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? Come hear about STRAIGHT-IN Dual now out at Nature Biomedical Engineering! 🧡 Link at end!
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🚨We have updated our STRAIGHT-IN Dual preprint! 🧡with all the details in the comments (1/n) Link: biorxiv.org/content/10.1101/… @GallowayLabMIT @nbwang22 @BenBlakeleyJ @annionna

STRAIGHT-IN Dual: a platform for dual, single-copy integrations of DNA payloads and gene circuits...

Targeting DNA payloads into human (h)iPSCs involves multiple time-consuming, inefficient steps that must be repeated for each construct. Here, we present STRAIGHT-IN Dual, which enables simultaneous,...

biorxiv.org
Katie Galloway
@GallowayLabMIT
18 Oct 2024
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? 🚨Introducing STRAIGHT-IN Dual! 🧡 (1/n) Link: biorxiv.org/content/10.1101/…
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How do cells transit from fate to fate? Quietly. @MITChemE
bioRxiv SysBio@biorxiv_sysbio
26 Nov 2024
Cells transit through a quiescent-like state to convert to neurons at high rates biorxiv.org/cgi/content/shor… #biorxiv_sysbio
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New career goal unlocked: βœ… Attending the #SynBio24 conference with my twin brother @marcblanch94. Thanks @GallowayLabMIT @billerbeck_s @ProfTomEllis and Yasunori for the amazing program and opportunity to present my last preprint STRAIGHT-IN Dual ⬇️ biorxiv.org/content/10.1101/…
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artxscience 2024 #5 - reNEW Vote for picture #5. ⁦@BenBlakeleyJ⁩ renew.science/artxscience/ar…

artxscience 2024 #5 - reNEW

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renew.science
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What characteristics should an MPS have to be useful for modeling human phenotypes? In this review, we (mainly @dennisnahon & @MoerkensRenee) created a reference for quantifiable 'design' and 'emerging' MPS features to compare to real human settings. nature.com/articles/s41551-0…

Standardizing designed and emergent quantitative features in microphysiological systems

Nature Biomedical Engineering - This Perspective discusses the need for standards that allow for comparisons of quantitative physiological features in microphysiological systems and humans.

nature.com
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Ben Johnson@BenBlakeleyJ
7 Sep 2024
Super thrilled to be part of the reNEW #ARTxSCIENCE competition! Choose your favorite image (obviously mine πŸ˜‰) showing some exciting new work happening with another postdoc and myself! renew.science/artxscience/#a… #LUMC @MummeryLab #cardioid #confocal #stemcell #cardiac
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Extremely happy to see the protocol manuscript for the STRAIGHT-IN platform out online and featured as protocol of the week @NatureProtocols.
Nature Protocols@NatureProtocols
3 Sep 2024
#FeaturedProtocol this week is for STRAIGHT-IN: a platform for rapidly generating panels of #geneticallymodified #humanpluripotentstemcell lines bit.ly/3yJXlVP @A_BlanchAsensio
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reNEW
@reNEW_Global
11 Jul 2024
Join Professor Christine Mummery (@MummeryLab), #reNEW Leiden @LUMC_Leiden, for a panel discussion at #ISSCR2024 on 'Use of Standards for Stem Cells in Non-Clinical Research' on Fri 12 July, 1.30pm-3.00pm CEST in Hall G2, Level 2.
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Happy to see our work highlighted at The Scientist magazine. Targeted Gene Integration for High-Throughput Applications the-scientist.com/targeted-g…

Targeted Gene Integration for High-Throughput Applications | The Scientist

A new approach using two types of recombinases lets scientists insert larger DNA payloads into human pluripotent stem cells faster than ever before.

the-scientist.com
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Jim Wells Lab@JimWellsLab
4 Apr 2024
Kicking off the last session of Day 1 #ISSCRCincy is @MummeryLab with a fantastic update on her work on hpsc-derived cardiovascular tissue to study disease. @ISSCR
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reNEW
@reNEW_Global
20 Mar 2024
We are pushing stem cell research further than ever before. Meet Professor Christine Mummery. Her work focuses on understanding cardiovascular development and disease mechanisms.​ All reNEW researchers are leaders within their field, with a strong track record of scientific excellence. Together, they work to turn their research into real therapies that improve the health of people around the world. See full video: renew.science/principal_inve… @GlobalLumc @MummeryLab @MCRI_for_kids @UCPH_Research #stemcellresearch #stemcelltherapies #cardiovasculardevelopment
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reNEW
@reNEW_Global
15 Mar 2024
Congratulations to postdoc Ben Johnson, from the Richard Davis and @MummeryLab at reNEW Leiden for receiving a prestigious Marie Curie fellowship. Ben will use the fellowship to develop a stem cell based model for myocardial infarctions. Read more: renew.science/stories/marie-…
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Katie Galloway
@GallowayLabMIT
8 Mar 2024
Delighted to welcome Albert Blanch Asensio @A_BlanchAsensio as a visiting student with our lab! Albert pioneered STRAIGHT-IN with Richard Davis and @MummeryLab. We're excited to build circuits in these landing pad iPSC lines! tinyurl.com/snhjesjw
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🧐 #MeetTheSpeaker! πŸ”¬ @MummeryLab @LUMC_Leiden explores the potential of #iPSCs in disease modeling. From mimicking patient mutations to screening for drugs, the goal is to create a population study for personalized medicine. piped.video/a13QH7CM-pc
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Cell Reports@CellReports
9 Jan 2024
Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes dlvr.it/T18sgJ
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Ben Johnson@BenBlakeleyJ
10 Jan 2024
Thrilled to be awarded the NWO-XS grant to generate an inducible heart attack stem cell model in a fantastic lab! ⁦@MummeryLab⁩ ⁦@reNEW_Global⁩ linkedin.com/posts/novo-nord…

𝐀 𝐬𝐑𝐨𝐭 𝐭𝐨 𝐭𝐑𝐞 𝐑𝐞𝐚𝐫𝐭 - π†π«πšπ§π­ 𝐟𝐨𝐫 𝐧𝐞𝐰 𝐬𝐭𝐞𝐦 𝐜𝐞π₯π₯ π›πšπ¬πžπ 𝐑𝐞𝐚...

𝐀 𝐬𝐑𝐨𝐭 𝐭𝐨 𝐭𝐑𝐞 𝐑𝐞𝐚𝐫𝐭 - π†π«πšπ§π­ 𝐟𝐨𝐫 𝐧𝐞𝐰 𝐬𝐭𝐞𝐦 𝐜𝐞π₯π₯ π›πšπ¬πžπ 𝐑𝐞𝐚𝐫𝐭 𝐚𝐭𝐭𝐚𝐜𝐀 𝐦𝐨𝐝𝐞π₯ πŸŽ₯ A patch of genetically modified cardiomyocytes that contain a 'kill...

linkedin.com
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The true #vascular meets #cardiac: it's going to be an awesome conference! Looking forward to it. Mark your calendars!πŸ—“οΈ #Cardiovascular @UofT_LMP @bme_uoft @UHN_Research @TGHRI_UHN @vascularbiology
EMBL Events
@EMBLEvents
29 Aug 2023
Join the new EMBO Workshop 'The new cardiobiology' and deepen your understanding of the causes and early development of cardiovascular disease.πŸ«€ πŸ“©Β Submit abstract by 28 November ➑️ s.embl.org/ncb24-01 #EMBOCardioBiology #EMBOCardioBiology Scientific organisers are: @PilarAlcaidePhD, @JohannesBacks, @TinaHaase3 and @PorrelloER.
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