Bioinformatician | BiffiLab @CRUK_CI @Cambridge_Uni @DarwinCollege 🇮🇶🇹🇷🇬🇧

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🚨Happy to share with you our Lab’s latest #BioRxiv pre-print. 🥳 TGF-β- and IL-1-dependent fibroblast states differentially shape pancreatic cancer microenvironments and metastasis biorxiv.org/content/10.64898… A huge amount of work (and 🐭 breedings!). Hope you enjoy the read!
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Congratulations to @BiffiGiulia, @Wenlong_Li1, and @Munta04 for their article published in @NatureCellBio! 🥳 Read how they developed multi-stromal #organoid co-culture models to explore fibroblast and epithelial cell interactions in #PancreaticCancer and #Pancreatitis 👉 go.nature.com/46NvfGl
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My "co-first" paper with dear @Wenlong_Li1 is now out in @NatureCellBio. Big thank to @BiffiGiulia, the whole biffi lab, @pauldwkirk and all co authors.
🥳Happy to share our latest manuscript - out today in @NatureCellBio. 💜 Congrats and thanks to @Wenlong_Li1 and @Munta04, the whole lab, our collaborators and the funders that supported this important and beautiful 🤩 work! Hope you enjoy the read! nature.com/articles/s41556-0…
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#PancreaticCancer, your days are numbered with this #team. 💜
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Join us in London in July next year!
Details of the inaugural @CR_UK #PancreaticCancer conference to be held in London (7-9 July 2026) below. Early bird registration closes on Jan 9. Abstract submission deadline March 15. cancerresearchuk.org/for-res… Share widely and hope to see you all there! 🇬🇧
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Excited to share our latest #PrePrint 🎉 biorxiv.org/content/10.6... We wanted to understand how epithelial cell-fibroblast crosstalk is distinct in #PancreaticCancer and #Pancreatitis. This took us on a (long...) journey...have a read! Congrats to Wenlong and Munta. 💜
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Going from biotech to tech was an unexpectedly humbling experience, almost an egodeath. In biotech, doing bioinformatics during a PhD or postdoc is considered highly technical, you’re the “computer person” in a world of wet-lab scientists. But in tech, that experience doesn’t carry the same weight. If you haven’t trained a billion-parameter model or built a platform from scratch, you’re not seen as “technical” enough. The shift kinda forces you to rethink what being “technical” really means. Or perhaps we're in this bay area bubble of accusing each other of not being 'technical enough' till death takes us.
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We are seeking an experienced Bioinformatician to lead data analysis for a new research group. If you have a passion for working with large-scale genomics datasets and a deep understanding of biological principles, please apply. cam.ac.uk/jobs/bioinformatic…
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Can't agree more ..
Uh oh: deep learning models in genomics lose badly to very simple linear models. Could they have been over-hyped? (new paper by @s_anders_m @const_ae and Wolfgang Huber) nature.com/articles/s41592-0…
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For biological data, if you don't have deep expertise in this low value work called data cleaning, u r lacking a fundamental understanding of the idiosyncrasies of the data. Without this knowledge, it is impossible to seriously model data.
Academia must be the only industry where extremely high-skilled PhD students spend much of their time doing low value work (like data cleaning). A 1st year management consultant outsources this immediately. Imagine the productivity gains if PhDs could focus on thinking
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🎉New research grant awarded by @PancreaticCanUK! @BiffiGiulia Group @CRUK_CI will work with @Gilbertson_Lab to explore how cancer cells communicate within #TumourMicroenvironment to promote growth in #PancreaticCancer & #LungCancer. Read more👉cambridge-pcc.org/Press_rele…
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🎉Huge congratulations to @Debi_Mukh @BiffiGiulia Group @CRUK_CI for being awarded the @MSCActions Postdoctoral Fellowship! She will explore how cancer-associated fibroblasts (CAFs) contribute to #Cachexia in #PancreaticCancer. Read more👉cambridge-pcc.org/Press_rele…
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🎉Huge congratulations to #WenlongLi @BiffiGiulia @CRUK_CI who has been awarded @CR_UK #ACED_EarlyCancer fellowship to uncover new biomarkers🎯 in fibroblasts for #EarlyDetection of #PancreaticCancer Read more👉cambridge-pcc.org/Press_rele…
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🎉 Scanpy 1.11.0 is out! 🎉 just after reaching 2000 stars on GitHub! - sc.pp.sample replaces subsample with many new features - Sparse Dask support pca - session-info2 package for more reproducible notebooks See the release notes: buff.ly/4gJJSNv
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So excited and happy for @eloise_g_lloyd 👏🎊
🥳Happy to see @eloise_g_lloyd et al finally published! A beautiful study looking at how distinct #genetics of malignant cells shape #PDACprogression, #TMEcomposition and #TherapyResponse. 👇 aacrjournals.org/cancerres/a… Also, for future posts see you on 🦋 @giuliabiffi.bsky.social
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A review to get you talking! 💬 @Pris_Cheng, Marta Zaccaria, and Dr. @BiffiGiulia discuss recently identified functional interactions of #CAF subtypes with immune cells, and other stromal cells in primary tumors and metastases. @CRUK_CI 📚 bit.ly/4gAPbz8
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A really comprehensive fibroblast review in primary and metastatic cancers! In @trendscancer from @BiffiGiulia @marta_zaccaria_ @Pris_Cheng Wonderful job! Illustrations below highlighting (A) Cues that contribute to fibroblast heterogeneity in cancer (B) Fibroblast Cancer cell crosstalk (C) Fibroblast Immune cell crosstalk (D) Fibroblast Stromal cell crosstalk Link to manuscript below. @CR_UK @CRUKresearch
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🚨2024 is coming to a close but #research on #fibroblast_functions in #cancer is far from done ✅. If you want to know more, read our latest #review now in press @trendscancer. Fantastic job by @Pris_Cheng and @marta_zaccaria_ 🌟👏🏻. And happy 2025 🫶 sciencedirect.com/science/ar…
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Our Plant & Bake Sale @CRUK_CI is ready to go! Come and support us to raise fund for @PancreaticCanUK and @CR_UK !
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