The Nogales Lab@NogalesLab

The Nogales Lab at UC Berkeley. #CryoEM #Transcription #Microtubules #ChromatinModification #Telomerase Twitter account managed by lab members.

 Berkeley, CA
cryoem.berkeley.edu/
Joined January 2019
127 Photos and videos
Thrilled to share our latest work, led by @aryandtaheri and @jpeukes! Using #cryoEM and #cryoET, we reveal how KIF21B’s distal tail engages multiple tubulin dimers along a protofilament, enabling persistent microtubule attachment and crosslinking. biorxiv.org/content/10.64898…
2
7
45
2,282
Thrilled to share our collab with @GraceHibshman and the Shipman lab! Type IX retron-Kva2 structure reveals phage detection via an HTH fold, not a primary sequence. We computationally designed triggers that program bacteria cell death, pointing toward designer antimicrobials.
2
25
84
8,400
biorxiv.org/content/10.64898…

Higher-order assembly of a type IX retron enables exploitation for designer antimicrobials

Bacterial defense systems provide a rich reservoir for biotechnological innovation. Retrons are tripartite abortive infection systems that detect phage invasion using reverse-transcribed DNA (msDNA),...

biorxiv.org
1
1
8
734
🧵 New paper alert! Today on bioRxiv, we show how a microtubule (MT) associated protein, MTCL1, links 2 regulatory layers: mechanical MT stabilization and writing of then tubulin code. A multi-lab effort driven by @Juanmabertoldi1 and Julie Dang spanning atoms to organisms. 1/n
1
14
42
3,565
more replies
Full text here: biorxiv.org/content/10.64898… @Juanmabertoldi1, Julie Dang, Mert Golcuk, Eva Lanska, @lopesdanilo11, Veronique Henriot, Jingyi Luo, @RuiZhangWUSTL, @JeffTiLab, @CarstenJanke, Zdenek Lansky, @PittGurLab, @filodelbene, @NogalesLab 10/n

Coupling of tubulin acetylation to microtubule stabilization through molecular mimicry

Microtubules support diverse cellular functions through regulation by microtubule-associated proteins and tubulin post-translational modification, yet how these two layers are mechanistically...

biorxiv.org
2
1
4
382
#microtubules #cryoEM #tubulincode #cellbiology #neuroscience #zebrafish #structuralbiology #biorxiv 11/n
250
Molecular imaging pioneer Eva Nogales awarded the 2026 Vanderbilt Prize in Biomedical Science news.vumc.org/2026/06/30/mol… I am truly honored to receive this prize and incredibly grateful to have worked with so many talented lab members over the years.🙏👩‍🎓🧑‍💼

Molecular imaging pioneer Eva Nogales awarded the 2026 Vanderbilt Prize in Biomedical Science

The Vanderbilt Prize in Biomedical Science recognizes scientists who have a stellar record of research accomplishments.

news.vumc.org
4
11
77
4,813
Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study! biorxiv.org/content/10.64898…
1
8
40
4,163
Congrats to Ana Galic and Kevin Li, who just graduated with honors in MCB, and to the brand new Dr. Trinity Cookis @trincookis 👨‍🎓👩‍🎓👩‍🎓🤩. Very best wishes for your next endeavors 💝.
2
2
29
2,022
@berkeleyMCB
1
1
351
Congrats to my @berkeleyMCB colleague @AndyMartinLab who just received the Dorothy Crowfoot Hodgkin Award of the @ProteinSociety. Andy's studies have made the proteasome one of the best understood molecular machines in biology. Well deserved!! 🥳🥳
1
13
974
Another fabulous PEW meeting, this year at Palm Springs. So lovely to share time with both exlab members @vignesh_k757 and @kellogg_liz and @UCBerkeley colleagues. LatinAmericanFellows, please send me photos by email! Science was simply wonderful!! 🧬🥇
5
59
7,450
Load more