Molecular pharmacologist and GPCR enthusiast, somewhat disillusioned. We also dabble in structural biology. All posts are my own.
Melbourne, Victoria
- Tweets 4,159
- Following 132
- Followers 1,010
- Likes 9,051
Patrick M Sexton retweeted
Seminar alert! ⏰We welcome Dr Bronte Johnstone, Research Fellow, Ghosal Laboratory, Bio21 Institute, University of Melbourne. “Utilising cryo-EM and cryo-ET to investigate host-pathogen interactions mediated by membrane molecular machines” . More info: ccemmp.org/events/ccemmp-sem…
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Patrick M Sexton retweeted
Happy to share this review @jbiolchem. Some discusion about constitutively active orphan GPCRs and the role of cryo-em as a tool to help receptor de-orphanization.
jbc.org/article/S0021-9258(2….
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Patrick M Sexton retweeted
I’m delighted to share that I have been promoted to Professor of Cell Biology at Imperial College London. I am deeply grateful to those who have supported me along the way, through the many ups and downs that led to this point.
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Patrick M Sexton retweeted
📢Research Symposium - Nov 13 & 14, 2025 at Bio21 - Posters & oral presentations - Keynote speakers Wai-Hong Tham (WEHI/ANU) & Alastair Stewart (VCCRI). More details ccemmp.org/events/arc-ccemmp… @arc_gov_au @WEHI_research @Bio21Institute @MIPS_Australia @UOW
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Patrick M Sexton retweeted
For readers interested in the growing therapeutic applications for GLP-1 based drugs such as semaglutide and tirzepatide, here's a comprehensive review by @DanielJDrucker in the August issue
nature.com/articles/s41573-0…
rdcu.be/eBVB4
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Patrick M Sexton retweeted
Happy to share structures of kainate receptor channel GluK2 in complex with auxiliary subunits Neto2, which slow receptor kinetics, in apo closed and open conducting states, both with 2-fold symmetrical LBD layer! @shantigangwar @MariaKarela3 @LauraYen42
nature.com/articles/s41594-0…
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Patrick M Sexton retweeted
"My interest in science probably grew out of my interest in becoming a physician."
In his biography, 2012 chemistry laureate Brian Kobilka tells us about his scientific journey and how his interest in science started at an early age.
Read his bio here: nobelprize.org/prizes/chemis…
ALT Brian Kobilka smiles while seated at a desk in an office, with a molecular model structure and various books on the desk. Behind the individual, a computer screen and a sports jersey with "KOBILKA 1" written on it can be seen.
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Patrick M Sexton retweeted
🔉 Only a few days left to vote! 🔉
Our 2nd CCeMMP Annual Bench to Art Competition gallery is LIVE! 🤩
ccemmp.org/events/arc-ccemmp…
Vote, like and repost :)
#membraneproteins
#scicomm
#nationalscienceweek
#cryoEM
#cryoET
🥳Our 2nd @arc_gov_au CCeMMP Bench to Art gallery is now LIVE! Each submission offers a unique + creative take on research!
🖼️ Explore the gallery here: ccemmp.org/events/arc-ccemmp…
And help us crown the People's Choice winner by casting your vote🗳️
#nationalscienceweek
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Patrick M Sexton retweeted
Our collaborative work on the T9SS is just out in Nature Communications! Fantastic work led by Dhana Gorasia and Eric Hanssen. This paper reveals the structure of the T9SS outer membrane PorKN ring complex and mechanistic insights into protein secretion. nature.com/articles/s41467-0…
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Patrick M Sexton retweeted
Thanks for an awesome seminar yesterday Prof. Dimitrios Fotiadis (Univ Bern)👏👏. Missed it..?? Check it out here 👉ccemmp.org/ccemmp-special-se… @arc_gov_au @MIPS_Australia @WEHI_research @Bio21Institute @UOW
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Patrick M Sexton retweeted
Amylin and calcitonin differentially affected AMYR subunit assembly and disassembly in a RAMP-specific manner science.org/doi/10.1126/scis…
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Patrick M Sexton retweeted
Seminar time⏲️ We welcome Professor Dimitrios Fotiadis, IBMM, Medical Faculty, University of Bern: “Structural and mechanistic insights into transmembrane glucose transport and light-driven proton pumping” 🥳More info: ccemmp.org/events/ccemmp-sem…
@arc_gov_au
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Patrick M Sexton retweeted
🥳Our 2nd @arc_gov_au CCeMMP Bench to Art gallery is now LIVE! Each submission offers a unique + creative take on research!
🖼️ Explore the gallery here: ccemmp.org/events/arc-ccemmp…
And help us crown the People's Choice winner by casting your vote🗳️
#nationalscienceweek
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Patrick M Sexton retweeted
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I am excited to share our study describing a new modality of #intracrine #signalling by a #metabolite-sensing #GPCR published today with @SpringerNature in @NatChemBiol! @UoB_MSS @COMPARE_UoBUoN @UoBmedicalsci @unibirm_CMH
nature.com/articles/s41589-0…
🧵👇
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Patrick M Sexton retweeted
Check out this new study describing a new modality of #intracrine #GPCR #signalling led by our @DavideCalebiro lab @COMPARE_UoBUoN with Shannon O’Brien as first author!
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I am excited to share our study describing a new modality of #intracrine #signalling by a #metabolite-sensing #GPCR published today with @SpringerNature in @NatChemBiol! @UoB_MSS @COMPARE_UoBUoN @UoBmedicalsci @unibirm_CMH
nature.com/articles/s41589-0…
🧵👇
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Patrick M Sexton retweeted
Only 48 hours left to submit your image for our ARC CCeMMP 2nd Annual Bench to Art Exhibition 2025!🤯 ⏲️Share your stories of exploration and discovery in structural biology with the broader community and win cash prizes 💰Submit your entry/more info here: ccemmp.org/events/arc-ccemmp…
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Patrick M Sexton retweeted
Wonderful collaboration with Sigal Ben-Yehuda lab! Our PhD student @SomavallyD, who just had her superb thesis oration drove the high-resolution imaging part of the project. ❄️ 🦠 🔬 🧬
@UniMelb @CCeMMP @UniMelbMDHS @Bio21Institute
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Patrick M Sexton retweeted
Design of linear and cyclic peptide binders from protein sequence information
nature.com/articles/s42004-0…
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Patrick M Sexton retweeted
Less than 2 weeks to go! 🤯Mare sure you prepare your entries for our 2nd @arc_gov_au CCeMMP 'Bench to Art' Exhibition during National Science Week & win cash prizes 💰! Please like & share 🫰 More info: ccemmp.org/events/arc-ccemmp…
#CryoEM
#CryoET
#MembraneProtein
#GPCR
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Patrick M Sexton retweeted
We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed!
nature.com/articles/s41467-0…
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