Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7) cell.com/cell/fulltext/S0092…

We are recruiting new faculty at all levels who seek to solve fundamental problems in biology and disease. @CRI_UTSW is an exceptional and highly collaborative environment to build a research program and pursue ambitious science. Join us!

😊 New preprint! In budding yeast, Dna2-intrinsic condensation regulates long-range DNA-end resection. Analyses suggest redistribution of condensate grammar in humans. Congrats to Chris Jordan and the Mekhail, Wyatt, Cowen & Hakem labs! More to come soon. biorxiv.org/content/10.64898…

A big week for the lab! Two new papers on how cells repair DNA double-strand breaks: one on getting NHEJ started in chromatin, one on processing the ends before ligation. Years of work by a fantastic team.

New Online! Mechanisms and disease relevance of DNA break repair pathway choice dlvr.it/TVXnnC

How are mitotic chromosomes built? 🏗️ Our Review @TrendsGenetics revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes: authors.elsevier.com/a/1nmwr…

Very happy to share our new Perspective in Nature Reviews Genetics, led and written primarily by my colleague Liam P. Shaw: “The shared evolutionary capacities of plasmids and extrachromosomal DNA” nature.com/articles/s41576-0…

Excited to share our new @ScienceAdvances paper! During interphase, centromeres form 3D shells organized by the CENP-A chaperone complex at their core. Led by Hindol Gupta, with the @TakashiAkeraLab , Losada, and Shroff labs. science.org/doi/10.1126/scia…

🎉 Excited to share the first preprint from the Panday Lab! biorxiv.org/content/10.64898… We identify FANCM as an adaptive genome-maintenance dependency in BRCA1-deficient breast cancer and uncover its role in restraining ongoing structural genome evolution.

How did we come to understand cancer in the light of evolutionary theory? Nothing makes sense if not with population genetics! In our latest @NatureRevCancer review we unpack how population genetics theory applied to somatic cells allows us to measure and predict cancer evolution from molecular data. Computational modelling in oncology has gone a long way but we need to go much further. The frontier is combining evolutionary theory with machine learning. Link below👇

#Postdoc position available in my lab to study the role of senescence and senescence evasion in cancer therapy responses (available for up to 5 years) Check out saurinlab.com further details about project and lab culture in general. jobs.ac.uk/job/DSS226/post-d…

1/ Out today in @Nature! 🧵 We mapped the mutational processes shaping 959 prostate cancer genomes from the Pan Prostate Cancer Group (PPCG), integrating SBS, ID, CX and complex SV signatures. Eight footprints account for the processes in 85% of cases nature.com/articles/s41586-0…

Cool, its finally out. Base editing in human embryos! nature.com/articles/s41586-0…

Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @NatureGenet reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗nature.com/articles/s41588-0… (1/2)

Out in @ScienceMagazine: we found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @Gerlich_Lab, led by @flavia_corsi science.org/doi/10.1126/scie…

Mitotic #genomes have their #chromosomes connected together by #DNA-based linkers with about the same spring constant as the chromos themselves biorxiv.org/content/10.64898… [also the case for 🐁 meiotic metaphase] TY for a great collaboration, Lisa Hua Lab @SSUbiology !

Spindle elongation in cell division can rescue chromosomes straying to the poles so avoiding abnormal chromosome number/cell 📹 @isabella__k & Valentina Štimac et al @Toliclab @institutrb in @NatureComms ➡️ bpod.org.uk/archive/2026/9/4 + @DrJohnAnkers

Interested in nuclear mechanobiology and want to know what some of the big open questions are in the field? Read our recent editorial with input from >15 leading experts in the field, along with a list of review articles on nuclear #mechanobiology: tandfonline.com/doi/full/10.…

In a new Science study, researchers show that chromatin exists as a hydrogel that undergoes a volume phase transition between condensed and uncondensed states that correspond to regions of gene activity and silence, respectively. Learn more in a new #SciencePerspective: scim.ag/4x2vkRX

The Baylor College of Medicine Conference on Structural Variants and DNA Repeats is back, and this year it has a new home! Join us in person in Houston November 19th–20th. Or join online. Virtual registration is FREE! ErwinLab.org/svar-conference