New dates, same ReThink spirit! 🏄 Join us at Weizmann, May 24–26, 2027, for 3 days of bold ideas and lively discussions shaping the future of neuroimmunology. Explore our speakers and register: conferences.weizmann.ac.il/R… #ReThinkNeuroimmunology

Yesterday, the Quintana Lab returned to one of its well-established traditions, running the Boston 5K organized by the @racecancer . Congratulations to all the Quintana Lab members, especially @MiKilian90, who had the fastest time among us! 🏃‍♂️🏃‍♀️

Terrific talk by @JoonHyukLee3 in the BWH ARCND Seminar Series on how astrocytes promote CNS autoimmunity! 🧠👏

Study identifies brain cells that may boost ongoing inflammation in Multiple Sclerosis mgriblog.org/science-insight…

Our new study, led by @JoonHyukLee3 , is out today in @Nature! We discovered a population of CD40+MHC-II+ astrocytes that present antigens to CD4+ T cells, enhancing pathogenic Th17 responses and promoting CNS autoimmunity. nature.com/articles/s41586-0…

🌟 Check out new content @NatureCancer by Francisco Quintana and collaborators 👇 doi.org/10.1038/s43018-025-0…

Giovannoni, Strathdee, and Akl et al. engineered an HSV-1 platform for GBM viroimmunotherapy. Incorporation of EGFR- or integrin-binding gD variants expanded GBM tropism, fusogenic mutations enhanced intratumoral spread, and miRNA attenuation protected healthy CNS tissue. The replication-competent backbone enabled local delivery of IL-12, anti-PD-1, a bispecific T cell engager, HPGD to degrade PGE2, and anti-TREM2 to remodel lymphoid and myeloid compartments. Single intratumoral dosing elicited tumor-specific T cell, NK cell, and myeloid responses, and prolonged survival in aGL261-N GBM model. bit.ly/490r2Qe  @harvardmed  @MGBResearchNews  @QuintanaLabHMS

By reprogramming the tumor microenvironment with an engineered virus, @QuintanaLabHMS boost anti-tumor immunity in a glioblastoma model @NatureCancer. @MGBResearchNews @broadinstitute @harvardmed massgeneralbrigham.org/en/ab…

🙌A huge thanks to the organizers for putting together a brilliant program for #RTN2025 🧠 - @IdoAmitLab @jonykipnis @stevens1lab @RejaneRua @QuintanaLabHMS. Also grateful to our many sponsors, speakers, attendees & vital team behind the scenes for an awesome meeting of the minds

Interested in working cancer immunotherapy research? The Andersen lab is looking for a Research Assistant to work on glioblastoma. More information below:

Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in @Nature today! Congrats to Brian Andersen and @CamiloFaustAkl! nature.com/articles/s41586-0…

New pre-print from our lab here: biorxiv.org/content/10.1101/…

Therapeutic B cell depletion identifies immunoregulatory networks preview @jclinicalinvest @QuintanaLabHMS @carol_zinhap jci.org/articles/view/189442 article @DavidHaflerMD @ppaxisa jci.org/articles/view/182790

Our study on glioblastoma-associated immunoregulatory astrocytes is out in @Nature today by @CamiloFaustAkl! We identified GBM-derived IL-11 as a regulator of TRAIL+ astrocytes, which limit anti-tumor T cell responses via apoptosis. nature.com/articles/s41586-0…

Nature research paper: Psychedelic control of neuroimmune interactions governing fear go.nature.com/4izW8kH

New review on our all-time favorite molecule out today in @NatRevDrugDisc by @carol_zinhap!

A genome-wide CRISPR screen for regulators of astrocyte inflammation identified CLEC16A, linked to MS susceptibility, as a suppressor of NF-κB signaling; CLEC16A promotes mitophagy, and ablating it in astrocytes worsens pathology in an MS model nature.com/articles/s41593-0…

Our study on the protective role of CLEC16A in astrocytes in MS is out today in @NatureNeuro! Congrats to Atsushi and all collaborators! nature.com/articles/s41593-0…

A tour de force review of the connections between the nervous and immune systems @Nature nature.com/articles/s41586-0… @QuintanaLabHMS

Today we all dressed up as our favorite and most consistently dressed scientist: @hong_lee89 Happy Hongloween! 🎃👻