Qué poco estamos hablando de Indonesia y todos los animales que están perdiendo la vida. 💔👇

Fun fact: most Mexicans are more native to America than any white American

I predict we will see a number of new rejuvenation factors in the coming years, but their clinical application in ageing will be challenging. One major obstacle is cancer. Many rejuvenation strategies involve enhancing cellular plasticity, stemness or cell proliferation. While these processes may promote tissue regeneration and repair, they can also increase the risk of tumour development. A fundamental challenge will therefore be finding ways to promote tissue rejuvenation safely and without increasing cancer risk. For more on the evolutionary trade-offs between cancer and ageing, see: nature.com/articles/s41568-0…

Has anyone else noticed that its getting more difficult to type on your phone? Like a definite increase in misspelled words. My wife and sister have noticed it too. Whats causing that?

Most exercise and aging studies can't answer a basic question: is muscle deterioration from aging itself, or just from decades of moving less? A new Nature Aging study solved this by recruiting older adults who moved as much as people in their twenties. The researchers from Amsterdam UMC and Maastricht University recruited four distinct groups: young adults in their twenties, older adults whose daily step counts and high-intensity activity matched the young group, older adults who had trained consistently for years (three structured hour-long sessions per week for over a year), and older adults with early physical impairment. They took muscle biopsies before and after a one-hour cycling session, then measured over 24,000 gene transcripts, 135 metabolites, and 1,383 lipid species. By matching activity levels between young and older groups, any molecular differences couldn't be blamed on the older adults simply moving less. This isolated aging from inactivity for the first time at this molecular depth. Key findings: • The defining molecular signature of muscle aging is an energy crisis. Comparing young adults to activity-matched older adults, 1,106 genes were downregulated with age. These genes build the mitochondrial machinery that produces cellular energy: ATP synthase, cytochrome c oxidase, and NADH dehydrogenase subunits. Mitochondria are the power plants of cells, converting nutrients into ATP, the energy currency cells use to function. When these genes decline, cells lose their ability to generate energy efficiently. • NAD+ levels declined and triglycerides accumulated inside aging muscle. NAD+ is a molecule required for energy production and cellular repair. Lower NAD+ means less capacity to convert fuel into usable energy. Triglycerides are stored fats, their accumulation inside muscle indicates unburned fuel piling up as the tissue loses its ability to process it. • More than half the molecular signature of muscle aging was absent in trained older adults. Specifically, 57.1% of age-related gene downregulation and 55.9% of upregulation were missing in the trained group. Their muscle resembled young adults far more than their chronological age would predict. • The changes training preserved were specifically the energy metabolism ones. Genes like NDUFS1 and COX5A, which were depleted in normally active and impaired older adults, sat at youthful levels in the trained group across all five mitochondrial respiratory complexes. The single most prominent feature of muscle aging turned out to be the single most preventable. • Being generally active was not enough. Structured training was the difference. The normally active older adults walked as much as young adults, and their energy metabolism genes declined anyway. What preserved the youthful molecular profile was structured, sustained training. Filling a step counter and being genuinely trained are not equivalent at the molecular level. • Roughly half of muscle aging persisted regardless of training. Changes in genes controlling synaptic transmission (how nerves communicate with muscle) and WNT signaling (a pathway regulating tissue maintenance and stem cell function) appeared in all older adults, trained or not. This unavoidable half is where drugs will have to work. • The fittest muscle mounted the largest inflammatory response to exercise. All groups activated stress and immune genes after exercise, including IL6, IL1B, and TNF. But the magnitude scaled with fitness. Trained older adults most closely resembled young adults in their response, followed by normally active, with impaired older adults showing the most blunted response. The stress response to exercise appears to be the mechanism of adaptation, not damage to be minimized. This raises a concern about anti-inflammatory longevity strategies. If the inflammatory stress response is how exercise produces its benefits, chronically suppressing inflammation may blunt the adaptation that exercise depends on. It doesn't mean inflammation is beneficial in general, but the timing and context matter. A separate discovery: the proteasome appears to regulate NAD+. The proteasome is the cellular machinery that breaks down damaged proteins. When researchers inhibited it, NAD+ levels rose in both muscle and liver cells to a degree comparable to NAD+ precursor supplements. This opens a new route to understanding NAD+ decline that operates through protein turnover rather than just supplying more raw material. The study draws a clear line between what lifestyle can address and what will require therapeutics. The energy metabolism decline, mitochondrial deterioration, and NAD+ depletion that define muscle aging are largely preventable through structured training. The synaptic and signaling changes that persist in all older adults represent the unavoidable half where drugs will need to work. The decisions made about structured training in midlife determine which molecular trajectory muscle follows in later decades. Half of muscle aging is optional. The other half isn't. Knowing which changes belong to each category is knowing where behavior ends and biology takes over.

No human who has pipetted even a single microliter holds this belief

imagine every decision you've ever made, every person you've met, every twist of fate in your life, all conspiring to put you in the exact wrong place at the exact wrong second, just so a plane can fall out of the sky and hit you

Offensive line porn

I am deeply troubled by what our forecasting model is showing. I have reviewed the numbers seven times, and each time the implications become more disturbing. I now face an ethical dilemma of considerable magnitude: whether the public has a right to information it may not be emotionally equipped to process.

This is a really good chart showing the racial diversity of major U.S. cities.

You’d think more people wouldn’t want to die young wouldn’t you.

This broke me. Find this man. Find him and I will personally fundraise for him.

Kenalan lagi sama salah satu penghuni Taman Nasional Tanjung Puting 🦧 Namanya ROGER, bisa dibilang dia itu "lord" atau bos besarnya orangutan di area Camp Tanjung Harapan, Taman Nasional Tanjung Puting. Profilnya itu legendaris banget di kalangan para ranger hutan dan turis yang sering ke sana. ROGER ADALAH SI PREMAN HUTAN YANG CERDAS 🦧 🦧Roger ini orangutan jantan dewasa dominan. Mukanya punya bantalan pipi (flanges) yang lebar banget, khas cowok alfa, plus ada bekas luka di atas bibirnya. Katanya, tenaganya setara tujuh orang dewasa. Kalau dia sudah lewat, orangutan lain pasti langsung minggir sungkem. 🦧Hobinya hadang kapal logistik. Ini bagian lucunya. Roger itu pintar banget. Dia hapal luar kepala jadwal mingguan kapal yang bawa pasokan buah pisang dari kota. Kadang, dia sengaja jalan kaki ke dermaga wisata cuma buat menghadang kapal logistik itu demi minta jatah pisang. Para ranger sampai harus putar otak buat mengalihkan perhatiannya supaya kapal bisa lewat dengan aman. 🦧Raja yang rajin patroli. Daerah kekuasaannya luas banget. Dalam sehari, dia bisa jalan kaki dan memanjat pohon keliling hutan sampai radius 24 kilometer cuma buat memastikan wilayahnya aman dari gangguan pejantan lain. Masa-Masa Sulit Akibat Kebakaran Hutan 😢 Sayangnya, cerita keren si Roger ini sempat berubah jadi mengharukan waktu kebakaran hutan hebat melanda Tanjung Puting. Roger suka bengong di pohon gosong. Ada video viral yang bikin netizen sedih banget. Roger terekam lagi duduk lemas sendirian di atas dahan pohon yang daunnya habis. Di bawahnya, sejauh mata memandang, cuma ada tanah hitam bekas kebakaran dan asap tebal. Si Raja Rimba yang biasanya gagah kelihatan bingung karena "istananya" habis terbakar. Karena pohon-pohon tempat tinggal dan sumber makanannya ludes, Roger terpaksa turun gunung. Dia dan beberapa orangutan lain sempat terlihat mendekati pos jaga para ranger dan perumahan warga sekitar. Mereka bukan mau menyerang, tapi murni karena kepanasan dan kelaparan mencari tempat berteduh. Gimana Kondisinya Sekarang? Untungnya, Roger nggak sendirian menghadapi masa sulit itu. Para petugas taman nasional dan relawan dari lembaga konservasi (seperti OFI) langsung bergerak cepat. Meskipun kondisi hutan masih berasap, mereka rajin mengantarkan makanan dan buah-buahan ke tempat pemberian pakan (feeding site) supaya Roger dan teman-temannya nggak kelaparan. Kisah Roger ini akhirnya viral dan jadi pengingat buat banyak orang kalau hutan Kalimantan dan penghuninya yang pintar-pintar ini memang harus benar-benar kita jaga bareng-bareng.

"Witnessing such a young elephant lose its life to trophy hunting is a painful reminder of why we cannot allow this to continue.Together, let's demand stricter regulations and an immediate ban on trophy hunting. Our wildlife deserves better. #BanTrophyHuntingNow"

"Para gadis Dayak, suku terbesar asli Kalimantan, menari mengenakan pakaian adat dan masker untuk meratapi tragedi di tanah leluhur mereka."

Kalo dia bisa ngomong, dia mungkin akan bertanya,"kemana hilangnya satu-satunya rumahku?"

This paper answers why can’t you remember being a baby? For over a century, science said you can't remember being a baby because your infant brain was just too "immature" to record anything. researchers assumed your hard drive was basically turned off for the first two years of life. But this wild paper from Yale completely rewrites how we understand human memory.. Researchers literally put awake babies (between 4 and 25 months old) into an fMRI scanner to watch their brains process new visual experiences in real-time. and what they found is mindblowing.. the infant hippocampus isn't turned off at all. it is actively firing, capturing, and encoding episodic memories. they proved that babies with higher hippocampal activity during a new experience formed a highly stable memory trace. the babies are recording the data. the memory of your first birthday, your first steps, the exact layout of the room you slept in.. it was all successfully saved to your brain. so why can't you remember it? the paper concludes that infantile amnesia isn't an "encoding" problem.. it is a "retrieval" problem. your brain recorded everything perfectly. but as you grew, your brain underwent massive developmental shifts, like explosive neurogenesis (the rapid birth of new neurons), which completely restructured your neural networks. the pathways to access those early files got buried or locked away. you didn't fail to make the memories.. you just lost the encryption key to open them. somewhere deep in your hippocampus, the exact first-person memory of being a 1-year-old might still be sitting there. you just can't access the file anymore.. the human brain is terrifyingly beautiful.

ALL EYES ON OR A NG U T A N. RUMAH MEREKA DI BAK AR. HABI TAT MEREKA DI RAMPASSSSSS OLEH MANUSIA YG HANYA MEMENTINGKAN KEPENTINGAN NYA SENDIRI. OPEN UR EYES. TOLONGGGGGGG.

So few left... We will regret losing them until the end of time.