The NASA Open Science Data Repository (expansion of @NASAGeneLab) has enabled biological & health discoveries helping humanity become multi-planetary by helping life thrive in deep space on Mars and 🌘 OSDR stores precious data anyone can use and analyze, plus a community of collaborative users anyone can join, and several public tools/trainings (including AI/ML) for space biology available 🧵

A new perspective! 🛰️ Voyager 1 had been in space for two weeks and was 7.25 million miles (>11 million km) away OTD in 1977 when it captured this view of the whole Earth and the Moon in the same frame. It was our first image of the kind, but definitely not our last. 1. Voyager 1, 1977 2. DSCOVR, 2015 3. Artemis I, 2022 4. Artemis II, 2026

Dionna and I are excited to come back to San Luis Obispo, where we met 30 years go this month, and join the Mustang community. #CalPolyProud The most meaningful moments of my NASA career were supporting astronauts and their families through missions, and mentoring interns and new hires as they began their own journeys in technical and public service. Service is ultimately about people, all people. I’m excited to share that I have joined my alma mater, @CalPoly, focused on strategic initiatives, partnerships and philanthropy. As I retire from the U.S. Navy and transition to NASA astronaut emeritus, I’m grateful to continue serving NASA while beginning this new chapter at Cal Poly. I look forward to helping create more opportunities for the next generation of STEM, faith, and service leaders through Cal Poly’s Learn by Doing education. NASA Astronaut Victor Glover Returns Full Time to His Alma Mater, Cal Poly, After Historic Artemis II Mission calpoly.edu/news/nasa-astron…

The most meaningful moments of my NASA career did not take place in space. They were supporting astronauts and their families through missions, and mentoring interns and new hires as they began their own journeys in technical and public service. Service is ultimately about people, all people. I’m excited to share that I have joined my alma mater, Cal Poly, focused on strategic initiatives, partnerships and philanthropy. As I retire from the U.S. Navy and transition to NASA astronaut emeritus, I’m grateful to continue serving NASA while beginning this new chapter at Cal Poly. I look forward to helping create more opportunities for the next generation of STEM, faith, and service leaders through Cal Poly’s Learn by Doing education. Dionna and I are excited to come back to San Luis Obispo, where we met 30 years go this month, and join the Mustang community. #CalPolyProud NASA Names Two Artemis II Astronauts to Emeritus Program nasa.gov/news-release/nasa-n… via @NASA

Gonna start a thread of good things that have come out of AI/ML

Explorer friends: HELP! And don’t forget about mental health…

Moderna/Merck just ran a 1,137-patient Phase 3 trial where every single dose was unique to that patient's tumor. It worked. The pipeline: surgical resection → whole exome + RNA sequencing → ML neoantigen ranking → mRNA encoding up to 34 patient-specific targets → manufactured and shipped in 8 weeks. One drug, different sequence for every patient. The ML step is worth to note: the algorithm ingests WES + RNA-seq to identify somatic mutations, then predicts which of those will actually be immunogenic, ie, displayed on tumor cell surface and trigger a T-cell response. It's designed to keep learning from accumulated clinical and immunogenicity data across patients, not just per-patient. INTerpath-001 (Stage IIB-IV resected melanoma, 2:1 randomized): combination with pembrolizumab beat Keytruda alone on both primary (RFS) and key secondary (DMFS) at interim. Phase 2b at ASCO 2026 showed 49% reduction in recurrence/death, 59% in distant metastasis/death at 5 years. Phase 3 confirmed both. What this validates: — tumor-specific neoantigen prediction by ML works in a blinded trial at scale — 8-week personalized mRNA manufacturing is operationally real — effect is additive on PD-1 blockade, not redundant This is first positive Ph3 for individualized neoantigen therapy. First positive Ph3 for any mRNA cancer therapeutic. What a great time to live in!! This is the best time for AI & biotech!

It’s been an absolute privilege teaching Claude how to be a protein designer! By orchestrating open-source protein design and folding models, Claude successfully designed de novo protein binders against 14 of 15 targets, with high success rates and high affinities, as measured by @adaptyvbio and @TwistBioscience. Our results are enabled by multiple landmark innovations in molecular modeling, including, but not limited to: • ESMFold2 and ESMFold2-Fast from @biohub • PXDesign and Protenix v2 from @ByteDanceSeed_ • ipSAE from @RolandDunbrack • RFdiffusion, RFdiffusion3, ProteinMPNN, and SolubleMPNN from @UWproteindesign • FreeBindCraft from @EPFL @AriaxBio • BoltzGen from @boltz_bio • Proteina-Complexa from @NVIDIAHealth • Genie 3 from @ColumbiaSysBio • Caliby and SolubleCaliby from @Stanford • AlphaFold and AlphaProteo from @GoogleDeepMind @IsomorphicLabs

happy to have contributed to this Perspective @CellCellPress. grateful to @califano_lab for leading this effort and to all coauthors

Woh. Very much missed this from June. A brilliant read on the "body gap" in AI and why dual-embodiment may be the true next frontier. Ie, true intelligence isn't more data; it's a the experience of a body (embodiment)

"Snoopy, Baseball, and NASA" is the title of my interview in the latest edition Air & Space Quarterly, the magazine of the Smithsonian National Air and Space Museum. I love the tagline: "A Long Island kid who loved Charlie Brown and the New York Mets would one day repair the Hubble Space Telescope."

THANK YOU FLORIDA 😤

No worries. Expect to see NASA aircraft everywhere. So far this year, Sun ’n Fun, Oshkosh, Washington, D.C., but expect MaxPower, the Houston Airshow, Huntington Beach, and astronaut appearances, like the recent Artemis II tour at various locations. Wouldn’t even be surprised if you see some of NASA’s aircraft flying over football games, other rocket launches, and celebratory events. We need to fly for currency and safety - might as well deliver a bit of inspiration and education along the way.

Just published: "The batch effect that flipped a landmark study". Check it out and subscribe to get everything I'm making. divingintogeneticsandgenomic…

Let’s go, BIG! MAX POWER…

Data data data.... It's priceless.. piped.video/9r2OgiKUzyY @RyanTScott from open science data repository explains here

We return to the Moon to build the base, for the science, the economic potential, and the inspiration, but most importantly, to master the skills we’ll need when we take the next giant leap to Mars.

We’re going big for America’s 250th. 🇺🇸 MAX POWER is coming to Florida Nov. 7-8. @NASA and external collaborators will bring together aviation, aerospace technology, and space exploration for a two-day celebration of American innovation and exploration. This is going to be quite a show. 🚀 Learn more about MAX POWER: nasa.gov/maxpower/

Did you know the human body's systems adapt on different timelines? Neurovestibular issues are immediate, fluid shifts early, while vision problems can appear months later. @RyanTScott @NASAAmes Full episode: piped.video/9r2OgiKUzyY

RT @JerryMoran: Great to welcome Artemis II astronauts @astro_reid and @astro_christina to @the_cosmosphere today with @NASAadmin! Thank yo…

Instead of just watching the next moon mission, get involved! NASA invites everyone to join a global research community, engage with problems, and contribute to science. @RyanTScott @NASAAmes Full episode: piped.video/9r2OgiKUzyY