Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine.
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Auditory stimuli delivered in phase with peaks of #EEG slow waves in the brain increased cerebrospinal fluid (#CSF) flow in healthy adults napping inside an MRI machine, offering insight to treating dysfunctional CSF flow. @MIT_IMES @BostonU_BME scim.ag/4r1JFfe
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The standard immunosuppressant mycophenolic acid has unknowingly been driving the emergence of resistance mutations in the high-priority fungal pathogen #Pjirovecii for almost 2 decades across outbreaks worldwide, shows a new study. @NIH scim.ag/4xpdQ1y
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A “lab-on-a-contact lens” measures concentrations of #serotonin in tear fluid in animals and in humans in a pilot trial—offering a flexible and noninvasive tool to quantify a key marker of stress responses and behaviors. @yangzhi_zhu @TerasakiInstz scim.ag/4yFJYz7
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A “lab-on-a-contact lens” measures concentrations of #serotonin in tear fluid in animals and in humans in a pilot trial—offering a flexible and noninvasive tool to quantify a key marker of stress responses and behaviors. @yangzhi_zhu @TerasakiInstz scim.ag/4yFJYz7
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A CRISPR-based, nanodroplet test can distinguish 15 species of nontuberculous #mycobacteria in clinical samples in just 3.5 hours, avoiding the need for long culture times that have long limited assays for mycobacteria. @Tony_Y_Hu @Qingyun_Liu @Tongji_Uni scim.ag/4AdBbWL
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A nanobody #antivenom cocktail protected mice against death from Indian cobra and king cobra venom, including when delivered up to 20 minutes after envenoming. @LabVenomics @DTUbioengineer scim.ag/4r4WTb5
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The standard immunosuppressant mycophenolic acid has unknowingly been driving the emergence of resistance mutations in the high-priority fungal pathogen #Pjirovecii for almost 2 decades across outbreaks worldwide, shows a new study. @NIH scim.ag/4xpdQ1y
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A “lab-on-a-contact lens” measures concentrations of #serotonin in tear fluid in animals and in humans in a pilot trial—offering a flexible and noninvasive tool to quantify a key marker of stress responses and behaviors. @yangzhi_zhu @TerasakiInstz scim.ag/4yFJYz7
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A "lab-on-a-contact lens" can measure the hormone serotonin in tears to gauge stress levels, researchers trace how an immune-suppressing drug has unexpectedly driven resistance in a fungal pathogen, and more this week in #ScienceTranslationalMedicine. scim.ag/4gS1NF8
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Advanced imaging and genetics identify features of the spleen associated with #coronary artery disease (#CAD) risk, as well as genetic variants associated with these splenic CAD features. @MassGenBrigham @pnatarajanmd scim.ag/4yuQYP6
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A new study shows that intravenous delivery of AAV gene therapy successfully extended survival and reduced symptoms in a feline model of #Sandhoff disease. #TaySachs @auburnvetmed scim.ag/4r7u0Lt
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PET and MRI imaging found elevated levels of TSPO protein in skull bone marrow of people with chronic back pain and knee #osteoarthritis compared with healthy individuals, suggesting a potential new target in treating #ChronicPain @MassGenBrigham
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Auditory stimuli delivered in phase with peaks of #EEG slow waves in the brain increased cerebrospinal fluid (#CSF) flow in healthy adults napping inside an MRI machine, offering insight to treating dysfunctional CSF flow. @MIT_IMES @BostonU_BME scim.ag/4r1JFfe
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A nanobody #antivenom cocktail protected mice against death from Indian cobra and king cobra venom, including when delivered up to 20 minutes after envenoming. @LabVenomics @DTUbioengineer scim.ag/4r4WTb5
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The new issue of #ScienceTranslationalMedicine has arrived!
A recombinant nanobody cocktail protects mice against cobra venom, short bursts of pink noise can boost cerebrospinal fluid flow in sleeping adults, and more. scim.ag/4yvrXUe
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#CRISPR screen reveals that loss of function in ALDH3B2 gene can turn human pancreatic duct cells into beta-like cells that secrete insulin and lower blood glucose levels when transplanted into #diabetic mice @JoslinDiabetes scim.ag/4yoC0dD
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Mouse and human studies show sustained elevated levels of NETs in healing #bone tissue can lead to nonunion, a condition that occurs in up to 15% of fracture patients. scim.ag/4x9jViK
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Researchers studying a #Shigella outbreak at a nonhuman primate research facility identified antibodies that could guide ongoing vaccine development for this deadly diarrheal disease #GHIC @wi_nprc scim.ag/4xxsR2h
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PET and MRI imaging found elevated levels of TSPO protein in skull bone marrow of people with chronic back pain and knee #osteoarthritis compared to healthy individuals, suggesting a potential new target in treating #ChronicPain @MassGenBrigham
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How does #obesity impede weight loss?
New work in mice and human samples reveals that obesity causes disruptions to alternative splicing, efferocytosis, and lipolysis in adipose macrophages—which persist after switching to a low-fat diet. @ShowaUniv_press scim.ag/4gFiWR6
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Applying a minimally invasive microdialysis system, a team captures nuanced patterns in #aldosterone levels over 24 hours in patients with primary #aldosteronism, which could inform timelier diagnostic strategies. @endomedbergen @ederzavala @haukeland_no scim.ag/4zJdsgQ
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By parsing the DNA #fragmentome, a team identifies cell-free DNA signatures that can give early warning during the first trimester of pregnancy complications in women with risk factors such as twinning and autoimmune disease. @CHG_CME @KateEStanley1 scim.ag/3UavEj4
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A new 3D organoid of the human retina faithfully recapitulates the nuanced arrangement of both outer photoreceptors and the RPE layer—and affords new insights into mechanisms and potential targets in retinal degeneration from CLN3 disease. @UofR
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A new analysis decrypts the connection between #UTIs and preterm birth, showing that UTIs trigger strong placental cytokine and immune signatures that correlate with birth outcomes in mice and a pregnancy cohort. @BCMDeptMedicine scim.ag/4campFO
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By parsing the DNA #fragmentome, a team identifies cell-free DNA signatures that can give early warning during the first trimester of pregnancy complications in women with risk factors such as twinning and autoimmune disease. @CHG_CME @KateEStanley1 scim.ag/3UavEj4
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An “off-the-shelf” CAR T cell therapy that targets CD33 has been tested in four patients with relapsed #AML for the first time and is generally well-tolerated, according to new results from a small phase one clinical trial. @UCLchildhealth scim.ag/4wzH0up
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Using a mosaic nanoparticle platform, researchers interrogate how antigen avidity shapes the durability of responses to HIV vaccines in mice and show that high valency elicits more robust B cell and germinal center responses. @UTMB_Pathology scim.ag/4gtOAly
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By analyzing more than 800,000 single-cell profiles in tissues and blood, a team assembles a massive biomolecular compendium of lupus nephritis that maps out its impact on cell populations and could inform future therapeutics. @soumya_boston @BrighamWomens scim.ag/4wDB7MI
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By parsing the DNA #fragmentome, a team identifies cell-free DNA signatures that can give early warning during the first trimester of pregnancy complications in women with risk factors such as twinning and autoimmune disease. @CHG_CME @KateEStanley1 scim.ag/3UavEj4
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The new issue of #ScienceTranslationalMedicine is out now!
The DNA fragmentome can give early warning about pregnancy complications in high-risk patients, a compendium of lupus nephritis reveals how the condition skews cells and tissues, and more. scim.ag/4x6M8HL
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Combining mutant #p53 reactivation via arsenic trioxide with the standard therapy decitabine kills acute myeloid leukemia and MDS cells and shows promise in a small pilot trial in patients carrying rescuable p53 mutations. @sjtu1896 scim.ag/4cnWLgN
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How does antigen avidity impact the durability of the vaccine response?
A team studies HIV vaccination in mice and finds that higher avidity promotes clonal diversity of the B cell response and affinity maturation within germinal centers. @UTMB_Pathology scim.ag/4wZX75F
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A new analysis challenges the conventional wisdom of how #Zika virus particles form by showing that they don’t require full-length premembrane protein for assembly—a finding that could inform new vaccine strategies for flaviviruses. @NIH scim.ag/4wxGI7f
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A phase 1 trial decrypts how fecal microbiome transplants can raise tolerance to peanut antigens by triggering higher amounts of RORγt+ regulatory T cells, sustaining Bacteroides colonization, and increasing bile acid metabolites. @BostonChildrens scim.ag/3SfGmUV
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A team reports on new results from a clinical trial of pneumococcal vaccines to foster immune recovery in adult survivors of #sepsis, showing a lack of clinical benefit but also providing crucial data about variation in vaccine response. @KCLImmunoMicro scim.ag/3SayWlF
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Using a mosaic nanoparticle platform, researchers interrogate how antigen avidity shapes the durability of responses to HIV vaccines in mice and show that high valency elicits more robust B cell and germinal center responses. @UTMB_Pathology scim.ag/4gtOAly
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Research teams decipher the puzzle of how antigen avidity shapes vaccine immunity, a new clinical trial tests whether a pneumococcal vaccine can foster recovery in sepsis survivors, and more this week in #ScienceTranslationalMedicine. scim.ag/4wYCeYw
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Scientists have delineated how abnormal sensory nerve innervation drives the formation of bony bars in injured growth plates via the factor #pleiotrophin—and show that bupivacaine can mitigate bony bars in mice by restraining this nerve sprouting. @JHUPath scim.ag/3RUEj8E
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A switchable, single-atom nanozyme can track down and label individual #glioblastoma cells to inform more precise surgical excision—and also potentiates the tumor-killing effects of phototherapy after surgery in mice. @WeiTaoLab @HenanUniversity scim.ag/4z8UcJq
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A longitudinal analysis of liver transplant recipients reveals a biphasic JAK-STAT signature that distinguishes the likelihood of low-grade organ rejection after transplant, pointing to a potential therapeutic target and monitoring tool. @InstituteStarzl scim.ag/4wbGMtq
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A liposomal nanoparticle therapeutic takes advantage of temporary blood-brain barrier disruption after surgical resection of #glioblastoma tumors to penetrate margins and deliver drugs such as doxorubicin, according to recent preclinical work. @FBMH_UoM scim.ag/4xcrYvA
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A phase 1 trial decrypts how fecal microbiome transplants (#FMT) can raise tolerance to peanut antigens by triggering higher amounts of RORγt+ regulatory T cells, sustaining Bacteroides colonization, and increasing bile acid metabolites. @BostonChildrens scim.ag/3SfGmUV
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The new issue of #ScienceTranslationalMedicine is out now!
A pilot trial reveals how fecal microbiome transplants could attenuate food allergies, scientists uncover time-dependent molecular signatures of organ rejection after liver transplant, and more. scim.ag/4fGkJVC
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A Viewpoint discusses the “safe harbor hypothesis” of how peripheral nerve networks can shield growing tumors, and explores how scientists are aiming to remodel and target this landscape to enhance antitumor immunity. @nicole_scheff @pitt_medicine scim.ag/4wBTmDb
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An emerging body of work takes a holistic, whole-body perspective on #cancers and their place within a person’s neural regulatory network across time, according to the author of a new Viewpoint. @CNI_lab @MIPS_DDB scim.ag/3RLxqq8
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A special issue Viewpoint explores the research landscape and latest discoveries about childhood brain #cancers, including the origins of these tumors and how they integrate with neural networks to fuel their growth. @michelle_monje @Stanford_Neuro scim.ag/4xeUWL7
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In the new issue, scientists dissect the fundamental biological and delivery barriers that have held back therapeutic efforts for #glioblastoma, and consider emerging strategies that could reshape treatments. @EAChiocca @MGBneurosurgery scim.ag/45BQOZN
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A new Review synthesizes the translational pipeline of research decoding how tumors interact with both the central and peripheral nervous systems to fuel their growth—as well as implications for drug repurposing and interventions. @UTMDAnderson scim.ag/4fNuUaW
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In an Editorial, researchers introduce a special issue on cancer #neuroscience, and discuss the broad arc of research discoveries that have illuminated how cancers hijack the nervous system. @matipittarello @NeurosurgUCSF scim.ag/4bUoAx2
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