Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine.
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Auditory stimuli delivered in phase with peaks of #EEG slow waves in the brain increased cerebrospinal fluid (#CSF) flow in healthy adults napping inside an MRI machine, offering insight to treating dysfunctional CSF flow. @MIT_IMES @BostonU_BME scim.ag/4r1JFfe
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The standard immunosuppressant mycophenolic acid has unknowingly been driving the emergence of resistance mutations in the high-priority fungal pathogen #Pjirovecii for almost 2 decades across outbreaks worldwide, shows a new study. @NIH scim.ag/4xpdQ1y
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A “lab-on-a-contact lens” measures concentrations of #serotonin in tear fluid in animals and in humans in a pilot trial—offering a flexible and noninvasive tool to quantify a key marker of stress responses and behaviors. @yangzhi_zhu @TerasakiInstz scim.ag/4yFJYz7
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A “lab-on-a-contact lens” measures concentrations of #serotonin in tear fluid in animals and in humans in a pilot trial—offering a flexible and noninvasive tool to quantify a key marker of stress responses and behaviors. @yangzhi_zhu @TerasakiInstz scim.ag/4yFJYz7
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A CRISPR-based, nanodroplet test can distinguish 15 species of nontuberculous #mycobacteria in clinical samples in just 3.5 hours, avoiding the need for long culture times that have long limited assays for mycobacteria. @Tony_Y_Hu @Qingyun_Liu @Tongji_Uni scim.ag/4AdBbWL
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A nanobody #antivenom cocktail protected mice against death from Indian cobra and king cobra venom, including when delivered up to 20 minutes after envenoming. @LabVenomics @DTUbioengineer scim.ag/4r4WTb5
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The standard immunosuppressant mycophenolic acid has unknowingly been driving the emergence of resistance mutations in the high-priority fungal pathogen #Pjirovecii for almost 2 decades across outbreaks worldwide, shows a new study. @NIH scim.ag/4xpdQ1y
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A “lab-on-a-contact lens” measures concentrations of #serotonin in tear fluid in animals and in humans in a pilot trial—offering a flexible and noninvasive tool to quantify a key marker of stress responses and behaviors. @yangzhi_zhu @TerasakiInstz scim.ag/4yFJYz7
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A "lab-on-a-contact lens" can measure the hormone serotonin in tears to gauge stress levels, researchers trace how an immune-suppressing drug has unexpectedly driven resistance in a fungal pathogen, and more this week in #ScienceTranslationalMedicine. scim.ag/4gS1NF8
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Advanced imaging and genetics identify features of the spleen associated with #coronary artery disease (#CAD) risk, as well as genetic variants associated with these splenic CAD features. @MassGenBrigham @pnatarajanmd scim.ag/4yuQYP6
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PET and MRI imaging found elevated levels of TSPO protein in skull bone marrow of people with chronic back pain and knee #osteoarthritis compared with healthy individuals, suggesting a potential new target in treating #ChronicPain @MassGenBrigham
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Auditory stimuli delivered in phase with peaks of #EEG slow waves in the brain increased cerebrospinal fluid (#CSF) flow in healthy adults napping inside an MRI machine, offering insight to treating dysfunctional CSF flow. @MIT_IMES @BostonU_BME scim.ag/4r1JFfe
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The new issue of #ScienceTranslationalMedicine has arrived!
A recombinant nanobody cocktail protects mice against cobra venom, short bursts of pink noise can boost cerebrospinal fluid flow in sleeping adults, and more. scim.ag/4yvrXUe
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#CRISPR screen reveals that loss of function in ALDH3B2 gene can turn human pancreatic duct cells into beta-like cells that secrete insulin and lower blood glucose levels when transplanted into #diabetic mice @JoslinDiabetes scim.ag/4yoC0dD
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Researchers studying a #Shigella outbreak at a nonhuman primate research facility identified antibodies that could guide ongoing vaccine development for this deadly diarrheal disease #GHIC @wi_nprc scim.ag/4xxsR2h
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PET and MRI imaging found elevated levels of TSPO protein in skull bone marrow of people with chronic back pain and knee #osteoarthritis compared to healthy individuals, suggesting a potential new target in treating #ChronicPain @MassGenBrigham
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How does #obesity impede weight loss?
New work in mice and human samples reveals that obesity causes disruptions to alternative splicing, efferocytosis, and lipolysis in adipose macrophages—which persist after switching to a low-fat diet. @ShowaUniv_press scim.ag/4gFiWR6
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By parsing the DNA #fragmentome, a team identifies cell-free DNA signatures that can give early warning during the first trimester of pregnancy complications in women with risk factors such as twinning and autoimmune disease. @CHG_CME @KateEStanley1 scim.ag/3UavEj4
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