The Shechner lab in UW Pharmacology. We study Noncoding RNAs and cellular architecture. He/His/Him. All comments are my own. @ShechnerLab.bsky.social
Seattle, WA
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We often think of mitochondria as one interconnected network. But are all mitos the same? Our new preprint-a fantastic collaboration with @SancakLab-reveals that organelle contacts establish specialized mitochondrial populations. Check out @YaseSancak’s awesome thread 👇
Excited to share our new preprint!
biorxiv.org/content/10.64898…
We know that mitochondria make contacts with organelles, but determining whether these contacts establish functionally distinct mitochondrial populations has been challenging.
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📄 Our latest review is out in Current Opinion in Chemical Biology!
We discuss a growing class of oligo-directed proximity labeling tools that use programmable DNA hybridization to target RNAs and genomic loci. A fun piece to write with SheqLab folk!
bit.ly/4h6KaRV
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🤩🤩🤩
Polymerase ribozymes every day!!
#RibozymesEveryDay
Finally, 3D #cryoEM structure of a nucleotide polymerizing #RNA that copies #RNA to #RNA: tC19z, evolved at LMB MRC 15 y ago! biorxiv.org/content/10.64898… @Szokoli_Deni Jason Hingey, Dan Haack, Vivian Wu @nickspellmon @navtejtoor @HHMIJanelia
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Massive win for @CellularIntelHQ! Congratulations, @arjunrajlab, on this exciting new chapter!
I am beyond humbled to take on the role of CSO at Cellular Intelligence while on leave from Penn! Thrilled to have the opportunity to work with an incredible team tackling hugely exciting and challenging problems!
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I want to formally thank @RDasLab and the folks at @eternagame for at last—after 26 years—helping to finish my PhD project. 😅 Ribozymes every day! #RibozymesEveryDay
We and @eternagame are joining the quest to find a molecule that can sustainably replicate itself. Pilot results on first 1000 designs are posted, next up will be million-design-scale expts. Come design at eternagame.org/labs/14660266 by Aug 31, 2026! #RNAworld
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Delighted to announce that, as of today, I’ve been officially promoted to Associate Professor (without Tenure) of Pharmacology @UW
I am deeply endebted to my colleagues, mentors, and the talented trainees in my group. Working with you has been the highlight of my career!
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🎨🧁 Celebrate RNA Day 2026 with creativity!
@RNASociety Junior Scientists are excited to announce the 2026 RNA Society Art & Baking Contests, proudly sponsored by @lexogen. Showcase your RNA-inspired visual art or culinary creations for a chance to win cash prizes!
🏆
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There’s nothing *quite* like seeing two of my favorite labs collaborating on truly beautiful work. Congrats to all involved!!
Excited to share our collaborative work with the @TonyMustoe and @SuperSciJew labs, led by the fearless @RitwikaBose15.
In this study, we developed RAID-MAP, an approach to map RNA structure within biomolecular condensates in living cells.
biorxiv.org/content/10.64898…
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Good *gravy*, that’s beautiful! Congrats too all the authors!!
First AI-generated RNA with novel atomically ordered 3D fold! With @eternagame @StanfordBiochem @chaitjo @PossuHuangLab @UWproteindesign @ShujunHe0717 @navtejtoor @HHMIJanelia on bioRxiv doi.org/10.64898/2026.05.21.…
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Today we report single-cell APEX-seq (scAPEX-seq) — a new method for unbiased mapping of *subcellular* transcriptomes at single-cell resolution. This approach reveals cell states that are not detectable by standard scRNA-seq, and enabled us to identify regulators of CAR T function that improve solid tumor killing.
biorxiv.org/cgi/content/shor…
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AWESOME CONFERENCE ALERT!!
I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun!
Talk abstract deadline: 10/17
Details👇
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Nucleoli + AI = NucleolAI?
Seriously, this is awesome work! Congrats to all the authors!
I’m thrilled to share our preprint that uses deep learning to interrogate structure-function relationships in condensates! biorxiv.org/content/10.1101/… In here, we ask: can AI read condensate biology from pictures alone? Turns out yes... see what we discover below! 🤖🧬🖼️ (1/10)
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*Huge* win for @genentech! Congrats, @DNAmyStrom!!
I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology!
I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.
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Amazing work, as always, from @Mayr_Christine’s lab. Congrats to all authors!!
More than 2700 3′UTRs are highly conserved.
These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance.
Highly conserved 3′UTRs help the folding of proteins with long IDRs.
biorxiv.org/content/10.1101/…
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Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @CellReports, @FKHM and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
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