I sat down for a break during my morning walk at #ICE2024Kyoto and this guy started croaking at me. How appropriate.
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Building Better Bugs retweeted
We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. @Kalkreuter @guichun98 @nchembio nature.com/articles/s41589-0…
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AmberBio is hiring: amber.bio/careers. I highly recommend looking into it if you want to work at a fast-moving startup with a creative and impactful technology. @themicrobeguy
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Looking for a postdoc? We are currently hiring plant synthetic biologist to work on an exciting and collaborative DoE project.
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Great work by Tepper, Maselko, et al. Fish that break down methylmercury!
Very excited to share our preprint demonstrating that animals can be engineered to bioremediate methylmercury! Amazing work by @Dr__Tepper biorxiv.org/content/10.1101/…
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Trick or treaters aren't letting me leave the building to go teach.
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Minnesota is dressing up like Christmas for Halloween. I think I have seen this movie.
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Thanks @themicrobeguy for a great seminar on engineered trans-splicing. Great our alumni crushing it @umncbs
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Putting this on the summer reading list. Looks exciting Basem.
🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n) biorxiv.org/content/10.1101/…
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At high ratios of male-to-female, (i.e., ratios that are expected for many mosquito biocontrol approaches), the females are pestered to the point where they no longer blood-feed, improving the performance of the biocontrol in an interesting and unexpected way!
For all those using genetic control based on the release of males… high male to female ratios may block disease transmission quicker than expected… check our preprint with videos…😅 researchsquare.com/article/r…
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Building Better Bugs retweeted
If you cannot explain something in simple terms, you don't understand it.
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We did not set out to develop new #SynBio tools for plants, but when the existing tools weren't cutting it (or more specifically weren't expressing it), postdoc Armando Casas-Mollano decided we needed improved CRISPRa for plants. [1/2]academic.oup.com/nar/article…
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I am proud of the work that Armando, Matt, and Adam published here, but even more excited for the complex systems engineering that these tools are enabling in the lab (more papers to come soon!) [2/2]
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I am proud of Armando's paper, but even more excited about the complex engineered systems that these tools are enabling (more papers to come soon!) [2/2]
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Nature's idea of an April Fools joke
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I especially liked his blog on mouse models [nikomccarty.com/everything-w…]. Making model organisms more predictive of the thing they are supposed to be modeling is a worthwhile goal of near-future Synthetic Biology (Engineering Biology?, what are we saying now?).
I love Niko's writing - I've been an avid reader of his for years and I'm lucky to get to work with him now at @AsimovBio. We have a bunch of cool things in the works, stay tuned!
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See Szu-Yi Campbell (nee Hsu)'s work on applying Design of Experiments to metabolic pathway engineering in Metabolic Engineering. Interesting and unexpected impact on colony morphology (Jihaeng Li) and simulations to extend results (Adam Sychla) authors.elsevier.com/a/1gilT…
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