Co-Founder @ Amber Bio ⌬ PhD from @Doudna_lab & BanfieldLab @UCBerkeley🌋🦠👨💻🧬⌬Science #ForbesUnder30 ⌬ formerly @NASAAmes, 🇪🇬🇺🇸 ⌬ #crispr #phage #borgs
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🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)
biorxiv.org/content/10.1101/…
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A great day for RNA, and for groundbreaking science performed at biotech companies! #NobelPrize
“Ten years ago I was kicked out and forced to retire.”
Our new medicine laureate Katalin Karikó (@kkariko) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges.
Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.
Listen now:
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Thanks @Smanski_Lab for the invite! It was wonderful to share some of our work and hear from faculty and students. Till next time!
Thanks @themicrobeguy for a great seminar on engineered trans-splicing. Great our alumni crushing it @umncbs
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
Thanks @themicrobeguy for a great seminar on engineered trans-splicing. Great our alumni crushing it @umncbs
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
Had a blast interviewing @themicrobeguy at our @SkyDeck_Cal x @a16zBioHealth student mixer last night. From spotting a synthetic biology flyer in undergrad to quickly becoming a trailblazing scientist-entrepreneur in that field -- what a remarkable journey it's been 🚀@UCBerkeley
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Thanks to @JuliaBauman2 for this neat recap of our recent work! Stay tuned for updates 🙂
A potentially high-efficiency alternative to making large genome edits: making large RNA edits via splicing!
Very cool proof-of-concept from @jacobborrajo @Kamyab_J @themicrobeguy & @BlaineyLab in @biorxivpreprint
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
See also thread explaining Splice Editing by Amber Bio co-founder @themicrobeguy:
🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)
biorxiv.org/content/10.1101/…
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
By targeting RNA rather than DNA, Amber Bio aims to treat multiple genetic diseases with fewer safety risks. trib.al/HOxDx7z
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
Newco news: With $26M in funding, RNA editing firm Amber Bio targets diverse mutations bioworld.com/articles/699706… #biotech #pharma
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
Latest CRISPR news -> shorturl.at/fDIS7
🚀Amber Bio launches with an oversubscribed $26M seed financing round, which will be used to develop RNA-editing therapies for previously undruggable diseases. Co-founded by Basem Al-Shayeb, Ph.D. & Jacob Borrajo, & they are #hiring
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We're on a mission to develop intrepid new approaches to RNA medicines. Towards commercialization, we’ve announced the launch of Amber Bio this ~AUG~, with funding from visionary teams at @Playground_VC, @a16z, @EliLillyandCo & more. If this work interests you, we're hiring!
🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)
biorxiv.org/content/10.1101/…
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
Excited to share our recent study describing a new gene editing approach capable of extensive multi-kilobase edits. When DNA is giving you problems look into the RNA. Much more to come, so stay tuned. biorxiv.org/content/10.1101/…
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
CRISPR-Cas and Splicing at kilo base level 🤩🤯👨🏻🔬👩🔬🧬
🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)
biorxiv.org/content/10.1101/…
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
Beautiful work—potentially a game-changer! Congrats to the whole team!
🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)
biorxiv.org/content/10.1101/…
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
Neat, splice swapping for RNA editing
🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)
biorxiv.org/content/10.1101/…
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
This is SO COOL. It's like RNA editing on steroids!
🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)
biorxiv.org/content/10.1101/…
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
Cool work! Cas mediated splicing between transcripts!
🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)
biorxiv.org/content/10.1101/…
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Basem Al-Shayeb, Ph.D. 🧬 retweeted
CRISPR and splicing together at last! Congrats @themicrobeguy !
🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)
biorxiv.org/content/10.1101/…
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🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)
biorxiv.org/content/10.1101/…
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Since RNA is a highly regulated molecule in the cell, the levels of a target RNA would also be under endogenous cellular control, and one could more easily maintain natural transcriptional levels to make the right levels of protein at the right time (12/n)
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