Official Twitter account of the Blainey Lab @broadinstitute
Cambridge, MA
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And in an excellent news piece from @broadinstitute more context on our cellular self-reporting platform published in @CellCellPress broadinstitute.org/news/new-…
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Out now in @CellCellPress our approach for cellular-self reporting: live-cell transcriptomics with engineered virus-like particles in collab w/ @LindaGGriffith1 lab @MIT @broadinstitute cell.com/cell/fulltext/S0092…
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Blainey Lab retweeted
Now online! Live-cell transcriptomics with engineered virus-like particles dlvr.it/TVH0VM
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Now online in @genomebi a genome-wide screen in 8 days with the OttoSeq automated OPS platform, in collaboration with @mat10_d @cheeseman @broadinstitute link.springer.com/article/10…
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Exciting new open science venture from lab alum @beccajcarlson and colleagues
AI has transformed how we design therapeutics.
But targeted delivery is still an expensive guessing game.
Today @BobbyHollings and I are launching @deliverome with @beckypferdehirt and @radialscience at @AsteraInstitute, to fix that. 🧵
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Blainey Lab retweeted
Using an image-based screening method, Broad and Boston University researchers found potential new drug targets for reducing Ebola infection severity, uncovering human genes that, when silenced, impaired Ebola’s ability to replicate. broad.io/Ebola-News-0724
ALT A micrograph showing an Ebola virus particle in yellow on a purple background
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Out now in @NatureMicrobiol @beccajcarlson and our lab collab w/ Rob Davey's lab @neidl on high-content image-based perturbational screening for regulators of Ebola virus infection @broadinstitute nature.com/articles/s41564-0…
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Blainey Lab retweeted
We’re @BlaineyLab sharing a major update to CROPseq-multi, our versatile system for CRISPR screens that is compatible with individual and combinatorial perturbations, diverse SpCas9-based technologies, and multiple high-content, single-cell readouts. biorxiv.org/content/10.1101/…
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Out now in @CellReports our collab w/ @BiedererLab on image-based pooled genetic screening to identify regulators of synapse formation cell.com/cell-reports/fullte…
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Blainey Lab retweeted
Researchers at the @broadinstitute have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of #antibiotics against drug-resistant bacteria.
✏️ Abstract: bit.ly/4kry8lu
📰 Press Release: bit.ly/3T5TSap
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Blainey Lab retweeted
Excited to share my primary PhD work! Vibrio isolates can produce peptide deformylase inhibitors that induce prophages in their lysogenic competitors.
Not only is it SOS-independent, but also serves as the first example linking translational stress with prophage induction 👀 1/
Bacterial peptide deformylase inhibitors induce prophages in competitors biorxiv.org/content/10.1101/… #biorxiv_micrbio
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Recently published in @PNASNews our high-throughput screen of 1.3M+ antibiotic combos identified P2-56 as a rifampin potentiator against A. baumannii & K. pneumoniae. pnas.org/doi/10.1073/pnas.24…
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Excited to share the 1st of several stories dissecting TEs + chromatin in normal/malignant hematopoiesis. We identified histone demethylases KDM4A/C as vulnerabilities in DLBCL + discovered novel KDM4 inhibitors. Preprint👇
@broadinstitute @BostonChildrens
biorxiv.org/content/10.1101/…
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Excited to see the work from @mgentili_ @beccajcarlson and others from our collab with the Hacohen lab @broadinstitute out now!
Our image-based genome-wide screen identifying new regulators of STING localization is now online at @CellSystemsCP!
authors.elsevier.com/c/1kEhc…
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Blainey Lab retweeted
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
biorxiv.org/content/10.1101/…
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Blainey Lab retweeted
In collaboration with @weallen1 and Xiaowei Zhuang, we have developed Perturb-multi: biorxiv.org/content/10.1101/…
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
biorxiv.org/content/10.1101/…
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Available now via @biorxivpreprint is our preprint on live-cell transcriptomics with engineered virus-like particles @broadinstitute biorxiv.org/content/10.1101/…
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Out now in @cellcellpress - our story about metabolic differences in the vaginal microbiome led by @mzhu_ology @broadinstitute in collaboration with the @kwonlab at @ragoninstitute and others: cell.com/cell/fulltext/S0092…
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We're hiring for a postdoc to work with us on the technical development and deployment of optical pooled screening (OPS) technology! Details and apply here: broadinstitute.avature.net/e…
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We're hiring! We are seeking an exceptional postdoc associate to help us work on solving the antibiotic resistance crisis, details and apply here: broadinstitute.avature.net/e…
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