We are interested in the immune infiltrate in Breast cancer and what it means for treatment and prevention.
All over the world
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We've recently launched a global survey on the potential use of #TILs for future trial designs and use in daily practice. We would love to hear what you have to say 👇fd7.formdesk.com/BQA/TILs_TN…
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TILs Working Group retweeted
Red alert 🚨
👏👏🎉🎈New how to score #breastcancer #TIL PHONE APP
Download here ⬇️
apps.apple.com/us/app/bctils…
@TILsWorkGroup
Thank you to @BCRFcure
@OncoAlert
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And with a podcast
open.spotify.com/episode/3oc…
🆕Our Sept issue is now live!
📊Articles: #hepatocellularcarcinoma #NSCLC #rectalcancer #breastcancer #prostatecancer
📉Featuring trials: EMERALD-3, HARMONi, ALINA, STAR-TREC, & GETUG AFU 18
🎨Cover: breast cancer, TILs, and AI
🖱️Read here: thelancet.com/issue/S1470-20…
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TILs Working Group retweeted
Im proud of collaborating with this amazing team ⤵️
Tumour-infiltrating lymphocytes and breast radiotherapy: perspectives ... sciencedirect.com/science/ar…
@TILsWorkGroup @TIL_Working @OncoAlert
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TILs Working Group retweeted
Fresh off the press, our monumental @TheLancetOncol review of the role of stromal tumor-infiltrating lymphocytes in #breastcancer #radiotherapy. Proud and grateful to be part of this work from @TILsWorkGroup.
authors.elsevier.com/c/1nfqT…
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TILs Working Group retweeted
🆕Our Sept issue is now live!
📊Articles: #hepatocellularcarcinoma #NSCLC #rectalcancer #breastcancer #prostatecancer
📉Featuring trials: EMERALD-3, HARMONi, ALINA, STAR-TREC, & GETUG AFU 18
🎨Cover: breast cancer, TILs, and AI
🖱️Read here: thelancet.com/issue/S1470-20…
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TILs Working Group retweeted
Such a privilege to be part of the international TIL Working Group @TILsWorkGroup and to collaborate with Dr. Salgado on NeoTIL. #SABCS @muschollings @stolaney1 @OncBrothers @LoiSher
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TILs Working Group retweeted
Amazing presentation by Roberto Salgado from @TILsWorkGroup
TIL assessment of APHINITY using CASE45 AI model and manual TILs (great ICC)
Combining AI and manual assessment is a better prognostic biomarker than either one of them
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TILs Working Group retweeted
TILs matter in HER2+ BC!
In ShortHER trial, mapping their spatial organization with AI assessing:
🔹Immune-tumor interaction
🔹Aggregates/TLS (Hotspots)
further refines prognosis beyond manual evaluation
PS2-08-11 at #Sabcs25 @UniPadova @iov_irccs @TILsWorkGroup
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TILs Working Group retweeted
Tagging @TILsWorkGroup to amplify this great work
✨✨hot off the press from the #loilab. We show here that pregnancy & breastfeeding is associated with increased T cells in the normal breast and protection against #tnbc #breastcancer moving the role of immunity from treatment to prevention.
👏👏Thanks to @FAndreMD @DrChoueiri @MyriamChalabi for the opportunity to present #ESMO25 @OncoAlert @myESMO
@PeterMacRes @PeterMacCC @UniMelb
thanks to our funders @BCRFcure @TheMarkFdn @NBCFAus
@Nature Article is here: nature.com/articles/s41586-0…
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TILs Working Group retweeted
✨✨hot off the press from the #loilab. We show here that pregnancy & breastfeeding is associated with increased T cells in the normal breast and protection against #tnbc #breastcancer moving the role of immunity from treatment to prevention.
👏👏Thanks to @FAndreMD @DrChoueiri @MyriamChalabi for the opportunity to present #ESMO25 @OncoAlert @myESMO
@PeterMacRes @PeterMacCC @UniMelb
thanks to our funders @BCRFcure @TheMarkFdn @NBCFAus
@Nature Article is here: nature.com/articles/s41586-0…
Translational data shows that #breastfeeding helps personal immunity improving CD8+ T
This work can help to understand better the immune system and breastfeeding mechanisms @LoiSher @OncoAlert #ESMO25 @FernandoOnco
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The EU-funded MSCA Doctoral Network “Spatial Crosstalk in Immune-Oncology” (SpaXio) is now officially recruiting 14 PhD students to decipher the metastasis-promoting microenvironment of colon and breast cancer. More info here: tilsinbreastcancer.org/wp-co…
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TILs Working Group retweeted
😎if #TIL had been the prespecified biomarker, pembrolizumab might well be approved for this indication. PD-L1 IHC has real technical limitations- patients deserve multiple validated ways to identified immune enriched tumors. #TILs are simple, free & readily available- wait 🤔is that the problem? @oncoalert @TILsWorkGroup #bcsm
💫🌟Association of potential biomarkers with clinical outcomes in metastatic TNBC treated with pembrolizumab or chemotherapy
👉 nature.com/articles/s41523-0…
@JavierCortesMD @ProfAnthoG @ASCOPres @Prof_Nadia_H @LoiSher
🧬 KEYNOTE-119 exploratory biomarker analysis
🔹 TILs ≥5% → ↑ ORR, PFS, OS with pembrolizumab (not chemo)
🔹 T-cell–inflamed GEP → predictive of better ORR, PFS, OS
🔹 TMB ≥10 mut/Mb → trend toward longer OS
🔹 BRCA/HRD → no predictive association
🔹 TILs + GEP show independent predictive value → immune-inflamed tumors benefit most
🧠 Clinical insight: Immune-active biomarkers (TILs, TcellinfGEP, TMB) identify TNBC subsets deriving durable benefit from pembrolizumab.
@myESMO @OncoAlert @ASCO @NatureCancer @BreastCancerRes
#TNBC #BreastCancer #Immunotherapy #KEYNOTE119 #PDL1 #Biomarkers #OncoTwitter
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Study across 45 institutions shows AI validity in TIL quantification for melanoma. Reproducible with prognostic validity and open-source. @tznaung 👉 jamanetwork.com/journals/jam…
#AIinPathology #Melanoma #ComputationalPathology
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TILs Working Group retweeted
Some studies shows how we can reduce costs based on biomarkers
SHORT-HER 9 weeks of trastuzumab is ✅ based TILS 20% or more
@TILsWorkGroup @OncoAlert #oncoalertAF @JAMAOnc⤵️
jamanetwork.com/journals/jam…
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🎉 Thrilled to share that 2 @JPathol papers from the TILs Working Group ranked in the Top 10% most-viewed in 2023!
👏 Huge thanks to all collaborators, @JPathol & our readers for your support.
📎 Links in comments ⬇️
#TopViewedArticle #TILsinBreastCancer #pathology
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📄 Pitfalls in ML-based TIL assessment
🔗 doi.org/10.1002/path.6155
📄 Spatial analyses of immune infiltration in cancer
🔗 doi.org/10.1002/path.6165
#ImmunoOncology #DigitalPathology #TILs
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TILs Working Group retweeted
Great slide highlighting not only are TILs predictive of pCR...it also translates to being prognostic beyond pCR for good outcome and DFS.
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@SABCSSanAntonio
@OncoAlert
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