Professor and scientist fascinated by infectious diseases, host-microbe interactions and bacterial infections. Views my own 🇵🇷 #CienciaBoricua#MacFellow
Clostridioides difficile couples responses to host nutritional immunity and a commensal-derived antibiotic to enable growth in the gut | Science Signaling science.org/doi/10.1126/scis…
Applications are now open for the St. Jude Graduate School of Biomedical Sciences! Become part of the next generation of leaders in biomedical research, global health, clinical investigation and data science.
Apply today: gradschool.stjude.org/
TCR specificity prediction is advancing rapidly. The central question is not only which TCR sequence recognizes an antigen, but also which TCR pairings make recognition possible & where is the binding boundary? Our new paper tackles this question. 🧵
science.org/doi/10.1126/scie…
Researchers from St. Jude and collaborating institutions developed AdaptiveFlow, an AI-informed platform, that can virtually screen 69 billion drug-like molecules with a 1,000-fold reduction in computational costs. By expanding access to ultra-large virtual screening, the open-source platform could help accelerate therapeutic discovery. bit.ly/4zQuERq
PhIX-MS is out in Molecular Cell! We use rapid in situ photo-crosslinking to trap transient proteasome interactions, then combine crosslinking MS, cryo-EM and AlphaFold to define how they bind.
Paper: doi.org/10.1016/j.molcel.202…
Preview: doi.org/10.1016/j.molcel.202…
Now open - LOIs for the Investigators in the Pathogenesis of Infectious Disease (PATH) program. Deadline is July 16 @ 3pm ET.
Faculty in US and Canada are eligible to apply
Grant Amount: $505,000 over five years
More information here: buff.ly/mBR4XST#bwfpath
ALT The Burroughs Wellcome Fund is pleased to announce the recipients of the 2026 Investigators in the Pathogenesis of Infectious Disease (PATH) awards, recognizing assistant professor-level scientists whose research is advancing understanding of infectious disease mechanisms and informing new approaches to prevention, diagnosis, and treatment.
Delighted to see our work recently published in @NatureComms!
In our article we describe a small RNA with a unique modular structure that shapes the evolution of the cholera pathogen
nature.com/articles/s41467-0…
Findings show a small RNA in the cholera bacterium influencing Vibrio cholerae colonization of the gut. Human-associated variants regulate 85% of genes tied to virulence and intestinal colonization, supporting the need for improved outbreak surveillance. ow.ly/cF2A50YZG6Q
More than thrilled to share that I’ve been promoted to full (tenured) Professor @harvardmed@Harvard. This only happened because of the hard work of many people, but I want to dedicate this promotion to my grandmas, Nonna Maria & Nonna Vevè. A #FirstGen thread 🧵 1/x
Does an imbalanced gut microbiome worsen chronic kidney disease?
By elucidating the ecological causes for changes in the gut microbiota composition and its consequences for disease progression we were able to answer this question.
Read more at: pubmed.ncbi.nlm.nih.gov/4185…
📷Jose Lemos 🇧🇷📷@josealemos
A reminder that abstract submission and applications for the Streptococcal GRC/GRS are open, and the meeting is on track to fill quickly. If interested in presenting, note that early registration is important for consideration for short-talk slots.
Beyond thrilled to finally see my postdoctoral work with @Horswill_Lab published in @NatureComms. Here we report how the absence of the surface associated collagen binding adhesin causes visibly worsened skin infection. Bacterial deception at its best!
nature.com/articles/s41467-0…
Excited to announce the upcoming 2026 Microbial Toxins and Pathogenicity GRC and GRS meeting taking place July 12 - 17, 2026 at Waterville Valley in New Hampshire. This meeting will be chaired by yours truly and co-chaired by @SunnyShinLabgrc.org/microbial-toxins-and…
Excited to share our study resolving the GTP-induced activation of the mu-opioid receptor-Gi complex with different agonists using cryoEM and MD simulations is live now @Nature, with additional MD sims, fluorescence work, and more! nature.com/articles/s41586-0…
Researchers have revealed a hidden intermediate state at the center of Src kinase function. This fleeting state is vital for rapid cell migration and T-cell activation, opening new possibilities for targeting kinases. ow.ly/HWe450XLHbg
Innate Immune Memory Meeting 2026 |Sep 23-25| Montreal, Canada. Registration and abstract submission are now open. Join us in Montreal for cutting-edge science on innate immune memory, from evolution to vaccines. Register today!
event.fourwaves.com/ti2026me…