A structural bio lab using electron microscopes to study HIV, Ebola, Flu, Malaria, Coronaviruses, and membrane proteins. Views are our own.
San Diego
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The Ward Lab retweeted
Congratulations to new @NSF #GRFP fellows: Gabrielle in the @MGClab, Jared in the lab of Luke Lairson, @alexxsaladbar in the @LanderLab, Leigh in the @WardLab1 and Noah in the @disney_lab!
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The Ward Lab retweeted
Holding it together: Nanoparticle stabilization of LASV trimer. @bmgunn31 examines work of @AA_Lab_EPFL @WardLab1 using two-component nanoparticle strategy that enables stable trimeric presentation of #Lassavirus glycoprotein complex & induction of bnAbs cell.com/cell-host-microbe/f…
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The Ward Lab retweeted
Featured Article: Lassa GPC nanoparticles- path to a vaccine? Stabilized #Lassa virus glycoprotein nanoparticle vaccine induces potent #antibody responses in rabbits & protects guinea pigs from #Lassavirus challenge @WardLab1 @AA_Lab_EPFL Brouwer & Sanders cell.com/cell-host-microbe/f…
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Incredible work from Philip, @AA_Lab_EPFL, Rogier Sanders (@amsterdamumc) and more! Officially out in @cellhostmicrobe. We describe the presentation of Lassa GPC on nanoparticles and show it can induce neutralizing responses at a novel epitope. Full story: cell.com/cell-host-microbe/f…
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The Ward Lab retweeted
New in Science: Researchers have determined the cryo–electron microscopy structure of the hepatitis C virus E1E2 glycoprotein complex.
The structure provides a blueprint for the design of vaccines and drugs that target the virus. scim.ag/jP
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The Ward Lab retweeted
A new endowed fund set up by Prof. Andrew Ward is helping up-and-coming scientists from under-represented backgrounds to enroll in university without the worries of financial insecurity. Congratulations to inaugural recipient Alesandra Rodriguez magazine.scripps.edu/profile… @WardLab1
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Another malaria CSP antibody story describing the structural basis of how unique homotypic interactions in the L9 antibody result in a potent and protective phenotype! #malaria #cryoEM. Now available in BioRxiv biorxiv.org/content/10.1101/…
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The Ward Lab retweeted
Two studies from Prof. Bill Schief’s lab & collaborators describe an approach to design a custom HIV vaccine that can coax the immune system to produce the right broadly neutralizing antibodies in a stepwise manner scripps.edu/news-and-events/… @ImmunityCP @ragoninstitute @moderna_tx
ALT structural image of an antibody
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The Ward Lab retweeted
And here's a short video what we're doing for a universal, variant-proof Covid vaccine, via joint efforts of immunology and structural biology, with @DennisRBurton and Ian Wilson, @WardLab1
piped.video/watch?v=O2d8jG7b…
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Great talk from Julianne and work from Team Flu!
Beautiful analysis of maturation and cross-reactivity of antibody responses following flu vaccination by @julianna_han @OptionsXi @WardLab1 Specificity lost to cross-reactivity and mapping of how HA escapes. Bonus points for having to work with @TheBcellArtist (my sympathies)
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Outstanding work from @HaileePerrett and Philip Brouwer, go check out the paper and the beautiful Lassa GPC figures. Congrats to all involved!
Really excited to finally share our work on #Lassa's fusion glycoprotein (GPC) on bioRxiv!
We explore GPC structures across lineages, antibodies targeting the apex of the trimer (which impede receptor binding), and describe a new NAb!
Read more here!🔬
biorxiv.org/content/10.1101/…
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Beautiful work done by our Post Doc Gregory Martin and team including Jon Torres, Grace Gibson, Wilma Lee, Jeffrey Copps. 😍 #thatcryotho #malaria #cryoEM
Very cool #cryoEM reconstructions from @WardLab1! These #malaria Fabs are so cute ☺️
“Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection” | #bioRxiv biorxiv.org/content/10.1101/…
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The Ward Lab retweeted
Many scientists are working toward the gold standard of infectious disease prevention: universal vaccines.
But what does that mean? A quick intro!
(& as always, a huge shoutout to Matt, Faith, and Drew—teamwork makes the dream work!) @scrippsresearch
piped.video/watch?v=1ROgFuDo…
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Keep an eye out for cool science coming from the Murin lab!
Please welcome the Murin Lab @scrippsresearch! We are grateful to currently be housed by @WardLab1 and collaborating with them.
From left to right: @daniel_murin (PI), Kayla Xu (summer intern) and Ryan Lin (Technician).
Our website will be up soon! murinlab.com
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So proud of you @HaileePerrett! Keep up the great work. We are lucky to have you.
Kicking off the start of year 4 of grad school with the official NoA for my NIAID F31. 🎉
Feeling deeply grateful for the support of so many lovely scientists, funding agencies, and donors over the years. The adventure continues!
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Including lots of work from our lab members Wilma Lee and Jon Torres. nsEM getting the job done!
The @andrabi_raiees, @DennisRBurton, and Wilson labs find macaques produce broadly neutralizing, variant-protective antibodies after #SARSCoV2 vaccination – providing insights to guide the design and testing of future #COVID19 vaccines. @scrippsresearch fcld.ly/val5q0x
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The Ward Lab retweeted
Many months & edits later, our work on the baseline SARS-CoV-2 spike-reactive B cell repertoire is (finally!) out in @NatureComms.
⬇ Most interesting & relevant results below. It gets cool. ⬇
@vanGilsLab
nature.com/articles/s41467-0… (1)
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The Ward Lab retweeted
With the help of the very talented @julianna_han @WardLab1, we found out that this IGHV1-69/IGKV3-11 B cell pairing exclusively targets an apical S2 domain, which is normally obscured on the prefusion spike trimer but might be present in open and/or aberrant conformations. (8)
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