AI-Driven Oncology | Cell Therapy | Translational Science | Dir @MedNewsWeek | @OncLive Correspondent | Host, Translational Edge | COI: bit.ly/4uWkjka

New York, NY
Honored and grateful to be invited to speak at this outstanding forum hosted by Memorial Sloan Kettering Cancer Center 🌍✨ I’m excited to share two oral presentations exploring how global oncology, AI, and evidence-based innovation can be translated into real-world action to reduce inequities in cancer care worldwide 📊🧬🤝 Immense gratitude to my mentors, Dr. Bonilla & Dr. Park, and collaborators whose guidance, support, and trust continue to shape this work — none of this is possible without you 🙏💙 Looking forward to engaging conversations, learning alongside leaders across disciplines, and advancing our shared mission to improve cancer care for patients everywhere 🌎🔬 @DrArturoAI @CParkMD
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We have a cure definition for myeloma. Requires: 1) Off all therapy and sustained MRD negative for 5 years 2) Negative imaging studies Presented by @NikhilMunshiMD #IMS26 @Myeloma_Society Note: 1) We need to see how this definition performs. Relapse rate for patients meeting these cure criteria must ideally be less than 5%. If not, we may have to adjust the criteria. 2) I hope the cure criteria will be the impetus to stop doing trials with endless therapy. You cannot claim cure with continuous therapy. I’m glad the field is mostly aligned on this. Cure for patients and public in any disease has a deep meaning. Cure means cure. We cannot dilute it.
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Keynote Speaker Spotlight | ICTO 2026 We are delighted to welcome @YLeyfman, NYP- Meyer Cancer Center, United States, as a distinguished Keynote Speaker at the @cancerconfer, organized by @magnus_group October 8–10, 2026 |Tokyo, Japan 🔗: magnusconferences.com/cancer…
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It was a tremendous honor to host Dr. Kami Maddocks and Dr. Peter Martin, two global leaders who have helped shape the field of lymphoma. We are incredibly grateful for the opportunity to learn directly from their expertise and perspectives on where mantle cell lymphoma care is heading. This is what MedNews Week is all about—bringing together extraordinary leaders, creating meaningful scientific dialogue, and making those conversations accessible to a global community. Thank you again, Dr. Maddocks and Dr. Martin, for your time, your insights, and all that you continue to do for our field and our patients. We can’t wait to share the full episode with the MedNews Week global audience soon! 🎙️🌎 #MedNewsWeek #MantleCellLymphoma #Lymphoma #Hematology #Oncology #CART @kmaddmd @OhioStateMedOnc @OhioStatePIIO @OSUhemoncfellow @NYULH_DeptofMed @Perlmutter_CC @nyulangone @nyugrossman @Pelotonia @MedNewsWeek
Honoured to host Dr @kmaddmd & Dr Peter Martin for the @MedNewsWeek Spotlight – Clinical Exchange. A conversation on where #MantleCellLymphoma practice is heading, from BTKi & MRD to CAR-T, bispecifics and treatment sequencing. @OSUCCC_James @nyulangone
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Thank you to Technology Networks for the invitation and opportunity to present our work on AI-Enabled Standardization for Scalable Cell & Gene Therapy Trial Matching. It was a privilege to represent our incredible team, share our work at the intersection of AI, clinical trial innovation, and cell & gene therapy, and engage in a thoughtful scientific discussion around how these tools can help expand access and bring transformative therapies closer to the patients who need them. Grateful to everyone who joined the conversation and to the Technology Networks team for creating a platform for meaningful scientific exchange. Looking forward to continuing the dialogue and hopefully working together again soon! #ArtificialIntelligence #CellTherapy #GeneTherapy #ClinicalTrials #Oncology #Innovation @Tech_Networks
The future of cell & gene therapy won’t be defined by innovation alone—it will be defined by who can actually access it. Thrilled to be joining Technology Networks as a Featured Speaker on September 24 for a conversation at the intersection of two fields rapidly reshaping medicine: AI and cell & gene therapy. My presentation, “AI-Enabled Standardization for Scalable Cell & Gene Therapy Trial Matching,” will explore a challenge I believe we urgently need to solve: How do we take extraordinary scientific innovation and make sure the right patient can actually find—and reach—the right clinical trial? The next frontier of AI in medicine isn’t simply generating better answers. It’s building tools that can break down barriers, standardize complex decision-making, expand access to clinical trials, and help move transformative therapies from possibility to patients. That is the future I’m incredibly excited to help build. I’m deeply grateful to Dr. Arturo Bonilla for his outstanding mentorship, guidance, and belief in this work, and to Dr. Chandler Park for his continued mentorship and support. Having mentors who challenge you to think bigger—and then help you turn those ideas into something meaningful—is invaluable. And a huge thank you to Technology Networks for providing a global platform to have this conversation. 📅 September 24, 2026 11:00 AM ET Free Registration: technologynetworks.com/tn/we… If you work in AI, oncology, clinical trials, cell & gene therapy, or health equity—or simply want to see where these worlds are converging—I hope you’ll join me. The science is moving fast. Our ability to connect patients to it needs to move even faster. #ArtificialIntelligence #CellTherapy #GeneTherapy #ClinicalTrials #Oncology #PrecisionMedicine #AIinHealthcare #HealthEquity #ClinicalResearch
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Yan Leyfman, MD retweeted
Honoured to host Dr @kmaddmd & Dr Peter Martin for the @MedNewsWeek Spotlight – Clinical Exchange. A conversation on where #MantleCellLymphoma practice is heading, from BTKi & MRD to CAR-T, bispecifics and treatment sequencing. @OSUCCC_James @nyulangone
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What if the next advance in BCMA CAR-T isn’t simply stronger T-cell activation—but more precisely controlled activation? Anitocabtagene autoleucel (anito-cel) uses a synthetic d-domain BCMA binder (ddBCMA) and is being developed for heavily pretreated relapsed/refractory multiple myeloma. In this phase 1 study, 38 patients received anito-cel after ≥3 prior lines of therapy or with triple-class refractory disease. The clinical results were striking: 🔹 100% overall response rate 🔹 79% complete response rate 🔹 24-month PFS: 57% 🔹 Median PFS: 30.2 months 🔹 36-month OS: 65% But the mechanistic story may be even more interesting. At the recommended phase 2 dose, 94% developed grade 1–2 CRS, with no grade ≥3 CRS. ICANS occurred in 16%, predominantly grade 1–2, with one grade 3 event. Investigators compared the ddBCMA binder with a dual-VHH binder corresponding to the published ciltacabtagene autoleucel sequence. Despite similar cytotoxicity, the ddBCMA CAR-T cells demonstrated less cytokine release, without antigen-independent activation or off-target cytotoxicity. The binder also showed a faster off-rate—raising an intriguing possibility that the kinetics of antigen engagement may influence how CAR-T cells balance activation, effector function, and toxicity. That leads to a broader question in CAR-T engineering: Is the goal simply to maximize CAR signaling—or to engineer the right signaling dynamics? As BCMA CAR-T moves into earlier lines of myeloma therapy, optimizing the quality of T-cell activation may become just as important as maximizing its magnitude. The next generation of CAR-T may be defined not only by what the cell targets, but how the receptor engages its target. nejm.org/doi/full/10.1056/NE… #MultipleMyeloma #CART #BCMA #CellTherapy #Immunotherapy #CancerResearch #TranslationalMedicine
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Zara is one of the most promising mentees I have had the privilege of working with through #USMIRC @USMIRCNEWS. She has tremendous potential—not only to become an outstanding resident, but also an exceptional future oncologist. Medicine needs more people like @zarabaloc I am incredibly proud of her and grateful to @YLeyfman for providing such wonderful mentorship and guidance.
Hi #MedTwitter! 👋 I’m Zara Baloch, MBBS, an ECFMG-certified IMG based in Florida, applying to #InternalMedicine for #Match2027. 🔬 Passionate about research, Heme/Onc, medical education & patient advocacy 🎙️ Director of Research & Medical Correspondent at MedNews Week 🎧 Creator & Co-host of Match Confidential Fun fact: A year ago, I never imagined I’d be hosting conferences or interviewing physicians and researchers. Through MedNews Week, I unexpectedly grew to love it, especially the opportunity to learn firsthand from leaders shaping the field. Outside medicine, curiosity describes me best. I love art, museums, nature, ancient civilizations & documentaries (almost always over fiction!). I’m happiest exploring something I haven’t seen or learned about before, from trying freediving to spending hours in a museum. And no matter what city I’m in, I somehow always find a pickleball court. 🏓 I’m also drawn to Stoic philosophy, particularly Marcus Aurelius, and enjoy incorporating lessons from The Daily Stoic into everyday life. “The impediment to action advances action. What stands in the way becomes the way.” -Marcus Aurelius Looking forward to connecting with applicants, residents, faculty & mentors this Match season! AAMC ID: 16315579 @MedNewsWeek @ProjectImg #IMG #ERAS #ECFMG #MedEd #HematologyOncology #match2027 #ERAS2027
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Every so often, you have the privilege of working with someone whose impact is difficult to capture in a CV. Dr. Zara Baloch is one of those people. Over the time I’ve had the privilege of working with Zara at MedNews Week, I’ve watched her grow into an exceptional leader, scholar, communicator, and teammate. She brings a rare combination of intellectual curiosity, meticulous attention to detail, humility, warmth, and an extraordinary ability to adapt and grow. But what distinguishes Zara most is the effect she has on the people around her. She is the person who notices what others miss, steps forward when something needs to be done, brings people together, and quietly raises the standard for everyone on the team. She leads without needing the spotlight and approaches every opportunity with genuine curiosity and a desire to become better. In many ways, she has become one of those invaluable “glue people” every successful team and institution needs—and very few are fortunate enough to find. I have seen Zara take on increasingly complex responsibilities in research, medical education, interviewing physicians and scientists, and organizational leadership, and with each new challenge she has continued to evolve. What has remained constant is her character: thoughtful, dependable, kind, deeply committed to others, and relentlessly willing to learn. As she enters the #Match2027 cycle in Internal Medicine, I could not be more excited to see where her journey takes her. I have every confidence that she will bring the same scholarship, humanity, leadership, and collaborative spirit to residency that she has brought to our organization. Internal Medicine programs: take note of Dr. Zara Baloch. Any institution fortunate enough to train her will be gaining not only a talented future physician, but the kind of colleague who makes the people and the institution around her better. Proud of how far you’ve come, Zara—and even more excited for everything ahead. #InternalMedicine #Match2027 #MedTwitter #MedEd #IMG #ERAS2027 #MedicalEducation #Leadership #HematologyOncology @MedNewsWeek @ProjectImg @ProjectImg @zarabaloc
Hi #MedTwitter! 👋 I’m Zara Baloch, MBBS, an ECFMG-certified IMG based in Florida, applying to #InternalMedicine for #Match2027. 🔬 Passionate about research, Heme/Onc, medical education & patient advocacy 🎙️ Director of Research & Medical Correspondent at MedNews Week 🎧 Creator & Co-host of Match Confidential Fun fact: A year ago, I never imagined I’d be hosting conferences or interviewing physicians and researchers. Through MedNews Week, I unexpectedly grew to love it, especially the opportunity to learn firsthand from leaders shaping the field. Outside medicine, curiosity describes me best. I love art, museums, nature, ancient civilizations & documentaries (almost always over fiction!). I’m happiest exploring something I haven’t seen or learned about before, from trying freediving to spending hours in a museum. And no matter what city I’m in, I somehow always find a pickleball court. 🏓 I’m also drawn to Stoic philosophy, particularly Marcus Aurelius, and enjoy incorporating lessons from The Daily Stoic into everyday life. “The impediment to action advances action. What stands in the way becomes the way.” -Marcus Aurelius Looking forward to connecting with applicants, residents, faculty & mentors this Match season! AAMC ID: 16315579 @MedNewsWeek @ProjectImg #IMG #ERAS #ECFMG #MedEd #HematologyOncology #match2027 #ERAS2027
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CML care is rapidly advancing. 🎙️ In this @MedNewsWeek × @oncodaily episode, Jorge Cortes, MD, discusses modern treatment strategies, TKIs, molecular monitoring, treatment resistance and the role of AI in personalized care. Watch the full keynote: piped.video/dtWA2bQ2nX4?is…
What does the future of CML treatment look like? 🎙️ In this MedNews Week Keynote, Jorge Cortes MD(@jorgecortesmd) joins us for an expert discussion on: The CML Evolution: Mastering Modern Algorithms in Chronic Myeloid Leukemia Dr. Cortes takes us through the changing CML treatment landscape, the decisions clinicians face in practice, and where the field is heading next. With decades of experience in leukemia research, leadership in CML clinical trials, and more than 1,000 scientific publications, his perspective brings together both the history and future of CML care. Whether you’re in hematology/oncology, research, or training, this is a keynote worth watching. 🎥 Watch the full keynote: piped.video/dtWA2bQ2nX4?is=yjW8… A special thank you to Dr. Chandler Park (@CParkMD) and Dr. Yan Leyfman (@YLeyfman) for building a platform that brings experts, clinicians, researchers, and trainees together to share knowledge across the medical community. And thank you to Dr. Cortes for sharing his time and expertise with us. #MedNewsWeek #CML #Hematology #Leukemia #Oncology
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Yan Leyfman, MD retweeted
Replying to @DrKrinaPatel
@DrKrinaPatel shining at #IMS26 in making a case for CART at first relaps. 1. Outcomes are better when CART is done earlier 2. Better Tumor Microenvironment and T cell Health 3. treatment free time, one and done approach #mmsm
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Every so often, you have the privilege of working with someone whose impact is difficult to capture in a CV. Dr. Zara Baloch is one of those people. Over the time I’ve had the privilege of working with Zara at MedNews Week, I’ve watched her grow into an exceptional leader, scholar, communicator, and teammate. She brings a rare combination of intellectual curiosity, meticulous attention to detail, humility, warmth, and an extraordinary ability to adapt and grow. But what distinguishes Zara most is the effect she has on the people around her. She is the person who notices what others miss, steps forward when something needs to be done, brings people together, and quietly raises the standard for everyone on the team. She leads without needing the spotlight and approaches every opportunity with genuine curiosity and a desire to become better. In many ways, she has become one of those invaluable “glue people” every successful team and institution needs—and very few are fortunate enough to find. I have seen Zara take on increasingly complex responsibilities in research, medical education, interviewing physicians and scientists, and organizational leadership, and with each new challenge she has continued to evolve. What has remained constant is her character: thoughtful, dependable, kind, deeply committed to others, and relentlessly willing to learn. As she enters the #Match2027 cycle in Internal Medicine, I could not be more excited to see where her journey takes her. I have every confidence that she will bring the same scholarship, humanity, leadership, and collaborative spirit to residency that she has brought to our organization. Internal Medicine programs: take note of Dr. Zara Baloch. Any institution fortunate enough to train her will be gaining not only a talented future physician, but the kind of colleague who makes the people and the institution around her better. Proud of how far you’ve come, Zara—and even more excited for everything ahead. #InternalMedicine #Match2027 #MedTwitter #MedEd #IMG #ERAS2027 #MedicalEducation #Leadership #HematologyOncology @MedNewsWeek @ProjectImg @ProjectImg @zarabaloc
Hi #MedTwitter! 👋 I’m Zara Baloch, MBBS, an ECFMG-certified IMG based in Florida, applying to #InternalMedicine for #Match2027. 🔬 Passionate about research, Heme/Onc, medical education & patient advocacy 🎙️ Director of Research & Medical Correspondent at MedNews Week 🎧 Creator & Co-host of Match Confidential Fun fact: A year ago, I never imagined I’d be hosting conferences or interviewing physicians and researchers. Through MedNews Week, I unexpectedly grew to love it, especially the opportunity to learn firsthand from leaders shaping the field. Outside medicine, curiosity describes me best. I love art, museums, nature, ancient civilizations & documentaries (almost always over fiction!). I’m happiest exploring something I haven’t seen or learned about before, from trying freediving to spending hours in a museum. And no matter what city I’m in, I somehow always find a pickleball court. 🏓 I’m also drawn to Stoic philosophy, particularly Marcus Aurelius, and enjoy incorporating lessons from The Daily Stoic into everyday life. “The impediment to action advances action. What stands in the way becomes the way.” -Marcus Aurelius Looking forward to connecting with applicants, residents, faculty & mentors this Match season! AAMC ID: 16315579 @MedNewsWeek @ProjectImg #IMG #ERAS #ECFMG #MedEd #HematologyOncology #match2027 #ERAS2027
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The future of cell & gene therapy won’t be defined by innovation alone—it will be defined by who can actually access it. Thrilled to be joining Technology Networks as a Featured Speaker on September 24 for a conversation at the intersection of two fields rapidly reshaping medicine: AI and cell & gene therapy. My presentation, “AI-Enabled Standardization for Scalable Cell & Gene Therapy Trial Matching,” will explore a challenge I believe we urgently need to solve: How do we take extraordinary scientific innovation and make sure the right patient can actually find—and reach—the right clinical trial? The next frontier of AI in medicine isn’t simply generating better answers. It’s building tools that can break down barriers, standardize complex decision-making, expand access to clinical trials, and help move transformative therapies from possibility to patients. That is the future I’m incredibly excited to help build. I’m deeply grateful to Dr. Arturo Bonilla for his outstanding mentorship, guidance, and belief in this work, and to Dr. Chandler Park for his continued mentorship and support. Having mentors who challenge you to think bigger—and then help you turn those ideas into something meaningful—is invaluable. And a huge thank you to Technology Networks for providing a global platform to have this conversation. 📅 September 24, 2026 11:00 AM ET Free Registration: technologynetworks.com/tn/we… If you work in AI, oncology, clinical trials, cell & gene therapy, or health equity—or simply want to see where these worlds are converging—I hope you’ll join me. The science is moving fast. Our ability to connect patients to it needs to move even faster. #ArtificialIntelligence #CellTherapy #GeneTherapy #ClinicalTrials #Oncology #PrecisionMedicine #AIinHealthcare #HealthEquity #ClinicalResearch
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Yan Leyfman, MD retweeted
1/ FDA posted the briefing docs for Wednesday's Galleri panel. I've sat on a few of these. The docs are asking a different question than the one everybody is arguing about. fda.gov/advisory-committees/…
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CML care is evolving. 🎙️ In this @MedNewsWeek × @oncodaily episode, Jorge Cortes, MD, explores modern treatment algorithms, TKIs, molecular monitoring, treatment-free remission, resistance, and AI-driven personalized care. Watch: piped.video/watch?v=dtWA2bQ2… #CML #MedNewsWeek
What does the future of CML treatment look like? 🎙️ In this MedNews Week Keynote, Jorge Cortes MD(@jorgecortesmd) joins us for an expert discussion on: The CML Evolution: Mastering Modern Algorithms in Chronic Myeloid Leukemia Dr. Cortes takes us through the changing CML treatment landscape, the decisions clinicians face in practice, and where the field is heading next. With decades of experience in leukemia research, leadership in CML clinical trials, and more than 1,000 scientific publications, his perspective brings together both the history and future of CML care. Whether you’re in hematology/oncology, research, or training, this is a keynote worth watching. 🎥 Watch the full keynote: piped.video/dtWA2bQ2nX4?is=yjW8… A special thank you to Dr. Chandler Park (@CParkMD) and Dr. Yan Leyfman (@YLeyfman) for building a platform that brings experts, clinicians, researchers, and trainees together to share knowledge across the medical community. And thank you to Dr. Cortes for sharing his time and expertise with us. #MedNewsWeek #CML #Hematology #Leukemia #Oncology
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What if the difference between two BCMA-directed CAR-T therapies lies not only in what they recognize—but in how the CAR is expressed? Cilta-cel and ide-cel have both transformed treatment for multiple myeloma. Cilta-cel’s higher efficacy has often been attributed to its unique nanobody binding domain. But the constructs differ in another important way: cilta-cel uses the EF1α promoter, whereas ide-cel uses MND. To investigate whether that difference matters, researchers analyzed CAR-T cells from 87 patients—50 treated with cilta-cel and 37 with ide-cel—using flow cytometry and single-cell multi-omics. They found that cilta-cel demonstrated approximately 10-fold greater peak expansion and increased persistence, associated with an inflammatory GZMK⁺ T-cell subset marked by EOMES expression and accessible regulatory motifs, but not by an exhaustion profile. The mechanistic experiments were particularly intriguing: in myeloma xenograft models, the EF1α promoter—not the binding domain—recapitulated enhanced tumor control, expansion, and the GZMK⁺ transcriptional profile compared with MND. The broader implication is that CAR-T performance may be shaped not only by antigen recognition, but also by the regulatory elements that govern CAR expression and the cellular states they promote. This study points to promoter selection as a potentially important—and sometimes underappreciated—dimension of CAR-T design. The next generation of CAR-T engineering may depend as much on how we program the cell as on what we ask it to target. #MultipleMyeloma #CART #CellTherapy #Immunotherapy #TranslationalResearch #CancerResearch @MSKCancerCenter @MSK_DeptOfMed @PericaKarlo nature.com/articles/s41467-0…
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🩸 CML HAS CHANGED. HAVE OUR TREATMENT ALGORITHMS KEPT UP? The era of simply choosing a TKI and monitoring response is behind us. Today, treating chronic myeloid leukemia means navigating an increasingly complex set of decisions: Which TKI should you start — and for whom? When should an inadequate response trigger a switch? How should resistance mutations change treatment selection? Where do newer agents fit into sequencing? Who can safely pursue treatment-free remission — and when? At this week's MedNews Week Keynote Conference, we go directly into these questions with Dr. Jorge Cortes, MD, one of the investigators who helped build the evidence base behind modern CML therapy. 🎙️ THE CML EVOLUTION: Mastering Modern Algorithms in Chronic Myeloid Leukemia Dr. Cortes breaks down how CML management has evolved and, more importantly, how to translate that evolution into real-world treatment decisions at the bedside. Now at the University of Alabama at Birmingham, Dr. Cortes has led 90+ Phase I–III clinical trials, authored 1,000+ scientific publications, abstracts, and academic contributions, and held major international leadership roles in CML—including leadership of the International Chronic Myeloid Leukemia Foundation. This isn't just a review of CML. It is an opportunity to learn how one of the field's most influential investigators thinks through the decisions that define modern CML care. 📅 September 16, 2026 ⏰ 12:30 PM ET 🌎 MedNews Week Keynote Conference Catch this episode exclusively on OncoDaily TV: piped.video/watch?v=dtWA2bQ2… From first-line therapy → resistance → sequencing → treatment-free remission. If you treat leukemia—or are training to—this is one conversation worth hearing. MedNews Week | Connecting Medicine Globally. #MedNewsWeek #CML #ChronicMyeloidLeukemia #Leukemia #Hematology #HemeOnc #Oncology #CancerResearch #CancerCare #ClinicalOncology #PrecisionMedicine #TargetedTherapy #TKI #TreatmentFreeRemission #ClinicalTrials #MedicalEducation #HematologyOncology #OncTwitter #MedTwitter #ConnectingMedicineGlobally @oncodaily
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Catch this episode exclusively on OncoDaily TV: piped.video/watch?v=dtWA2bQ2…
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