Professor @ UCSF l Functional genomics: gene regulation in 3D, CRISPR screens, and neuroepigneomics l Opinions are my own.
UCSF
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I’m delighted to share our latest work on the 3D epigenome of glial cell types in the developing human cortex, published today in Nature!
rdcu.be/CPbL73mz3STa
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We map glial cell-type-specific regulatory landscapes, link enhancers to their target genes, and uncover how schizophrenia risk variants and human accelerated regions (HARs) may shape gene regulation during human brain development.
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This work was funded primarily by @WeillNeurohub and conducted in collaboration with @Kriegsteinlab, @hawkins_lab, @LenPennacchio, and @yunliunc. Congratulations to our first authors @EnRachmielJones and @LiWang_neuro, and the entire team!
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Delighted to share our latest work, part of the @ENCODE_NIH project, now published in Nature Communications: nature.com/articles/s41467-0…
We uncover an enhancer-mediated allelic compensation mechanism that safeguards transcriptional stability of dosage-sensitive genes.
We @YinShenLab are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk genes in human iPSC-induced excitatory neurons using CRISPR tiling deletion screening. biorxiv.org/content/10.1101/… 1/20
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Yin Shen retweeted
🚨 Don’t forget to register for #Neuroepi25!
⏳ The deadline is fast approaching - Thursday 7th August 2025.
This is your last chance to join; don't miss out on a fantastic meeting!
Click here to register➡️ bit.ly/45dN5Ck
#FusionNeuro #FusionAgingResearch #FusionEpigenetics
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Excited to see our work on HARs highlighted by @TrendsGenetics—appreciate the feature!
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How did we evolve brains capable of learning and complex language? @IHG_at_UCSF found that parts of our DNA evolved at hyperspeed, making our brains more complex than apes’, but possibly raising the risk of human brain disorders. tiny.ucsf.edu/ZySms3
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Our latest research on human accelerated regions has just been published with @SpringerNature rdcu.be/ebo7a. Congratulations to @MarkTransposon @HanYang_Henry and the team! In this study, we characterize genome variants to function through the lens of evolution.
How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Together with Han Yang (@HanYang_Henry), our new study on human accelerated regions (HARs) sheds light on this question @ nature.com/articles/s41586-0…. 1/12
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Join us for GRC/GRS: Genome Architecture in Cell Fate and Disease this June in Ventura, CA!
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Yin Shen retweeted
🌟 SAVE THE DATE! 🌟
The 4th Neuroepigenetics & Neuroepitranscriptomics Conference is returning with its 4th edition! 🎉
Join us for this incredible event, chaired by Hongjun Song (University of Pennsylvania) and Li-Huei Tsai (MIT), in beautiful sunny St Julians, Malta! ☀️
💥 Save the date and stay updated on all the details!
👉 Sign up for updates by clicking here: bit.ly/41ibKUS
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In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
biorxiv.org/content/10.1101/…
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Yin Shen retweeted
It was both inspiring and enriching to have this remarkable and synergistic group come together for the QBI Chromatin Symposium today!
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Join us on Nov 18 at @UCSF for the QBI Chromatin Symposium, led by Drs. Vijay Ramani & Yin Shen. This event will showcase the latest in chromatin regulation, from bench to bedside. We look forward to seeing you there next week!
Register now: qbi.ucsf.edu/qbi-chromatin-s…
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New @ENCODE_NIH preprint from the lab! Through CRISPR screens, we identify functional enhancers for neuropsychiatric disease risk genes in iPSC-derived neurons. We revealed an exciting allelic compensation effect (ACE) on transcription for the dosage-sensitive gene SIN3A.
We @YinShenLab are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk genes in human iPSC-induced excitatory neurons using CRISPR tiling deletion screening. biorxiv.org/content/10.1101/… 1/20
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Yin Shen retweeted
Four last days to register! Symposium on 9/9. We have a great lineup of speakers, plenty of time to network and registration is free.
genotech.ucsf.edu/home
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Join us for our annual Genotech Symposium taking place 9/9/24 in the UCSF Mission Bay campus. The goal of the symposium is to foster interactions between industry & academia. We have an amazing lineup of speakers & registration is free of charge!
genotech.ucsf.edu/home
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Thrilled to announce our latest work in @CellCellPress! We've developed a new human neuron model that effectively mimics tau aggregate spread in tauopathy. Details here: cell.com/cell/fulltext/S0092… (1/5)
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Yin Shen retweeted
📢'The World Is Your Oyster' is for those who are born in global north countries--don't experience visa bureaucracy & emotional burden that non-white global south scholars do. Citizenship is a privilege that we need to recognize in the academe. 1/n
nature.com/articles/d41586-0…
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Yin Shen retweeted
I just ran across this and I love the author's reasoning for not using Bonferroni correction as much as we do in science.
ncbi.nlm.nih.gov/pmc/article…
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Yin Shen retweeted
How to pick a problem. Today in @CellCellPress. 1/53
cell.com/cell/fulltext/S0092…
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