Same is true for curcumin
Berberine's "poor bioavailability" is not a bug, it's a Feature This allows it to traverse the whole GI and act as an antifungal/antimicrobial throughout it as opposed to being absorbed at the beginning of the small intestine

Sep 20, 2026 · 4:31 PM UTC

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Replying to @biohackingdad
This combined with specific soluble and insoluble fibers can basically act as a sweeping cleaning antimicrobial agent in the gut, similar to the concept of the "carrot salad" Curcumin/turmeric also has this action, very, very low bioavailability (good in this context), but gentle antimicrobial action that generally preserves and promotes beneficial species, while inhibiting pathogens Could be potentially useful to combine with PHGG, heavy insoluble/soluble fiber meals like berries, carrots, other fruits/fibers, etc, or even resistant starch
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