Physician Scientist @TMO_Heidelberg, @NCT_HD & @DKFZ, #epigenomics, #DNAmethylation, #singleCell, #precisiononcology, #hematopoiesis, #JMML
Heidelberg, Germany
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Check out this tweetorial about our recent paper in @BloodPortfolio:
doi.org/10.1182/blood.202503…
🩸🩸🩸
@ASH_hematology
🧵 NEW PAPER in @BloodJournal!
Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? #AML #Epigenetics
Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇
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Daniel Lipka retweeted
🧬 Happy to share our new Perspective @NatureComms! Why can one mutation cause a childhood cancer in some cases and an adult cancer in others? The answer is developmental timing: early-life hits retain fetal programs, while later hits must rewire them. 🧵nature.com/articles/s41467-0…
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‼️ Pre-print alert from the Lipka lab ‼️
Our latest work “Hierarchical classification of hematologic malignancies using epigenetic and genetic information” is now online!
biorxiv.org/content/10.64898…
Thanks to all colleagues who contributed to this work! 🙏
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Daniel Lipka retweeted
🚨 The #ISEH2026 full Scientific Program is now available! Explore the exciting scientific content and start planning your ISEH experience in Frankfurt.
⏰ Early bird registration ends 16 July—explore the program and register now: iseh.org/Annual-Meeting/Scie…
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Daniel Lipka retweeted
Following some amazing discussions with colleagues at EHA about our recent publication in
@NatureCellBio, rdcu.be/fkASJ, here are some important points showing why considering HSC reconstitution kinetics will make you re-think the concept of lineage biases 1/9
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Daniel Lipka retweeted
📢Another exciting seminar on CCEC, scheduled on Friday 6thJun@3PM,UKtime with Alvaro Rada Iglesias @IBBTEC Cantabria.
Alvaro will discuss: Enhancer-Promoter contact, a key feature in gene regulation, how and why?? link2join us06web.zoom.us/webinar/regi…
@ShuchiChromaBio
@activemotif
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Daniel Lipka retweeted
The May #PreprintWatch is here! Explore exciting novel approaches in treating hematological malignancies, from improving cell therapies to unforeseen synergies between already discovered molecules ➡️ iseh.org/Publications/Simply…
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✨ Thrilled to share our new publication in Nature.
We define an “inflammatory memory” HSC state (HSC‑iM), linking lifelong inflammatory exposure to aging and disease.
📄 Article: nature.com/articles/s41586-0…
Grateful to an incredible team and global collaborators 💚💙
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Daniel Lipka retweeted
For the first time, we have reserved an entire session for talks selected from the late breaking abstracts.
It's not too late! The late-breaking call for abstracts for #ISEH2026 is now open. Submit your abstracts by 19 June for a chance to share your findings with world-leading scientists. iseh.org/Annual-Meeting/Abst…
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Daniel Lipka retweeted
Check out the new pre-print dissecting mechanistic regulation of mutation acquisition in HSCs during aging. Fantastic collaboration with @ATJCagan @imartincorena @sangerinstitute & Benedikt Brors and my own group @DKFZ @hi_stem_lab biorxiv.org/cgi/content/shor…
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Daniel Lipka retweeted
🔬 We’re hiring 3 Group Leaders in Paediatric Haematologic Malignancies.
🤝 @CarrerasIJC & @IRSJD_info are joining forces to launch a new translational research hub focused on paediatric blood cancers.
📝 Apply now to drive real change for young patients: f.mtr.cool/qncnupettq
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Daniel Lipka retweeted
First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @ISEHSociety exphem.org/article/S0301-472…
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Daniel Lipka retweeted
Read the March Editors' Pick:
Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia doi.org/10.1158/2643-3230.BC…
The March edition of Editors’ Picks from AACR journals includes studies on pediatric leukemia development, awareness of alcohol as a carcinogen, and more. Learn more on the #AACRBlog: brnw.ch/21x1aEw
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Daniel Lipka retweeted
We are excited to announce the release of the Human Methylation Atlas Summary and Signals tracks for hg38 and hg19. The tracks display genome-wide DNA methylation profiles across 39 primary human cell types from 205 healthy tissue samples.
Learn more at bit.ly/humanMethylationAtlas…
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Daniel Lipka retweeted
Mol Hem Workshop abstract submission now open here ehaweb.org/connect-network/e… Opportunity to present your latest unpublished work at a well attended session forming part of the @EHA_Hematology annual meeting in Stockholm
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Daniel Lipka retweeted
Grateful to @JianXuLab for this perspective highlighting how oncogenes, developmental ontogeny, and cellular plasticity intersect in pediatric leukemia, alongside the JMML study by @mp_hartmann and @dblipka1. @BCD_AACR @CD_AACR aacrjournals.org/bloodcancer…
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Daniel Lipka retweeted
Check out our latest story science.org/doi/10.1126/scie…! Huge thanks to @GauravA_UK and the @bloodgenes lab for driving this work forward together with us. This was a great team effort with outstanding collaborators @_ruslansoldatov, @AbdelWahablab, and @AlexBickMDPhD.
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Daniel Lipka retweeted
Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion
nature.com/articles/s41588-0…
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