Associate Professor, @PennGenetics @PennEpiInst 3D Genome structure and function
University of Pennsylvania
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🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
biorxiv.org/content/10.1101/…
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Eric Joyce retweeted
Patrick Walsh (@pjwalsh1688) in the @ericjoycelab defends his thesis tomorrow!
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We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit! ericjoycelab.com/oligopaint-…
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Eric Joyce retweeted
Dr. Randi Isenhart (@isenhartrandi) has a new 1st author publication for her work in the @ericjoycelab on: The length and strength of compartmental interactions are modulated by condensin II activity: dx.plos.org/10.1371/journal.…
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Eric Joyce retweeted
We are deeply saddened by the loss of an esteemed colleague, friend, mentor & a pioneer in Drosophila & meiosis research.
R. Scott Hawley was a dedicated supporter of GSA & a champion of genetics.
Read an In Memoriam published in Genes to Genomes: buff.ly/3EoNQh8
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Eric Joyce retweeted
Exciting news 📃🧬🔬 Today we report on the dynamics of a fascinating class of molecular motors, so-called SMC proteins in @CellCellPress
doi.org/10.1016/j.cell.2024.…
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Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer interactions can form de novo without loop extrusion. Alternative mechanisms, including LDB1 and YY1, may play key roles.biorxiv.org/content/10.1101/…
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ft. @HarkeJailynn, Jeewon Lee, @SonCNguyen, Staci Rakowiecki, @rebecca_yunker, @doug_epstein, @ericjoycelab (@PennGenetics), Arian Arab, @Melike_Lak (@PennEpiInst) & @SHugelier (@UPennPhysiology) @MolecularCell cell.com/molecular-cell/abst…
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Eric Joyce retweeted
Congratulations @HarshiniChandr8 💐
Using human neurons homozygously-engineered with familial AD mutations, she found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs
BioRxiv: doi.org/10.1101/2024.02.27.5…
We are excited to announce the winner of the GOA Young TAD for 2024 is @HarshiniChandr8 🏆🥇🏅 Congratulations to Harshini and also to the other finalists! The 3D genome field is in great shape with so many innovative young scientists!
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Eric Joyce retweeted
It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
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🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check rdcu.be/dZYQw, @NatureComms, @4DNucleome, @The3DGenome, @humangenomeorg, @netscisociety, @Emblebi, @MoGen_Grads
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Eric Joyce retweeted
Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion
biorxiv.org/content/10.1101/…
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First preprint from the lab 🚨
How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process?
biorxiv.org/content/10.1101/…
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Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
biorxiv.org/content/10.1101/…
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1/🧬Does chromatin organization shape immune responses? Our recent study with @NickAdams_PhD led by Reizis Lab and @leonidmirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells (cDC)👇
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Eric Joyce retweeted
📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells.
biorxiv.org/content/10.1101/…
👇Key findings:
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We then show these changes are found within tissues and during aging. To learn more, check out our preprint!
Thank you to all co-authors, the Buenrostro lab, and everyone at @HSCRB & @broadinstitute who made this work possible!
biorxiv.org/content/10.1101/…
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Speaker Spotlight: @MariekeOudelaar from the Max Planck Institute will share exciting research on the mechanisms behind 3D genome folding and its role in gene regulation during cellular differentiation. Don't miss it! Register here 👉 bit.ly/chromatin-2024 #chromatin2024
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Excited to see our paper officially out in the August issue of @CD_AACR !
Condensate-Promoting ENL Mutation Drives Tumorigenesis in vivo through Dynamic Regulation of Histone Modifications and Gene Expression, Yiman Liu, Qinglan Li, @LilingWanLab, and colleagues. @PennMedicine @PennCancer @PennEpiInst @Penn_CBIO bit.ly/4cTwIvw
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