PhD Candidate in the Kvon Lab @UCIBioSci. 👩🏻🔬🧬
California, USA
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Grace Bower retweeted
Was not prepared for the graphical abstract
Excited to share our latest manuscript in @CellCellPress. Here we discovered neuropeptides that specify and reprogram the division of labor in leafcutter ants! penntoday.upenn.edu/news/wha…
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Grace Bower retweeted
Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in @Nature. nature.com/articles/s41586-0…
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.1101/… 1/
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Grace Bower retweeted
How do non-coding variants in enhancers cause human disease?
Here, in my main PhD work with @evgenykvon, we uncover a surprising mechanism, with generalizable implications for human genomics. tinyurl.com/89tdkevu n/
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Grace Bower retweeted
The first story of my PhD out now in final published form, including new untested variants (see below)!
Our preprint is out nature.com/articles/s41467-0…
In a new set of experiments, we screened a panel of rare and common variants from patients with Autism and identified variants in enhancers of OTX2 & Mir9-2 that reproducibly alter their activity in vivo! Huge congrats to @ewholling
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Grace Bower retweeted
Beyond happy to share the most exciting findings of my PhD research in the @stark_lab. 🤩
tinyurl.com/k6rbxjwn
Our genome-wide silencer screen revealed that silencers are different from your typical regulatory DNA element.
Find out more below 👇 (1/9)
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It was exciting to dig into all the new discoveries in long range gene regulation while writing this!
In this review, @gracecbower & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their target genes rely on additional mechanisms to ensure robust gene activation during mammal development sciencedirect.com/science/ar…
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Grace Bower retweeted
Updated VISTA Enhancer Browser, 7 years in the making, out in @NAR_Open! >4,500 transgenic in vivo enhancer experiments for all your developmental biology, human variation and #evodevo needs. enhancer.lbl.gov #enhancers #embryos doi.org/10.1093/nar/gkae940
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Grace Bower retweeted
🚨Preprint alert🚨 Excited to share the #preprint version of our work @MundlosLab ! Curious about how a transposable element (TE) insertion can cause developmental phenotypes? 🧬🦠🐁
Check the 🧵 below and the full version on BiorXiv:
biorxiv.org/content/10.1101/…
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Grace Bower retweeted
Beta-version of the new VISTA Enhancer Browser, 7 years in the making, with support for developmental stages, different species and variant comparison is finally online. Feedback is welcome! vista-enhancer.lbl.gov #enhancers #embryos #evodevo
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Beyond proud of the work that went into our latest story! A big shoutout to @evgenykvon for the incredible guidance.
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.1101/… 1/
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Grace Bower retweeted
Our preprint characterizing mouse developmental Enhancer—Promoter interactions by @Czx17943830 is out today @NatureGenet rdcu.be/dBRPu
See also a complementary study on fly Enhancer—Promoter interactions from @Eileen_Furlong nature.com/articles/s41588-0…
How important is Enhancer—Promoter physical proximity for developmental gene activation? Happy to share our work led by postdoc Zhuoxin Chen @Czx17943830 where we systematically address this question in vivo. (1/n)
biorxiv.org/content/10.1101/…
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Grace Bower retweeted
How to test the functional impact of noncoding variants in vivo? Happy to share our work led by @ewholling where we developed dual-enSERT, a new method that enables rapid, quantitative comparison of human enhancer variant activities in live mice. Check this Tweetorial for details
Much of human disease-linked variation maps to regulatory regions. Yet, our ability to test the effects of these noncoding variants remains limited.
In our new @biorxiv preprint, we asked if we could begin to chip away at this bottleneck: biorxiv.org/content/10.1101/…
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Grace Bower retweeted
I’m overwhelmed by the support from the #devbio and #zebrafish communities. This trip has been really special. I met some of my science heroes (@CagneyElayna, @SolnicaKrezelL, @clawedfeet & @chrmosimann) and talked to a lot of amazing people. Tanks everyone ☺️ #2023SDB
ALT Plaque with the inscription that reads: Society for Developmental Biology Trainee Science Communication Award. Kevin Thiessen. In recognition of extraordinary science communication and outreach efforts as a trainee member of the Society. 2023.
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Grace Bower retweeted
Lots of new insights into Enhancer Biology! Special thanks to @aburger2009 for suggesting this awesome topic for an SDB satellite symposium and to all #2023SDB crew (@Lab_VPrince, Marsha, Laura and Ida) for helping with the logistics.
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Grace Bower retweeted
The #2023SDB Meeting will also kick off with the Satellite Symposium ‘Outside of Exomes: Enhancers in Development and Congenital Disease’ organized by @aburger2009 @evgenykvon kvonlab.org/sdbenhancer #2023SDBenh
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Grace Bower retweeted
(1/n) Excited to share preprint by @ViraatGoel @mileshuseyin
We develop Region-Capture Micro-C (RCMC)
By focusing on specific regions, we generate the deepest 3D genome maps thus far
We see coalescence of enhancer and promoters into “microcompartments”
biorxiv.org/content/10.1101/…
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Grace Bower retweeted
Humans can be... well... a little self-absorbed... our DNA is the MOST SEQUENCED DNA EVER!
SO. MUCH. DATA.
But are we sooooo special?!? #Zoonomia 1/n
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Grace Bower retweeted
Insertion causes muscle to bone transformation by enhancer highjacking of ARGAP36! Super cool story led by @MeloUira @MPI_MolGen with Elisa Giorgio out now in @NatureComms nature.com/articles/s41467-0… @UKSH_KI_HL @UniLuebeck @kieluni Great tweetorial below:
We are very happy to announce our latest work in @NatureComms, a great collaboration with @malte_spielmann and Elisa Giorgio. Here we show the importance of carefully analyzing non-coding DNA variants in #RareGeneticDiseases. @mundloslab @MPI_MolGen rdcu.be/c9Dkn
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