Postdoc @lydfinley lab @MSKCancerCenter interested in cellular metabolism and mitochondria 🧫 | Previously PhD @Cambridge_Uni @IMS_MRL
New York
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Beyond excited to share my first paper from my PhD @DPhaz Lab @IMS_MRL now out in @embojournal! Special thanks to Sam from @TVPLab and @dougall_norris for co-leading this project with me. We found that many cell culture models, despite living in 18% oxygen, are hypoxic! 🧵below:
embopress.org/doi/full/10.10…
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Joycelyn Tan retweeted
Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures", but their own internal data.
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Joycelyn Tan retweeted
Reasons to use an em dash:
1) reclaim it from the machines
2) you don't know what a semicolon is for
3) it has incredible vibes
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Joycelyn Tan retweeted
Out today in @cellcellpress new work from the lab led by Abby Xie and @jules_stef asks, when and why do cells use the TCA cycle?
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Online Now: Aspartate availability drives differential engagement of the malate-aspartate shuttle dlvr.it/TRB143
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This is what amino acids look like if you let the side chains flop around on the page
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I'm excited to share our latest story from the @lydfinley lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used . Out now in @NatMetabolism: rdcu.be/ejFTs 1/
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Joycelyn Tan retweeted
We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle model for studying glc metabolism and insulin action. jobs.cam.ac.uk/job/50597/ @IMS_MRL Please RT. Please email if interested.
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Very excited to finally share our work using subcellular proteomics to look at insulin-stimulated protein movement in adipocytes! 🧵below: (1/5)
biorxiv.org/content/10.1101/…
@DPhaz @IMS_MRL
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Excited to share our opinion piece on why current standard cell culture practices deserve more consideration - with implications on cell metabolism and beyond! We focus in particular on nutrient and oxygen availability. A pleasure to work with @JasonRCantor lab! @DPhaz @IMS_MRL
happy to share our forum now online @Cell_Metabolism! fun for us (@guytochondria & myself) to collaborate with @DPhaz @joycelyntsi, and Sam in putting together what we hope will be a useful piece for the broad metabolism community re: in vitro modeling!
cell.com/cell-metabolism/ful…
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Joycelyn Tan retweeted
Our latest preprint identifies (targetable!) metabolic programs intrinsic to different cancer cell states in rhabdomyosarcoma, out just in time for @kiparas21's thesis defense tomorrow!
PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma biorxiv.org/cgi/content/shor… #biorxiv_cancer
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Joycelyn Tan retweeted
no PhD in history has ever needed to say this before
Guys, I adore your enthusiasm towards reading my thesis, but please stop requesting it on the university’s depository. I can’t lift the embargo as publishers prefer/require it and I’ve been getting hundreds of emails per day for over a month. I’m really sorry!
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Joycelyn Tan retweeted
Oncometabolites at the crossroads of genetic, epigenetic and ecological alterations in cancer
nature.com/articles/s41418-0…
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Joycelyn Tan retweeted
Check out this #Resipher feature on @TheScientistLLC! It outlines the experience that @joycelyntsi, cellular biologist at Memorial Sloan Kettering Cancer Center, had with using the device to measure #OxygenConsumption rate.
the-scientist.com/a-simple-c…
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Joycelyn Tan retweeted
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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Joycelyn Tan retweeted
Hi #cancer #metabolism twitter. New review from @CognetGuillaume: science.org/doi/10.1126/scia….
Has long been understood that tumors experience metabolic stress due to nutrient limitation in the tumor microenvironment. 1/7
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Joycelyn Tan retweeted
Postdocs: we want to start a NYC "Postdoc Night Science" forum where fellows meet monthly for a drink and fun practicing the creative process together with chalk talks and brainstorming. Sign up here: docs.google.com/forms/d/1V4_…
@KelseyRMonson is helping and we need more volunteers!
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Joycelyn Tan retweeted
Imagine seeing a disease's impact on every cell in the body. Now, you can!
We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. MouseMapper showed obesity-induced changes in facial nerves & body-wide inflammation 👉🏼🧵biorxiv.org/content/10.1101/…
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Joycelyn Tan retweeted
We are looking for a Postdoc to investigate novel genes that regulate insulin-stimulated glucose transport (tinyurl.com/ycarykzh). MRC-funded collaboration with O'Rahilly (@StephenORahilly) @IMS_MRL & Langenberg groups (QMUL).
Please RT.
Link: tinyurl.com/57ea9p3f
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