A tube within a tube. Co-founder & COO @ResearchHub

Washington, DC
Patrick Joyce retweeted
Printed an Anthology of our Reproductive Health Reports that @JocelynnPearl once kindly called like a “Vogue of Science”. In re-reading them I wish our PCOS & Endometriosis issues had had more hard science, like our Ovarian Aging one. I noticed that the articles I enjoyed the most are the one from researchers talking about the science and the ones I would edit more, even my own writing, would cut the lamentations of our collective suffering. @PolinaLishko, a recognized cellular and developmental biologist, wrote one of my favorite articles because it was so matter of fact and educational on academic publishing as one of the systemic issues that keep “women’s health” research at the bottom of the barrel. I don’t think I have figured out fully how to get my peers in biotech & life sciences, and those who are passionate about solving hard technological or millennial biological problems to find the wonders of sex-specific R&D as fascinating as all else. But I’ll keep trying!
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Patrick Joyce retweeted
There are immense perverse incentives leading to extreme myopia in both academia AND startups. This is due to the inherent (deeply flawed) human desire to “claim ground” on narrow slices of a broader truthful picture that requires humble integration of seemingly disparate ideas. We need more interdisciplinary-ness and vertical integration to make the most impactful progress.
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🔬 Advancing today’s biomedical research to build a healthier tomorrow involves more than publishing research results in journal. It involves verifying those findings through scientific rigor and scrutiny, transforming promising research into discoveries upon which the world can act. To that end, NIH has launched a new reproducibility and replication initiative rooted in one clear conviction—that discovery and independent verification are inseparable pillars of science. Read more in my @ScienceMagazine editorial ➡️ science.org/doi/10.1126/scie…
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Patrick Joyce retweeted
To this day, we still don't fully understand what happens to consciousness at the boundary between life and death. A neuroscientist at @GIGAConscious (@Coma_Science) is raising $172K on ResearchHub to study how near-death experiences form, evolve, and reshape people's lives. 🧵
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Patrick Joyce retweeted
The Athanatos Foundation has launched a new funding pool on ResearchHub, committing up to $23K to independent replication studies investigating the reported effects of epothilone B on anesthetic sensitivity. 🧵
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Patrick Joyce retweeted
198,953 $RSC has been burned to date from activities on ResearchHub. Come fund more science. Science 🤝 Crypto
The first burn under RIP-23 has been completed. 🔥 • Amount burned: 71,229.48 $RSC • Source wallet: 0x7F57d306a9422ee8175aDc25898B1b2EBF1010cb • Destination (null) address: 0x000000000000000000000000000000000000dEaD •Date: 08/25/2025 This inaugural burn includes all $RSC the ResearchHub Foundation has collected from transaction fees so far. From now on: • Every week, 100% of the $RSC collected in platform transaction fees will be sent to the null address. • Burns will take place at the start of each week. • All activity is verifiable onchain. This milestone strengthens ResearchHub Foundation’s commitment to neutral, community-aligned protocol governance under RIP-23. Link to onchain transaction 👇
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Patrick Joyce retweeted
Replying to @NIHDirector_Jay
@ResearchHub would love to help! We pay peer reviewers $150 to share feedback on grant applications. It normally takes <10 days for two expert reviews!
$150 per peer review, paid to the reviewer. Every review public. Turnaround averages about 10 days. One live test of an alternative to gatekeeping review. One unsolved part: hiring and grant committees still count papers.
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NIH’s peer review process depends on the participation of experts across the research community. We’re seeking scientists with expertise in human-based research approaches to serve as NIH grant reviewers. If that’s you, I encourage you to bring your perspective to this important work. More information: bit.ly/3V2Akbn
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Navitoclax, a senolytic given after amikacin, cut intracellular M. abscessus ~190-fold in mouse macrophages. Infection made the cells senescent; in mice it cut lung bacteria, less than amikacin (one pathogen; no human trial).
Cell senescence emerges as a hallmark and therapeutic target of chronic intracellular infection nature.com/articles/s41467-0…
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Scarpa et al., Cell senescence emerges as a hallmark and therapeutic target of chronic intracellular infection, Nature Communications 2026, University of Milan and San Raffaele (M. abscessus in mouse and human macrophages in vitro, and in mice; open access). nature.com/articles/s41467-0…
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Patrick Joyce retweeted
Steve Bruehl and I had lots of fun discussing the latest VASCO results with Gadi Schwartz on NBC News last night! We talked about: - The sizes, properties and possible altitudes of the transients. - What happens if we assume that the transients are caused by objects at geosynchronous distances and project their lines of sight back onto the Earth’s surface? Intriguingly, we find hotspots around White Sands, Sedona and Tampico, as well as several locations in the Pacific Ocean west of Mexico and California. And perhaps most intriguingly: what happens around nuclear tests? If we look within ±1 day of a nuclear test, something interesting appears. Around dates when nuclear weapons were tested over the Pacific Ocean, the transients cluster over the Pacific. Around dates when nuclear weapons were tested in the Nevada area, the transients instead cluster over the southwestern United States. So the correlation with nuclear tests may not only be temporal. It appears to have a geographical component as well. Enjoy! 🙂 piped.video/watch?v=_93vhH8X… @NBCNews @GadiNBC
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Patrick Joyce retweeted
Associate Professor at @USCGero, @BBParis1984, is raising $10K on ResearchHub to test promising anti-aging drug candidates directly in human ovarian cells. The project is already 32% funded. Help get it across the finish line. Fund the research. 🧵
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Patrick Joyce retweeted
Funding Pools are live on @ResearchHub! Support @doublezero Foundation in funding neutrino research to send data straight through the Earth. researchhub.com/grant/32329/…
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Patrick Joyce retweeted
Prime assembly put 9.1 kb of new DNA into 28.1% of K562 cells with no double-strand break, and 12.1 kb into 7.4%. In resting T cells it ran at 3.3%, above the 2.2% in dividing ones. HDR needs division (cells only, no animals).
Nature research paper: Targeted genomic integration and rearrangement using prime assembly go.nature.com/3Vlrm93
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Patrick Joyce retweeted
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everyone so busy yapping about AI no one noticed room-temperature superconductor claims are back arxiv.org/abs/2609.15712
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Patrick Joyce retweeted
Thanks for the feature @InsidePhilanthr!
ResearchHub is testing a crypto-powered alternative to traditional science grantmaking, aiming to reward openness, collaboration and other practices the current system can discourage. Paul Karon Reports: tinyurl.com/btv9h7rs #ScienceFunding #Philanthropy #ResearchHub
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Patrick Joyce retweeted
Today on TSEE, we're sharing a list of 10 cool things about mitochondria. Truly amazing organelles! From their many functions and behaviors to their potential as targets for enhancing health and treating diseases, we keep discovering new features of mitochondria that reveal how much more they are than powerhouses. What is this list missing? What are your favorite mitochondrial facts and features? tseenergy.substack.com/p/10-…
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