Calì_Lab@lab_cali

Tito Calì lab @UniPadova, Full Professor @dsb_unipd. Organelle Contacts, Neurodegeneration. SPLICS and split-FPs based reporters. @Cali_Lab@mstdn.science

 Padova
pnc.unipd.it/tito-cali/
Joined March 2020
51 Photos and videos
Group photo! 👇 👇 👇 👇 👇 Alberto Elena Lucia Flavia Jessica De Covallero Poggio Barazzuol Giamogante Almeida R.
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gerry melino@melino_G
Oct 30
Accademia Lincei hosting a Cancer Meeting with Tak Mak, Arnie Levine, Raul Rabadan, Jemie Blundell…..excellent!?!!
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CDD press@cddpress
Oct 27
“Apoptotic cell overload drives multinucleated giant cell formation after neoadjuvant chemotherapy in colorectal cancer: molecular mechanisms and tumor-suppressive effects” A link between therapy-induced #CellDeath and anti-tumor myeloid remodeling ⤵️ nature.com/articles/s41419-0…
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Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells nature.com/articles/s41589-0…

Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells

Nature Chemical Biology - The chemogenetic tool Grubraw activates mitochondria by generating pyruvate in the mitochondrial matrix. This triggers a genetic switch that slows down tumor cell...

nature.com
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Structures of respiratory supercomplexes and ATP synthase oligomers in mammalian mitochondrial inner membrane nature.com/articles/s41467-0…

Structures of respiratory supercomplexes and ATP synthase oligomers in mammalian mitochondrial...

Nature Communications - Structures of mitochondrial ATP synthase oligomers and respiratory supercomplexes from sub-organellar particles (isolated from bovine heart mitochondria) offer insights into...

nature.com
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CDD press@cddpress
Oct 26
“Fhl2 promotes chondrocyte ferroptosis in osteoarthritis by impairing mitophagic flux through microtubule disorganization” Targeting these pathways may offer new strategies to limit #Ferroptosis-associated cartilage loss in #Osteoarthritis ⤵️ nature.com/articles/s41418-0…
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Cell Reports@CellReports
Oct 23
Hexokinase-2 moonlights as a suppressor of STING-mediated innate immunity dlvr.​it/TW2RBZ
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BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death | Science science.org/doi/10.1126/scie…

BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death

The apoptotic regulators BAX and BAK, once activated, form homo-oligomers to trigger mitochondrial outer membrane permeabilization (MOMP), activating the apoptosome and caspases. Activation of...

science.org
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GRP75-dependent SIMPA mediates inter-organellar quality control nature.com/articles/s41586-0…

GRP75-dependent SIMPA mediates inter-organellar quality control

Nature - Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling...

nature.com
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Calì_Lab retweeted
CDD press@cddpress
Oct 21
“Glutamine synthesis pathway promotes the survival and recurrence of dormant tumor cells in prostate cancer” This work suggests that the combination of #HormonalTherapy and GS inhibitors may overcome therapeutic #Resistance ⤵️ nature.com/articles/s41420-0…
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Per chi fosse interessato, stasera sarò con @RobertoBurioni e @fabfazio a @chetempochefa.
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CDD press@cddpress
Oct 16
“A chemical-genetic system for calreticulin exposure on cancer cells reveals immune-dependent antitumor effects” Can calreticulin exposure alone drive anticancer #Immunity? ⤵️ nature.com/articles/s41418-0…
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Lorenzo Galluzzi@deadoc80
Oct 15
Glad to share our latest @Cell_Metabolism review on #NAD #metabolism and #cancer. Kudos to Leire and @txi_ber for taking the lead on this, and thanks to Laura and Guido for constructive input. Available at authors.elsevier.com/a/1nx%7… @FoxChaseCancer @WCMResearch
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Sensing endoplasmic reticulum redox state by ethylene receptors: Cell cell.com/cell/fulltext/S0092…
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CDD press@cddpress
Oct 12
“p53 wild-type/low c-Myc-expressing ONS76 pediatric medulloblastoma cells become senescent after gamma-irradiation and can be eliminated by senolytic substances” Translating these findings to the clinic could potentially benefit the oncological outcome ⤵️ nature.com/articles/s41420-0…
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PrudentLab@LabPrudent
Oct 8
Delighted to share the last paper of the lab, published in @ScienceMagazine , uncovering a new role for Golgi-derived vesicles and phosphoinositides in regulating mitochondrial fusion! 👇👇 science.org/doi/10.1126/scie…

Golgi-derived vesicles containing PI(3,4)P2 drive mitochondrial fusion

Mitochondria are dynamic organelles that remodel their shape to regulate cell fate. Mitochondrial division involves interactions with the endoplasmic reticulum (ER), lysosomes, and trans-Golgi...

science.org
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CDD press@cddpress
Oct 7
“Chondroitin sulfate shapes the unfolded protein response in osteosarcoma to sustain cancer cell survival during ER stress” Read more about the regulatory and functional relationships between oncofetal CS and #ERStress in #Osteosarcoma ⤵️ nature.com/articles/s41419-0…
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CDD press@cddpress
Oct 6
“nHOTAIRM1 scaffolds ANXA11-dependent assemblies to drive axonal mRNA localization in human motor neurons” How do #neurons deliver specific mRNAs to distant axons? @RNAlab_IBPM uncovered how a #lncRNA can regulate mRNA sorting in human #spMNs ⤵️ nature.com/articles/s41418-0…
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What a beautiful Nobel Prize. Huge congratulations to @KarlDeisseroth , Hegemann and Nagel — and to the @NobelPrize Committee! 👏 A wonderful story of serendipity, curiosity and generous sharing. A great reminder of what curiosity-driven science and open sharing can lead to. 🔬💡
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The Nobel Prize
@NobelPrize
Oct 5
BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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Happy to see our paper, led by outstanding postdoc Alessandra Esposito, out in @Nature today. We uncovered a TBK1/ULK1 signaling pathway that acts as a lysosome quality control mechanism, regulating the FLCN-TFEB axis in response to lysosomal stress Link: rdcu.be/icEViqq6F68a
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