science enthusiasts in Pharmacology @Yale studying molecular mechanisms of cell signaling in cancer and neurodegeneration (bhattacharyya-lab.org/)
New Haven, CT
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Preprint from my lab @YalePharm uncovers the molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling using #singleMolecule #microscopy, #cryoEM, #ephys, #signaling, offering a clear blueprint to target this much sought-after pathway! doi.org/10.1101/2025.11.18.6…
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The Biological Sciences Division at the University of Chicago is conducting a division-wide, open-rank faculty search in Cancer Biology and Immunology:
apply.interfolio.com/190755
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Several of our @YalePharm graduate students recently received prestigious NIH and NSF Fellowship Awards. Please join us in congratulating them! ⬇️
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Princeton University seeks applications for an assistant, associate or full professor for the initiative at the interface between cancer, immunity, and metabolism at the Ludwig Princeton Branch. Application for Assistant, Associate, or Full Professor, Ludwig Princeton Branch
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Direct visualization of MCM helicase activation and replisome coupling in situ . We used MINFLUX to visualize MCM hexamers in human cells. A wonderful collaboration with Supriya Prasanth in UIUC, Jonas Zähringer, Oraya Zinder biorxiv.org/content/10.64898…
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WHaloForce enables chemigenetic imaging of molecular tension in living cells and animals. A wonderful collaboration with Shaohe Wang at HHMI Janelia. biorxiv.org/content/10.64898…
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Dyna-1 is now published in @Nature! Since this preprint thread 18 months ago, there's prospective experimental validation and more!
nature.com/articles/s41586-0…
Many congratulations to coauthors @ginaelnesr @DorotheeKern and the whole team!
Protein dynamics was the first research to enchant me >10yrs ago, but I left in PhD bc I couldnt find big expt data to evaluate models.
Today w @ginaelnesr, I'm thrilled to share the big dynamics data I've been dreaming of, and the mdl we trained: Dyna-1.
rb.gy/de5axp
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New paper from the lab. Using AI-guided modeling and experiments, we identified a hidden allosteric pocket in the cancer kinase PKMYT1. Led by @NHerrington24 in collaboration with @LazarusLab pubs.acs.org/doi/full/10.102…
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For those keeping track of kinases and brain diseases, LRRK2 inhibitor fails to benefit idiopathic Parkinson’s patients. Trial for PD caused by LRRK2 mutations still ongoing. statnews.com/2026/05/21/park…
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Join us in welcoming our next 2025–2026 Pharmacology Seminar Series speaker, Dr. Aashish Manglik of the University of California, San Francisco. He will be presenting his work at 12 pm on Thursday, April 16th in the Brady Auditorium.
ALT Flyer for the Yale Pharmacology Seminar Series 2025–2026. This flyer indicates that Aashish Manglik, MD, PhD will be presenting his work at 12:00 pm on Thursday, April 16, 2026 in the Brady Auditorium. Dr. Manglik is an Associate Professor of Pharmaceutical Chemistry at the University of California, San Francisco. The title of his talk is "Cracking Codes in Cellular Communication."
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March 17 is the deadline for abstract submission for Open Talks (in every session) and Travel Grants (up to 100) for our 40th Anniversary Symposium in Boston, MA. Don't miss it! Abstract fees are $15 for student members and $30, for non-members.
proteinsociety.org
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Consider applying for this Gordon conference on single molecule approaches to biology! Suliana Manley is the keynote speaker.
🔬 Calling all early-career researchers (ECRs) for the GRS Single Molecule Approaches to Biology!
🌎 Location: Les Diablerets, Switzerland
📆 Save the date: June 27-28, 2026
🔗 More information: grc.org/single-molecule-appr…
#biology #biophysics #singlemolecule #microscopy #ECR
ALT Visual advertisement providing details for the 2026 Single Molecule Approaches to Biology GRS in Les Diablerets, Switzerland in June 27-28, 2026. Two-day event for early-career single-molecule biophysicists, with a keynote session, 12 selected talks, 2 poster sessions, and mentorship component. For more information contact Alba or Quentin or see the official GRS website.
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🚨 Postdoc Position Open 🚨
Study protein-DNA interactions w/ cutting-edge single-molecule imaging in our lab!
Exciting projects perfect for ANRF-NPDF apps. Motivated postdoc candidates: Approach us!
Mahipal Ganji
ganji@iisc.ac.in
ganjilab.org
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Super cool work! I can see so many applications!!! Congratulations 🎉
Starting 2026 with Quan Pham's paper expanding the chemical toolbox for engineering AAV
- New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment
- Incorporation of two different chemistries for dual capsid labeling & much more:
onlinelibrary.wiley.com/doi/…
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Delighted to have our work on 🧬 resilience to 🩸cancer led by @GauravA_UK & amazing collaborators, including @KharasLab, published in @ScienceMagazine: science.org/doi/10.1126/scie… 🧵
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In the latest issue! Inhibition of oligomeric BAX by an anti-apoptotic dimer dlvr.it/TQ2MJy
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Super excited to share our latest finding on the EGFR activation mechanism. In our paper, we found that cholesterol in the inner leaflets of the plasma membrane is essential for ligand dependent EGFR activation.
science.org/doi/10.1126/scia…
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Preprint from my lab @YalePharm uncovers the molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling using #singleMolecule #microscopy, #cryoEM, #ephys, #signaling, offering a clear blueprint to target this much sought-after pathway! doi.org/10.1101/2025.11.18.6…
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Our findings have outsized implications for selective targeting of #ChronicPain without adverse effects on trophic signaling OR treatment of #neurodegeneration without eliciting dose-limiting pain. A detailed step-by-step description of this preprint is coming soon!
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FDA approves 100th small-molecule kinase inhibitor nature.com/articles/d41573-0…
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