I run @PopVaxIndia (popvax.com) – we develop mRNA vaccines and therapeutics using computational protein design. I write at infinitesunrise.com

Hyderabad / Mumbai
On August 31, the first two participants were injected with @PopVaxIndia’s first fridge-stable RNA vaccine candidate in a Phase I clinical trial in Australia. We built this vaccine at our RNA Foundry in Hyderabad – from computational design to GMP manufacturing. Here's how:
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Sid blazing the trail for personalized cancer care as always!
We’ve just made public 125,091 DICOM radiology images from across my cancer journey (link below). The data is both longitudinal and multi-modal, dated and linked to my treatment timeline, so you can compare imaging across initial diagnosis, standard of care, first remission, “founder mode cancer care”, and second remission. It’s viewable in OHIF, the standard open-source viewer used in radiology research. Given the long history of applying deep learning to radiology, we’re hoping to see a variety of methods and models applied to my data. If you find something interesting, please reach out to cancer@sytse.com, or if you know a researcher who should see this, tag them below. Thanks to Terra LaFerriere for organizing these images, and Kamil Slowikowski for building osteosarc.com into the resource it is.
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Soham Sankaran retweeted
Anthropic gave me $30,000 in Claude credits to research my own tumor I wrote what I built since March. I’m looking for someone who can manufacture a personalized vaccine, and a hospital that can give it
Article

Anthropic gave me $30,000 in Claude credits to research my own tumor. This is what I built.

Ten days ago I got an email from Anthropic. My project got into their AI for Science program, with $30,000 in Claude credits. Thank you to everyone in the program for supporting this 🫶 The project is

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Social media users must be given copy of takedown order: Punjab and Haryana High Court Read here: barandbench.com/news/social-…
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Young men being detained for days, and then held further, for waving our national flag in our national capital is a travesty of justice, one of many we've all been cursed to witness over the past week -- including the strikingly sad developments around the Ankita Bhandari case.
#BREAKING Special Executive Magistrate Court extends CJP leaders Saurav Das and Ashutosh Ranka’s judicial custody for two more days. @Cockroachisback @SauravDassss @AshutoshRanka
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I, too, am ill this week and, in my state of advanced delirium, was planning to write about it, but then realized Nihal already has!
I write briefly about my ongoing recovery from a viral infection. nihalsahu.net/ageing/
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Never hire in desperation. Ever.
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We all know Uncle. For years, Uncle has performed samajik seva for the Society, and also society itself. He protects us from those scurrilously renting flats to bachelors, couples holding hands, and returning home after 11:15pm. Now, Uncle has selflessly agreed to tell his story to inspire the youth. Revenge of the Uncle is a 20-minute mockumentary we are making about the nation’s greatest unsung social activist and his efforts to win himself a Padma Shri (of course, only if Hon’ble Home Ministry thinks he deserves it). My brother @SahajSankaran and I are looking for a cast & crew to help make it happen! We’re planning a week-long shoot before the end of the year. You can read the cast & crew call + the draft screenplay here: honestyisbest.com/p/revenge-… If you're interested, you can book an appointment to speak with us here: calendly.com/sahajsankaran/n… Want a taste of what we've done before? Watch The Project, a comedy pilot we wrote & directed about a group of villagers who start a fake consulting firm to save their village from demolition (note that The Project is satire!):
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@MumbaiPolice why is Carter Road closed off on a Sunday with no notice? On whose authority do public servants close access to roads without informing citizens?
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Soham Sankaran retweeted
Degraders were on the front page of the Friday edition of the WSJ Business and here's a little context for people like my dad who are not bio focused. Drugs that target proteins usually work by binding the protein of interest and preventing it from working properly. But, degraders work by connecting the protein of interest to a junk processor called E3UL. The degrader brings the junk processor to the disease-causing protein and essentially makes it way more likely that the disease-causing protein is going to get tagged by the junk processor for destruction. And actually, thalidomide was the first degrader, except we didn't know it at the time. It was offered as a morning sickness antidote in the late 1950s but was later recalled after it caused birth defects. Decades later in the 1990s, it came to be used in multiple myeloma after clinical trials showed it worked well. It was a backbone of treatment. Its derivatives are still the cornerstone of myeloma treatment regimens. Despite its use in the clinic, we didn't really know how it worked and that it was a degrader until 2010. Knowing how a drug works biochemically doesn't always come before figuring out if a drug works for patients. Back to degraders. Degraders attack proteins that live INSIDE cells. Proteins that cause disease that exist inside cells are infinitely tougher to target than proteins that live on the OUTSIDE of cells. For example, antibodies can attack proteins that live on the outside of cells and we as humans have gotten quite good at making antibodies. The cell is a place packed full of billions of molecules buzzing around participating in billions of reactions. Degraders bring two things into proximity to force a specific single process to occur amidst the chaos. Degraders are a specific instance of a general class of drugs called molecular glues that act to bring a disease-causing protein into close proximity with something else in order to treat disease. Daraxonrasib, the pancreatic cancer drug that has doubled overall survival, is a molecular glue that brings together KRASG12X (disease-causing protein) and CYPA so that CYPA blocks access to KRASG12X.
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Soham Sankaran retweeted
I asked Gemini 4 Argon to make a video using 100 images to represent 'humanity' - if we were to send it to space to be found by aliens. Every frame is generated using javascript with p5.brush via @GoogleAIStudio. Gemini team really cooked with this. Starting with cave paintings, iconic paintings, moon landings to creation of AI. There are instances of human feelings, biggest achievements, historic moments and everything in between. Some take longer to recognize but the more you look at, the more beautiful the whole creation becomes. How many can you recognize? (watch with audio)
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Soham Sankaran retweeted
Prosperiti's newsletter on the laws constraining Indian competitiveness is continuously excellent. There are so many well-intentioned laws that protect workers in theory, but in fact make it impossible to compete globally. No firms, no workers.
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Soham Sankaran retweeted
Matches SOTA on miniprotein binding prediction
Coin labs is announcing our new decision model Flip-1. - Distilled down to 1 parameter - 50% on yes/no bench - Runs fully offline
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Neil is absolutely right!
Every few years there is a new current thing in tech. Sometimes, India will fall behind, and whenever that happens, everyone around: those in the government or adjacent (ministers, regulators, other bureaucrats, etc.), those in the industry (investors, founders, engineers, etc.), and miscellaneous thought leaders (billionaires, policy think-tank people, influencers) all inevitably panic and start asking how India will catch up. Today, the current thing is AI, India has fallen behind and the same questions are coming up again. With this begins a very predictable sequence of events. The whole ecosystem goes through the seven stages of tech grief. 1. Disbelief ("India is obviously the IT capital of the world"), 2. Denial ("India has cheap labour, so we don't need AI"), 3. Anger ("All because of bloody brain-drain and Indian founders just doing D2C and grocery delivery"), 4. Bargaining ("India should build on top of existing AI, be the use-case capital of the world"), 5. Depression ("Maybe we should all just move to SF, invest in founders with a US visa or in American companies"), 6. Testing (India AI Summit, India AI Mission, Government starts investing in companies like Sarvam, funds invest in international brown people), 7. Acceptance ("Indic AI will be the global frontier tech leader of the Global South"). The saga ends with everyone coping, and hoping India will be a different place soon, fully ready for the next wave. But nothing much changes. The real answer, especially for a democracy with India's scale, is that if you know you need to catch up, it's already too late. Meta can go founder-mode, spend big, hire big and make a great attempt. China can redirect a bunch of human capital (smart people) and corporate capital (balance sheets) to solve it and get close too. But what do you do in a country like India? What the India should do is let the market, with all its messy constituents: individuals, founders, talent, institutions, universities, investors; both good and bad -- run free. The most well-meaning panel of bureaucrats cannot optimally allocate compute, a conference of regulators and incumbents will not bring frontier talent to the country, government handouts to already quite large funds are a waste of taxpayer money, and governments investing in early stage companies causes premature king-making and throttles competition. The State can do a lot, but it has start with doing less. What does that mean? It means taking a step back, and removing all hurdles to increase the flow of capital, talent, and risk. It's the only way India will retain capital, technical talent, and risk-takers for long enough for compounding to kick in, and benefit from it as a country. You make capitalism easier. This includes reducing the compliance burden pushed onto a company (further outsourcing to CAs and lawyers doesn't count), but also making it easier to raise as a company, easier to invest as an investor, reducing paperwork for everyone (digital disclosure forms are also paperwork), etc. Startups are not unique kinds of entities requiring any special laws, registration and benefits. Startups are just companies. The same kind of ease of doing business should apply for everyone. If you're worried about tax evasion, remove all tax breaks. When it matters the most, startups don't make a profit anyway. Will some bad apples try to game the system and get away with it? Sure. There will always be bad apples. You let it go, because the long-term benefits outweigh all short term costs by orders of magnitude. Even the IPL -- our one crown jewel in the world of sport, had corruption, match fixing, auction rigging, and a bunch of other shady business early on. You fix it later. No sane person would go back in time and shut down IPL before the second season because of problems at the time. Innovation is delicate. If we think in decades, progress will follow. Many of these things are already solved elsewhere, there are global benchmarks we should strive to beat. Our competition is not just an India of 20 years ago, but every other country we lose innovation to. We are losing, make it easier for those who will help us win. In case this is too vague, here is what we should aim for: 1) bring down company incorporation time to <1 week, 2) bring down time to close investments <1 day, 3) bring down time to open a corporate bank accounts to <1 day, 4) minimise the total number of hours a month a promoter has to spend in non-tax compliance, 5) bring down the number of hurdles to export goods and services. Part 2 to follow soon, where I will try to list out a hundred small things that will help fix this. My DMs & comments below are open: for any recommendations from those facing adjacent problems, for anyone who would want to collaborate on these, and especially for anyone inside the Government interested in our feedback.
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Siddhant is both brilliant and uncommonly kind! He is a key full-stack biologist @PopVaxIndia, working fluidly across design, wet lab experimentation, bioanalytical methods, data analysis, and software infrastructure. We are hiring a passionate & rigorous scientist for his team!
P.S. AI protein design gets the headlines. Whether the thing in the tube is actually what you designed gets decided by analytical methods. My team at @PopVaxIndia is hiring an analytical scientist for protein characterisation (SEC-HPLC) jobs.popvax.com/41532
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Soham Sankaran retweeted
I'm looking for technical scouts to find the world's best researchers whose dreams don't fit into academic lab- or venture capital-shaped boxes It is, first and foremost, an ideas job. Flexible on work arrangement. Technical vision must be first-rate. freaktakes.com/p/help-wanted…
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Soham Sankaran retweeted
Very moving to see @MTamfum & Peter Piot arm in arm, receiving the @virchowprize for discovering & fighting Ebola. Side note: Luckily, we now have safer equipment than thermos flasks for shipping viral samples. That's how the key sample traveled from DRC to Belgium 50 years ago!
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We are living in a wild new reality! Old assumptions about difficulty and marginal utility no longer apply.
What a bizarre future. I wanted to play Halo: Combat Evolved for the first time with @robertskmiles, and we wanted local multiplayer across two screens, and a model could just immediately add that feature to the decompilation.
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PopVax's initiation of our first clinical trial has been covered in the Mint by @_jesthetic! livemint.com/companies/start…
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