Out of the top 100, I have watched 7 in full (The Office, Arrested Development, The Americans, Lost, Black Mirror, Homeland, and The OA). Perhaps embarrassingly, I have never seen even one episode of any show in the top 10.

I wish drug discovery were like pure math where, even if the problems can be fiendishly hard, they are bounded and closed with a well-defined solution and can be solved with pen and paper or with a computer. But unfortunately drug discovery (and biology more generally) is not like math. It's not even like physics, as I wrote about many years ago. A good reminder in the age of AI. wavefunction.fieldofscience.…

When an older heart is transplanted into a younger person, it doesn't stay "old." Vadim Gladyshev's lab shows the heart actually starts aging on the timeline of the body it's now living in — its biological age shifts to match the recipient, not the original donor, at the molecular level. biorxiv.org/content/10.64898…

new inquiry work from us and @stuartbuck1 (@GoodSciProject) + @Josh_A_New (@SeedAIOrg) originally written to influence "null results" policy at NIH newsletter.goodscienceprojec…

"A true friend is the greatest of all blessings, and that which we take the least care of all to acquire." Francois de La Rochefoucauld

Seeing Like a Gardner, cited in the latest National Academies report today analogue.press/p/seeing-like…

thrilled to share that @jainhiya_ is joining @analoguegroup to lead analogue press and our inquiry work she’s taking on two things that feel increasingly central to what analogue is becoming with analogue press, she’ll build a home for the original research, essays, field notes, conversations, and intellectual artifacts emerging from across analogue. we’ll publish our first print edition soon too, bringing together some of the remarkable research we’ve funded so far on inquiry, she’ll lead our work on the institutions and mechanisms around research itself—working closely with @stuartbuck1 and @GoodSciProject on experiments in how science gets funded, new institutional design, partnerships with other organizations, and helping institutions become better patrons of ambitious research in a sense, she’ll be working on both the ideas and the environments that allow those ideas to exist there is a huge amount i’m excited for her to build here! hiya made a pretty extraordinary choice to join us, which i’ll let her tell you about herself in an essay soon :)

Just published this guest column about a huge White House vs. NIH battle that no one has yet publicly noticed: newsletter.goodscienceprojec…

If it's isn't obvious already, it is the end of papers as a measure of productivity, expertise or accomplishment. The odds of publishing in "glam" conferences & journals also very quickly approaches random & the time for gate keeping review increasing exponentially. 1/

I could be wrong, but I suspect that any system that is capable of recursive self improvement won't be a true general intelligence in the first place. nytimes.com/2026/09/16/scien…

1/ It’s time to share more about what we’ve been working on: @common_fabric is a social computing lab building a medium for software that revolves around people, not apps. commonfabric.com

Terrible line of reasoning confusing heavily empirical domains like biology with theory like solving Navier-Stokes. An AI-engineered extinction virus within the decade is no more plausible than AI curing cancer within the decade, no matter how smart it gets. The data don't exist.

NSF X-Labs is expanding pathways for institutions & teams to advance innovative science and tech critical to U.S. competitiveness. Today, NSF announces 3 new topics: AI for Physical Systems, From Sequence to Function, & Computation at the Limit of Physics. brnw.ch/21x5JSo

Former OSTP Director and professor at the Institute for Advanced Study, plus a distinguished scholar at Penn: science.org/doi/10.1126/scie…

A great reminder of just how primitive the information system really was on 9/11. Even though it was just 25 years ago, it’s really like another world Cheney - the VP of the US - is forced to watch updates from New York just like I did, on a little TV that’s physically wired to the wall Bush in Air Force One was actually out of communication for much of the day. Both he and Ari Fleischer talked about this. There was no email or satellite TV. Cable news was intermittent as they flew in and out of range of terrestrial broadcast antennas. He might have well been on the Moon

THE BIPARTISAN SENATE SCIENCE AND INNOVATION CAUCUS. @SenMcCormickPA

my talk from last week~ analogue.press/p/the-price-o…

This paper helps to develop an important use case for AI tools in research, namely auditing a paper's adherence to a pre-analysis plan. 1/9