Anthropic and OpenAI released cheaper models on the same day with Claude Opus 5.5 and GPT-6. Dave McClure of Practical Venture Capital, Jeff Clavier of Uncork Capital, and Jenny Fielding of Everywhere Ventures join Jason to debate what that means for open-weight models. They also get into why fintech and healthcare are suddenly on the VC sideline, whether Meta's Muse leaves any room for Instinct, why it's a buyer's market for secondaries, and why median seed valuations have more than tripled since 2017.
@jason @davemcclure @jeff @jefielding
0:00 What seed rounds looked like then: Fitbit's $2M seed
3:15 Jenny's Techstars NYC years and the two-unicorn mug
7:51 All-In Summit: Trump calls Jensen Huang onstage. Staged or not?
8:56 P(doom) roundtable + Dave's AI sovereign wealth fund prediction
10:08 Northwest Registered Agent - Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at
northwestregisteredagent.com…
13:35 The AI intel error that nearly triggered a US-China incident
17:44 "McClure's Law": a human with AI is the real risk
19:59 Odoo - The all-in-one business platform. Your first app is free! Get started today at
Odoo.com/twist
21:37 Stripe + OpenRouter: an anti-fraud play, not a routing play?
23:07 Seed valuations: median $8M (2017) to $28M today
23:58 Instinct: $2.5B to a reported $10B in weeks
29:49 Rippling - Thanks to our partners at Rippling! Head to
Rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business.
44:01 Opus 5.5 vs. GPT-6 Sol: the same-day price war
46:51 Gun to your head: open-weight models or frontier labs?
51:00 Secondaries: the top 30 names vs. everyone else
52:30 Why fintech and healthcare are unloved (and Jason's Robinhood bet)
🎥 Watch the full episode here 👇