Postdoc @ University of Melbourne/Peter Mac | cancer biology x cell cycle x epigenetics x CDK2/4/6i
Melbourne, Victoria
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A nice follow-up to our recent @Nature paper (@BarbMarte).
Nature has published a News & Views piece discussing the work: “The secret life of a cell-cycle gatekeeper of cancer.”
Very proud of the team. Interested to hear where these concepts go next.
nature.com/articles/d41586-0…
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Delighted to share our new paper, published today in @Nature , led by @AprilCWatt and @AntonioAhnNZ at the @PeterMacCC and The University of Melbourne @uommedia
Paper: nature.com/articles/s41586-0…
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Excited to share our work, now in @Nature! Delighted to have co-led this study with co-first author @AntonioAhnNZ under the supervision of @shomgoel at @PeterMacCC @PeterMacRes and the University of Melbourne @uommedia
Open access:
nature.com/articles/s41586-0…
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April Watt retweeted
Peter Mac researchers from @shomgoel's lab have uncovered why breast cancer treatment stops working for some patients.
Published in @Nature, the discovery could help develop new treatment combinations that work for longer and improve outcomes.
More: petermac.org/about-us/news-a…
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April Watt retweeted
Congratulations @AprilCWatt on a great talk at @SABCSSanAntonio. Provided the first real explanation of why CDK4/6 inhibitors and endocrine therapy work together, with major implications for understanding resistance and therapy development.
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April Watt retweeted
Congratulations @AprilCWatt on a great talk at @SABCSSanAntonio. Provided the first real explanation of why CDK4/6 inhibitors and endocrine therapy work together, with major implications for understanding resistance and therapy development.
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April Watt retweeted
Happy to share our new study describing the effects of CDK2 inhibition in solid cancers. It has been a fun and stimulating collaboration with @incyclixbio and fantastic to work with INX-315, their selective and potent CDK2 inhibitor.
doi.org/10.1158/2159-8290.CD……
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April Watt retweeted
‘How is your PhD going?’ nitter.net/buitengebieden/status/…
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April Watt retweeted
Can we expand the potential of existing cancer therapies through strategic drug schedules & combinations? Read our perspective on harnessing the immunotherapeutic activity of CDK4/6 inhibitors for combo therapies
nature.com/articles/s41698-0… @PeterMacRes @Nature_NPJ #precisiononcology
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April Watt retweeted
Here's our perspective on targeting CDK4/6, just published in Nature Reviews Cancer @NatureRevCancer @PeterMacRes @UniMelbMDHS @SnowMedical. CDK4/6i's have transformed breast cancer therapy, but we have still only realised a fraction of their potential! rdcu.be/cJhFx
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Check out our latest review on CDK4/6i in HR+ #breastcancer, published with @SpringerNature in @BCRJournal. We cover research on mechanisms of action beyond cytostasis, summarize current knowledge on acquired resistance, and more… @shomgoel rdcu.be/cIkE0
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Congratulations @shomgoel ! Looking forward to all the exciting research the team will be able to embark on
Thank you to @SnowMedical and the visionary Snow family for this once-in-a-lifetime opportunity. I am honoured to be named a Snow Fellow and know that this will be life changing for me and my team. Congratulations also to @meleckmas and @DrMarinaPajic!
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April Watt retweeted
Enhancer redundancy in development and disease go.nature.com/2KhuvTq #Review by @evgenykvon, @WayMaxxed, Mario G. Elabd & @zebabw
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April Watt retweeted
Many thanks to Antoni Hurtado for the detailed and insightful discussion of our lab's recent research. @NatureCancer @krknrm @UniBarcelona @PeterMacRes nature.com/articles/s43018-0…
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April Watt retweeted
The epigenetic basis of cellular heterogeneity go.nature.com/37g8Hir #Review by Benjamin Carter & Keji Zhao
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April Watt retweeted
I couldn’t just walk past this Tweet, so here is some fun #dataviz
Scented candles: An unexpected victim of the COVID-19 pandemic 1/n
ALT 3 R-generated graphs: 1) Top 3 unscented candles 2017-2020 reviews: rating (1-5) on the y axis; date on the x axis; the scatterplot shows a relatively flat line across the three years. N = 1,118 2) Top 3 scented candles 2017-2020 reviews: rating (1-5) on the y axis; date on the x axis; the scatterplot shows a relatively flat line that drops off sharply after January 2020. N = 11,404 3) A bar chart with 11 bars (January-November 2020). Proportion of reviews mentioning lack of scent on the y axis; month on the x axis. January = 2%, February = 3.5%, March = 2.8%, April = 4.6%, May = 3.4%, June = 2.4%, July = 3%, August = 3.2%, September = 3.1%, October = 5.8%, November = 5.8%.
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April Watt retweeted
Need a read for the weekend? #SpecialIssue on Methods: #scRNAseq of human milk-derived cells, a novel & non-invasive framework for investigating physiology of human #lactation by @JMartinCarli & @MikeRudolph20.
link.springer.com/article/10…
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April Watt retweeted
Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging dlvr.it/Rm4tR0
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April Watt retweeted
In #breastcancer, CDK4/6i stimulates AP-1 to activate classical super-enhancers that drive luminal differentiation & apoptotic evasion, as well as enhancers overlying endogenous retroviral elements that are enriched for proximity to IFN-driven genes: nature.com/articles/s43018-0…
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Pleased to share our work on the epigenetic effects of CDK4/6 inhibition in breast cancer @NatureCancer. A fruitful collaboration between the @shomgoel Lab at @PeterMacCC @PeterMacRes and our colleagues @CFCE_DanaFarber @DanaFarber. Thread below.
nature.com/articles/s43018-0…
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Many, many thanks to my co-first authors @palocejas and Molly DeCristo, as well as Henry Long. This work was only possible bc of your dedication and teamwork.
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Thank you @MAFD110, @enidylam, @gilan_omer, @charles_bell92 for your work on this project and helping me find my footing at Peter Mac. Finally, thank you @shomgoel for everything esp your excellent leadership on this project.
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