We identify FKBP5 as a key regulator of myeloid-driven neuroinflammation in #MS 🔬 Elevated in CSF monocytes & microglia from MS 🧬 Inhibition boosts myelin clearance & reduces IFNγ signaling 🐭 SAFit2 improves EAE outcomes #JournalofNeuroinflammation rdcu.be/e3zGN

Single-cell atlas of transcriptomic vulnerability across brain disorders idp.nature.com/authorize?res…

The nucleoside analog kamuvudine-9 shows protective and therapeutic efficacy in a mouse model of multiple sclerosis | @ScienceTM science.org/doi/10.1126/scit…

Anti-CD40L prevents meningeal B cell aggregates and mitigates progressive autoimmune encephalomyelitis academic.oup.com/brain/advan…

Oligodendrocytes in central nervous system health and disease @CellCellPress cell.com/cell/fulltext/S0092…

"How...peripheral activation relates to [CNS] lesion formation remains to be established. These findings nonetheless suggest that EBV reactivation, when...within genetically predisposed peripheral immune environment, is a proximal precursor of MS relapse." doi.org/10.1038/s41591-026-0…

Immune Profiling after treatment with an Anti-CD19 Chimeric Antigen Receptor T Cell Therapy in Treatment-Refractory Progressive Multiple Sclerosis Exciting new work from @SashGups , Bruce Cree and colleagues! medrxiv.org/content/10.64898…

She lived to 117 — the oldest verified age ever recorded — and her body told two completely different stories at once. Maria Branyas had the telltale signs of extreme aging: razor-thin telomeres and an inflamed immune system. But she also carried something rare: low inflammation, a gut brimming with beneficial bacteria, and cells that were biologically younger than her 117 years. Because she never developed a major disease, researchers led by Dr. Manel Esteller at the @CarrerasIJC (Josep Carreras Leukaemia Research Institute) could finally study aging on its own, without illness clouding the picture — the most detailed biological deep-dive ever done on a supercentenarian. Their conclusion, published in Cell Reports Medicine: extreme longevity might not mean dodging aging altogether, but surviving it while holding onto the right protective traits. Curious what those traits were? Read the full study here: sciencedaily.com/releases/20… #Longevity #AgingResearch #Geroscience #Epigenetics

✅ PTSD ✅ Bipolar ✅ Depression ✅ Anxiety ✅ BED ✅ ADHD ✅ PMDD All gone. 12 weeks. No medications. Just therapeutic ketosis with professional and group support. #metabolicpsychiatry #ptsd #adhd #mentalhealth @ikrt_org frontiersin.org/articles/10.…

Acute stress and suppression of eating, the vagus nerve rides again. Connecting the hypothalamus and the GI tract, inducing dysmotility. Mouse model. cell.com/neuron/abstract/S08… @NeuroCellPress

Menopause and “leaky gut”: implications for midlife women’s health: doi.org/10.1172/JCI209807 Brandilyn A. Peters @EinsteinMed comments on Shieh et al.: doi.org/10.1172/JCI205059

@Novartis had a rough week but this was a major win. If you told me 10 years ago a BTK inhibitor would work in MS I may not have believed it. biopharmadive.com/news/novar…

Reports that two children died after receiving gene-editing treatments in separate clinical trials in China have put a spotlight on the country’s fast-track trial pathway go.nature.com/4d8qnPF

Emergency department utilization was consistently elevated in the 5 years before #MultipleSclerosis recognition, predominantly due to non-neurologic and non-specific presentations. Study from @DMCBrainHealth @UBC ▶️ journals.sagepub.com/doi/ful…

We published the paper in @Nature journals related to multiple sclerosis, and this is my ***first-author Nature paper*** doing bioinformatics analysis/modeling in medicine. Link to my first-author paper from Nature journals (Nature Immunology) here 👇: nature.com/articles/s41590-0…

Intestinal infections establish antigen-specific, long-lived memory CD4+ T cells in the brain and meninges nature.com/articles/s41593-0… @NatureNeuro

The cortisol spike from exercise suppresses the next cortisol response from a stressor. Exercise before stressful things.

New online! Cortical lesions in multiple sclerosis: 25 years of progress, remaining challenges and future directions dlvr.it/TVMfK2

A video shows a patient with progressive multiple sclerosis attempting to walk before and after treatment with JY231, an off-the-shelf lentiviral vector designed for the direct in vivo engineering of CD19-targeted CAR T cells. Learn more in the preliminary results of a phase 1 trial: nej.md/4zPPwbD

meu Deus, eu não terei mais vida

Schizophrenia: disrupted blood immune-gene networks, jumping genes in the hubs. Important paper from Doug Nixon and colleagues @FeinsteinInstitutes Reyes-Gopar et al, JCI jci.org/articles/view/203491