We study how immune mechanisms affect physiological brain function & the onset of neurological diseases. @davalos.bsky.social these days
Ohio, USA
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Dimitrios Davalos & Lab retweeted
Excited to share our new manuscript in @NatureMicrobiol uncovering a novel mechanism by which viruses orchestrate their survival in the host. We show that #HIV inherently induces the formation of a latent reservoir of viruses, guaranteeing its long-term survival 🧵 #HIVresearch
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Dimitrios Davalos & Lab retweeted
Findings by researchers @pryprk @palakmanchanda4 @DavalosLab, Gaurav Chopra, et al. show that excess fat in the brain’s resident immune cells, #Microglia, impairs their ability to combat disease. Learn More in @ImmunityCP 👉 cell.com/immunity/abstract/S…
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Thank you for giving life to our sketch Emma! Until next time!
A real pleasure collaborating with you and the team, @DavalosLab @pryprk — congratulations on the publication! Looking forward to future opportunities to work together again ✨
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Microglia: Super-heroine that had a DGAT2-blocking beverage (cans) so she could break the chains from lipid droplets holding her back (weights) & lift the amyloid load (beams) that trapped the neurons, thereby rescuing them in the aged Brain (City sign)! #NotTheCover @ImmunityCP
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But blocking or reducing DGAT2 (using a cool new drug developed by @chopralab ) restores microglial phagocytosis of Aβ and thereby reduces plaque load and neuronal damage in a preclinical model of #Alzheimer’sDisease.
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Emma Vidal brought our concept to life.
For more info about the cool science produced in the @chopralab and ours, that inspired our geeky illustration, please read the paper here: cell.com/immunity/abstract/S…
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Dimitrios Davalos & Lab retweeted
Super proud to have been part of this work between the @chopralab and the @DavalosLab that is now published @ImmunityCP !!! Thank you @pryprk, Palak Manchanda, and all authors for this extraordinary collaboration!!!
Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Check out our manuscript @ImmunityCP 👇🏼
cell.com/immunity/abstract/S…
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Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Check out our manuscript @ImmunityCP 👇🏼
cell.com/immunity/abstract/S…
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Tremendously grateful to an amazing team of lab members and collaborators including @pryprk , @EviPaouri , Palak Manchanda and Gaurav @chopralab and pretty much all Chopra and Davalos Lab members for the smooth teamwork @ClevelandClinic @CCLRI @PurdueUnivNews
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It was💯fun to co-author this commentary w/ Katerina & other current & former fibrinogen mates from @AkassoglouLab for Cell’s 50th anniversary neuroscience issue: @CellCellPress: Pioneering discovery and therapeutics at the brain-vascular-immune interface: cell.com/cell/fulltext/S0092…
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Dimitrios Davalos & Lab retweeted
Great hosting @fib390_396A for our @CCLRI department seminar tomorrow, awesome dinner with @DavalosLab @2Scottish talking about all things platelets and thrombosis - looking forward to the seminar tomorrow morning at 10 AM, NC1-202
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Dimitrios Davalos & Lab retweeted
Are you doing exciting mechanistic science or translational work? Join us in #Miami! We are looking for independent investigators at all levels! @ASBMB @thepostdoctoral @AACR Faculty Positions - U of Miami @umiamimedicine nature.com/naturecareers/job…
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Dimitrios Davalos & Lab retweeted
C. David Allis and Michael Grunstein won the 2018 Basic #LaskerAward for discovering how histone modifications influence gene expression. ow.ly/8O4W50SKpsz @RockefellerUniv @UCLA
In just 5 days, we reveal the scientific breakthroughs recognized this year. #Lasker2024
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Amazing new study @nature showing that fibrin drives lung inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with acute COVID-19 and long COVID! Congrats @AkassoglouLab & collaborators!
Our new paper is out @Nature We report that fibrin drives toxic inflammation, impaired viral clearance & neuropathology in #SARSCoV2 infection treated by #fibrin antibody
#LongCovid #Coagulation #Immunotherapy #fibrinogen #COVID19
nature.com/articles/s41586-0…
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Dimitrios Davalos & Lab retweeted
Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday
nature.com/articles/nmeth.40…
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Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism! @NeuroCellPress Many congrats and thanks @cprofaci, Richard Daneman & great collaborators! cell.com/neuron/fulltext/S08…
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Dimitrios Davalos & Lab retweeted
708 GB image of the Moon
[📹 Darya Kawa Mirza / daryavaseum]
nitter.net/i/status/1818208770851…
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Dimitrios Davalos & Lab retweeted
10 years ago today, the @ClevelandClinic #mobilestroke treatment unit launched setting up a new paradigm for stroke care. Very proud to celebrate this important anniversary! Thank you to everyone who makes this great care possible everyday .
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