Assistant Professor @ZuckermanBrain @ColumbiaBiochem. Lab uses cryo-EM & biophysics to study the cellular, molecular, and structural basis of neurodegeneration.
New York, NY
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Thanks to #qed for including our preprint entitled "Amyloid-mediated RNA uptake by sperm for embryonic delivery" in the most compelling preprints of 2025!
biorxiv.org/content/10.64898…
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Fitzpatrick Laboratory retweeted
Blood vessels in the brain deteriorate in Alzheimer’s, especially in APOE4 carriers. But what drives this damage?
Our new study, out now in @CellPressNews , uncovers a mechanism linking APOE4 to vascular fibrosis and amyloid accumulation in the brain. 🧠🧬
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The work was led by Luca Fusar Bassini, together with my friend and co-senior author Gioele La Manno and a superb team across our labs. Paper: nature.com/articles/s41586-0… @Nature @EPFL_en #lipids #ScienceTwitter
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Very exciting! Many congratulations @SaraZaccara and team!
Excited to share our new preprint! 🎉
Using base-editor screens, we reveal how individual residues within the intrinsically disordered region of YTHDF2 control protein interactions, condensate recruitment, and m⁶A-dependent mRNA decay.
biorxiv.org/content/10.64898…
🧵👇
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Online now! Cryo-electron tomography of functionally validated synapses in human induced neurons dlvr.it/TVY02m
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RNA dysregulation as a determinant of aging and neurodegenerative vulnerability
cell.com/trends/cell-biology…
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Defining the electrical synapse — a Review by Alberto E. Pereda & Adam C. Miller
nature.com/articles/s41583-0…
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What if the stuff attached to tau fibrils affect their pathogenic structure? We found that repositioning polyubiquitin remodels pathological tau filaments, linking PTMs to tau strain biology. Huge credit to Dr. Ryohei Watanabe for leading this work.
nature.com/articles/s41594-0…
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Scientists may have identified one of the mysterious molecules that pack into the cores of tau fibrils. A chemical that modifies polyubiquitin changed core structures, suggesting polyubiquitin is part and parcel of the tau fibril. ow.ly/k5vr50ZMNzE
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Nature research paper: Connectome analysis of a cerebellum-like circuit for sensory prediction
go.nature.com/4yiv1D0
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1/ Today @BigHatBio announced that the first patient has been dosed with BHB810 — the first BigHat drug to reach the clinic.
A huge milestone for the company, and a personal one for me.
bighatbio.com/news/bighat-bi…
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Excited to share the lab’s first publication, co-led by talented postdoc Chuyi Su @ChuyiSu
We leveraged cell type-specific optogenetics in the macaque cerebral cortex to elucidate the role of excitatory and inhibitory neurons in visual form processing.
nature.com/articles/s41467-0…
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The quick progression of a thunderstorm moving across the Hudson River into lower Manhattan and One World Trade Center from NJ, seen from the Empire State Building in New York City, Friday evening #newyorkcity #nyc #newyork #thunderstorm
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A thunderstorm passes over lower Manhattan and One World Trade Center in New York, seen from the 102nd floor of the Empire State Building, Friday evening #newyorkcity #nyc #newyork @empirestatebldg #thunderstorm
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Fun paper - by looping mRNA into circles they trap ribosomes to go round and round synthesising very very long proteins. They even get E.coli and B.sub to secrete these monsters. biorxiv.org/content/10.64898…
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Join speaker Chi-Min Ho @Columbia at #CS3Dbiologicalfunction2026.
Chi-Min’s research integrates structural biology approaches to investigate host-pathogen interactions in malaria parasites.
Extended abstract deadline: July 27, 2026
hubs.li/Q04p7b7x0
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Fitzpatrick Laboratory retweeted
What a beautiful artistic imagining of our structure! I really love your take on our boat theme ❤️⛵ Thank you so much for featuring us @fenguita, we in the @cmholab are huge fans of your work!!
CryoEM structure of the Plasmodium falciparum moving junction staple - PfAMA1, PfRON2, PfRON4, PfRON5 (PDB code: 9YGJ) Paper: cell.com/cell/fulltext/S0092… #molecularart #plasmodium #membrane #cryoem #RON #AMA1 @mimi1inh @dzine_ai @proteinimaging
behance.net/gallery/25214688…
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New findings from @cmholab @ColumbiaMed on how malaria parasites invade human cells yield proof of concept for new antimalarial drug phys.org/news/2026-06-malari… via @physorg_com
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The @cmholab @ColumbiaMed solve decades-old mystery of how malaria parasites invade human cells, via @EurekAlert! eurekalert.org/news-releases…
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Fitzpatrick Laboratory retweeted
Incredibly proud of Messi Haile @mehsehret, a @cmholab founding member, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in
@CellPressNews ! tinyurl.com/4p3md2eb 🦠❄️🔬
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