Assistant Professor @ZuckermanBrain @ColumbiaBiochem. Lab uses cryo-EM & biophysics to study the cellular, molecular, and structural basis of neurodegeneration.
New York, NY
- Tweets 3,290
- Following 5,015
- Followers 3,352
- Likes 5,463
Pulsed #lasers integrated with #cryoEM: @FitzpatrickLab @ColumbiaBiochem @ZuckermanBrain postdoc Daniel Du aims to boost contrast for near-atomic detail in #cryoET @ChanZuckerberg
zuckermaninstitute.columbia.…
zuckermaninstitute.columbia.…
elifesciences.org/reviewed-p…
1
5
23
1,767
Many thanks to @Structure_CP @CellPressNews for highlighting our research:
cell.com/structure/fulltext/…
1
14
1,443
New "Mindscapes" exhibit @ZuckermanBrain featuring #cryoEM structures of #TMEM106B #amyloid fibrils (doi.org/10.1016/j.cell.2022.…) & the ligand-bound human sweet receptor (doi.org/10.1016/j.cell.2025.…) from the Fitzpatrick (fitzpatrick-lab.org) & Zuker (zukerlab.com) labs.
2
4
34
2,942
Forward-looking preview by @WUBin10069342 to our latest paper @Structure_CP by @AndrewNChang highlighting the power of #AI in #cryoEM of patient-derived samples:
tinyurl.com/tu2fyvme
Paper:
tinyurl.com/3cycffzm
Thanks to @pixelbaumarkt @Intein for #crYOLO, & @cryosparc
2
9
29
3,576
New preprint from @DuXDaniel @FitzpatrickLab shows #femtosecond light pulses can lens electron beams, promising higher contrast in #cryoET and better aberration correction in #cryoEM
biorxiv.org/content/10.1101/…
Experiments made possible by support from @cziscience #ImagingTheFuture
3
12
43
4,679
Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors
Now, an exciting collaboration between our labs @ColumbiaBiochem reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online @CellCellPress!
sciencedirect.com/science/ar…
10
70
252
18,181
It was a pleasure to host Professor Wolfgang Baumeister and share the latest results on developing an #ultrafast #laser #phaseplate for #cryoEM and #cryoET from @FitzpatrickLab @ColumbiaBiochem @ZuckermanBrain
2
9
92
6,078
For all #cryoEM practitioners in #NYC, @FitzpatrickLab is excited to host Prof. Wolfgang Baumeister next Thursday with attendance open to all and no registration necessary.
Hope to see you there!
1
7
41
3,560
Savoring a farewell butcher's feast for our visiting scientist, Julia Pichler from @FU_Berlin, at @cotesteakhouse with @andrewnchang, @carolynlinlee, @william_mallen and @FitzpatrickLab.
It has been wonderful hosting you, Julia! We hope to see you again next summer.
11
970
Direct interaction between a pulsed #laser beam and #ultrafast-timed #electron packets in free space may enhance contrast in #cryoEM and #cryoET
The latest cool image of this experiment from @DuXDaniel @FitzpatrickLab @ColumbiaBiochem @ZuckermanBrain
3
42
2,518
Guests from Europe always bring delicious lab gifts (particularly the
Haselnussgeist...)
Welcome to @FitzpatrickLab, Julia Pichler of @FU_Berlin!
8
982
If you are attending @GrcIdp in Les Diablerets, check out poster #11 during Wednesday's session! Superstar grad student @william_mallen from @FitzpatrickLab @ColumbiaBiochem @ZuckermanBrain will be presenting his latest research on #condensates #IDP #amyloid using #cryoEM #cryoET
1
2
18
2,559
Summer research begins @FitzpatrickLab @ColumbiaBiochem @ZuckermanBrain with undergraduate researchers from @Columbia @BarnardCollege @Princeton making exciting discoveries!
12
975
Many congratulations to @m_simjanoska who found time to make contributions to multiple papers from @FitzpatrickLab @ColumbiaBiochem, spent a Summer in @LabStahlberg @EPFL, has now graduated from @Columbia and is off to @harvardmed for graduate school in the @BBS_Harvard program.
2
4
36
4,216
Our latest #preprint on the development of an #ultrafast #laser #PhasePlate for #cryoET:
biorxiv.org/content/10.1101/…
#femtosecond #laser #optics #UEM #SEM #cryoEM experiments made possible by generous support from
@cziscience #VisualProteomics #ImagingTheFuture
1
7
59
7,789
Groundbreaking study from @mimi1inh and all members of @cmholab combining in situ #cryoET and #proteomics to determine the antimalarial activity of inhibiting translation in #cryoFIB-milled #malaria parasites:
biorxiv.org/content/10.1101/…
#cryoEM #massspec #teamtomo #modeofaction
10
75
6,843
Great to be back in the Bay for the @cziscience imaging 2023 annual meeting! Amazing #science, inspiring talks, dynamic discussions, and a chance to (re)connect with #ImagingScientists from around the world who are #ImagingTheFuture
14
1,977
And that's a wrap for #ACA2023! Thanks to all of the speakers in the "New developments in #cryoEM & #cryoET" session @eddiepryor13 @AdrianKoh8 @nani_grotjahn @rgsheld Shawn Zheng @cziscience Zbyszek Otwinowski @UTSWNews @sonyahans with especial thanks to @Anchi2Cheng as co-Chair.
4
33
5,226
Many congratulations @andrewnchang on being co-awarded the ('23) prize for most outstanding biological research by a graduating senior:
tinyurl.com/e2k33bs8
He joins @FitzpatrickLab alums @tamtaarakhamia ('22) & @christinalee587 ('21) as recipients of this prestigious award.
3
22
5,058
Saturday morning #coffee @nycsolidstate showing impressive #CoffeeArt on a delicious #latte (with a copy of Seitz & Turnbull on the shelf)
@gonenlab how does this compare to @espressoprofeta @ucla (the local favorite of @FitzpatrickLab & @mimi1inh @cmholab when we lived in #LA)?
2
9
2,953
Many thanks @rita_strack @naturemethods for highlighting @DuXDaniel @FitzpatrickLab #ultrafast #LaserPhasePlate for #cryoET @CellRepMethods:
nature.com/articles/s41592-0…
bit.ly/fitzpatricklabmethods
#femtosecond #laser #cryoEM experiments made possible by generous support from @cziscience!
2
3
35
6,360
@DuXDaniel @m_simjanoska @FitzpatrickLab @ZuckermanBrain @ColumbiaBiochem discuss the feasibility of resolving #proteindynamics in processes ranging from #optogenetics to #photosynthesis using a combination of #microED and #UltrafastElectronMicroscopy:
doi.org/10.1016/j.jsb.2023.1…
3
11
1,167
Excited to share the structural basis of pH-activated #endocytosis by LRP2 using #cryoem now online @CellCellPress:
tinyurl.com/mud8856c
Great collaboration with Andrew Beenken @theGABcerutti Jonathan Barasch @ColumbiaKidney @lawrenceshapiro @ZuckermanBrain @ColumbiaBiochem
14
51
254
53,529
Lights on(!) coincides with our first #ultrafast #LaserPhasePlate for #cryoET paper by @DuXDaniel @CellRepMethods #OpenAccess:
bit.ly/fitzpatricklabmethods
#femtosecond #laser #optics #UEM #SEM #cryoEM experiments made possible by generous support from @cziscience #ImagingTheFuture
1
10
44
7,835
When feeling homesick, what a nice surprise to find that a student (twitterless Zhilin Luo) has brought lots of @Fortnums tea from #London for everyone to enjoy in @FitzpatrickLab
2
1
11
2,084
Had a wonderful visit to @Cornell (and Ithaca Falls in the Fall) courtesy of @kellogg_liz and enjoyed learning about the amazing work her lab is doing to elucidate the molecular mechanisms of #transposons using #cryoEM!
1
16
What a wonderful week @CUBoulder! Huge thanks to @Aydinlab for hosting and to @alexmgreer @jccameron777 @vignesh_k757 and twitterless Michael Stowell and Roy Parker for stimulating discussions. Cutting-edge #cryoem and infectious enthusiasm for #science happening at 5,318 feet.
22
Good to be back @ZuckermanBrain after aquaplaning from Newark airport to Manhattan following a great trip to the UK! Many thanks to @BeneschResearch for hosting me @BiochemOxford in the amazing Dorothy Crowfoot Hodgkin Building.
14