Why do muscle fibres shrink with age? Not because myofibrils get smaller — because there are fewer of them. We followed this from whole-muscle down to individual myofibrils, in humans and mice, across ageing and disuse. Tweetorial below Open Access here: physoc.onlinelibrary.wiley.c…

What an exciting story!

Excited to share our new study, spearheaded by talented former graduate student Kübra B. Akkaya-Colak! Stearoyl-CoA desaturases regulate intestinal stem and progenitor cell metabolism and function in response to nutrient abundance: Cell Reports cell.com/cell-reports/fullte…

Profound and heartfelt thanks to the over 100 contributors who made this epic 3-volume, >1600 pages landmark academic treatment of aging biology, longevity therapeutics, and the science, technology, and policy of life extension possible, including @NirBarzilaiMD, @sjayolshansky, @biogerontology, @davidasinclair, @j_n_justice, @RaianyRomanni, @drmichaellevin, @ydeigin, @aubreydegrey, @TinaWoods, @JamesPeyer, @Danbelsky, @Dr_Bischof, @LidskyPeter, @MarkHamalainen, @DToddWhite, @marcpbernegger, @MattYousefzadeh, @M_S_Ringel, @LeeYuta45307, @HeWei16027, @DrGlorioso, @AnmolMD, @adamgries, @gblander1, @ProfValterLongo, @LammingLab, @DomiWilczok, @LPiolopez, @pgerwill, @KarlPfleger, @BernardSiegel, @Yu_Xuan_Lu, @Rcmsiow, @cordeiro, @Scinquisitor, @TinkingGumbel, @romanbauer111, @KeithComito, @soniaarrison, and many more. Special thanks to my fellow Co-Editors, @MaxRangeley, Regina Monaco, and David Wood (@dw2), whose intellectual leadership, editorial rigor, and sustained commitment helped transform an ambitious vision into a coherent three-volume landmark work. It was a privilege to shape this project alongside them.👨‍⚕️

Another great discussion of protein in Scientific American @sciam scientificamerican.com/artic… - with a mention of @mariahcalubag recent valine restriction paper as well!

Branched chain aminos (e.g. leucine & valine) help build muscle but also activate mTOR. Here, Lamming & team report that restricting valine extends the lifespan of male mice 23%, indicating high protein diets deserve scrutiny from a longevity perspective 🐭

Valine restriction improves metabolic health in mice, promotes leanness and glycemic control across ages, and reduces frailty, cancer prevalence and senescent cell burden in both sexes while increasing median male lifespan by 23%. By @LammingLab et al. #DR nature.com/articles/s43587-0…

I am delighted to be able to share the latest study from the @LammingLab, “Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice” led by former graduate student @mariahcalubag!