Macromolecular Complexes in DNA Damage Response Group. Structural Biology Programme @CNIOStopCancer
Madrid, Spain
- Tweets 127
- Following 94
- Followers 714
- Likes 93
starting to understand the structural bases of CONCR lncRNA in DNA replication and chromatid cohesion. A collaboration between @MaiteHuarteLab @FMorenoHerrero @OscarLlorcaCNIO @ChillonIsabel and the support of @FundlaCaixa
Online Now: CONCR lncRNA organizes a 3′-end structural domain that engages DDX11 for DNA replication and sister chromatid cohesion dlvr.it/TVD6XG
1
5
8
489
A closer look at the mechanism of microtubule nucleation💫. Thrilled to share our new work revealing CM1-activated gTURC. Great collaboration with @sernarina, @DeBritoClaudia, Thomas Surrey and @LudersLab.
@CNIOStopCancer
@CRGenomica
@IRBBarcelona
nature.com/articles/s41467-0…
4
13
1,252
Our take on the struture of the R2T complex 🌱 Now out in @Structure_CP!
A fun collab led by @alopezperrote and the @AlabadiDavid lab at @IBMCP .
Check it out in the next post 👇
1
8
14
795
The γTuRC saga goes on!
This time, we used cryoEM to describe how CDK5RAP2 helps nucleating microtubules by activating the γTuRC nucleator.
Another tour de force led by @sernarina and Fabian Zimmermann and a fun collab with @LudersLab @IRBBarcelona.
authors.elsevier.com/c/1jpyq…
3
20
57
6,926
Join us in sunny Madrid☀️ on May 2025 for "Machines acting on DNA and RNA" at the @CNIOStopCancer
All things D/RNA! 🧬Replication + transcription + translation + chromatin + repair + processing🧬
Org: @OscarLlorcaCNIO @rfleiro @NogalesLab
+info below 👇
1
14
32
5,319
Full info, speakers and registration deadlines in: cnio.es/en/eventos/machines-…
1
2
312
Llorca lab retweeted
📢Buscamos persona interesada en realizar la tesis doctoral @CIB_CSIC. Ofrecemos contrato predoctoral de 4 años (FPI) para estudiar los mecanismos moleculares de la transposición del ADN usando crio-microscopía electrónica
#PIF2024
+ info: csic.es/es/formacion-y-emple…
RT por favor 🙏
16
12
2,032
Junior Group Leader positions for AI/BigData, cancer-oriented researchers are available at @CNIOStopCancer. Many fields (Structural Bio, Protein Design, Genomics, Imaging...) are welcome! 🤗
Apply using the link below 👇 and help us spread the word!
cnio.es/en/empleo/junior-gro…
1
19
15
2,687
Thrilled to share our last work @CellRepPhysSci Revealing the molecular mechanism of an anti-tumoral compound inhibiting our favourite system, RUVBL1/2 (at 2.4 Å resolution)🔥
All-@LlorcaLab work led by @CarmenBePaper and @alopezperrote
Link below 👇
doi.org/10.1016/j.xcrp.2024.…
5
16
44
2,736
And also... 🔥pre-print alert🔥
We take a look at our favourite system in plants🌱, the R2T complex, an HSP90 co-chaperone.
A study led by @alopezperrote (@CNIOStopCancer) and Alberto Palacios (from @AlabadiDavid's lab at @IBMCP).
Check it out 👇
biorxiv.org/content/10.1101/…
9
16
1,389
🔥Paper alert🔥
Another fruitful collaboration with our friends in M. Palacín's lab. Link below 🔗👇
A study led by María Martínez Molledo (@CNIOStopCancer) and Josep Rullo (@IRBBarcelona) elucidating the cryoEM structure of Asc1/CD98hc transporter.
Supported by @FundlaCaixa
2
6
17
1,408
And here goes the link to the paper in @NatureComms 📰
nature.com/articles/s41467-0…
2
5
374
Llorca lab retweeted
Hi, we have uploaded a preprint on @bioRxiv_biochem that you may find interesting. It's the result of a fruitful collaboration (@IBMCP) with @LlorcaLab (@CNIOStopCancer) aimed at understanding the role of the HSP90 cochaperone R2T in plants.👇
2
5
18
1,455
Double celebration today in the lab! 🎉
Today, our senior postdoc María I. Daudén received the "AECC researcher" grant, followed by our undergrad Celia Varela, also receiving the "AECC lab internship" grant. Proud of you!
#TodosContraElCancer @ContraCancerEs @ContraCancerMad
5
18
980
Llorca lab retweeted
🧬REGISTRATION OPEN🧬
✈️Come to the @CNIOStopCancer for our Molecular
Chaperones in Cancer and Protein Quality Control meeting.
☀️Visit sunny Madrid during spring and enjoy our amazing lineup of speakers. Do not miss it, 10-12 June!!
cnio.es/en/eventos/molecular…
8
13
2,930
PAPER ALERT🔥
We took a deep dive into the microtubule 🔍 using cryoEM ❄️🔬to capture the earliest steps of nucleation by the γTuRC complex. With @sernarina and @DeBritoClaudia leading the way.
Proud of our collab with the @surrey_lab at the @CRGenomica !
science.org/doi/10.1126/scie…
7
22
55
4,275
We are so incredibly proud of @sernarina. Not only is she a cryoEM powerhouse, but she's also a caring mentor and labmate. Definitely a role model. Thanks for your hard work 💕
4
8
29
2,157
When your paper gets into @ScienceMagazine we take the red carpet out in the lab...
3
4
36
648