🚨New @LyssiotisLab paper led by Dr. Megan Radyk in @NatureMetabolism "NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions" 🧵Follow for a tweetorial... and bonus highlight of @LabVousden co-published study and News & Views link from @WellenLab!

We’re proud to announce @kevansf as the recipient of the $1M Stephenson Global Prize for Pancreatic Cancer Research. His work helped turn “undruggable” KRAS into a target, opening possibilities for people facing pancreatic cancer. And his work is far from finished 🏆

🆕 ADVANCE ONLINE 🆕 CANCER METABOLISM REVIEW: Lysosomal metabolism in pancreatic cancer and its crosstalk with host physiology By Cheng et al. and Costas Lyssiotis ➡️ ow.ly/2Mjl50ZRavt @DJCalebC @Chinnaiyanlab @LyssiotisLab #pancreaticcancer #metabolism #lysosome

Very happy and and honored to have gotten the chance to write this review with my friend Rüya and my mentors @LyssiotisLab @Chinnaiyanlab! It summarize much of the literature foundation of my PhD and highlights work from amazing scientists that have come before. Check it out!👇👇

New paper from Stephanie Dougan @DanaFarber_Hale with @NobelPrize David Baker in @CellCellPress! CD4 T cells convert transient responses to KRAS inhibition to durable remissions in #PancreaticCancer cell.com/cell/fulltext/S0092… Synthetic cytokines for the win! #AACRPan26

A Mayo Clinic team just built the cleanest causal test I've seen for NAD's role in aging. They engineered mice whose NAD synthesis depends entirely on dietary niacin, then pulled the niacin. Result: kyphosis, muscle and bone loss, cataracts, frailty, cellular senescence, shortened lifespan. Put niacin back and most of it reverses, without fully restoring NAD. That partial-restoration gap matters. It says NAD depletion triggers senescence programs that do not simply snap back when the cofactor returns. We flagged senescence as a load-bearing hallmark in the Biomarkers of Aging Consortium work (Moqri et al., Cell 2023); this is a rare in vivo model that makes the causal chain from cofactor to senescence to phenotype explicit and reversible. Nat Commun, Benitez-Rosendo, Chini et al. doi.org/10.1038/s41467-026-7…

Proud of our @nyulangone Dean (and prior @Perlmutter_CC Director) Alec Kimmelman for his @Nature paper today: Hepatocytes promote liver metastasis of #PancreaticCancer by providing serine nature.com/articles/s41586-0… With @BarDafna @RichPossemato @KoelinaG @nyugrossman

🟡 SCOOP: The Trump administration is backing off its initial plan for an executive order that would give the president greater influence over decisionmaking on National Institutes of Health grants. semafor.com/article/09/23/20…

A breakthrough in pediatric brain cancer research from #UMichPath! Researchers led by first author Siva Kumar Natarajan, PhD, identified a previously unknown vulnerability in ZFTA-RELA ependymoma, uncovering how itaconate helps sustain the tumor-driving fusion oncogene. Published in Nature: michmed.org/AmenK Read more: michmed.org/mKRdv

We found an adrenergic iron–MSRA axis that regulates methionine redox signaling and adipose browning. Disrupting MSRA preserved tissue mass and prolonged survival in tumor-bearing mice. Huge congrats to Jung Seung Nam, who led this work! nature.com/articles/s43018-0…

Barack Obama at his last press briefing with reporters, 2017: "I have enjoyed working with all of you. That does not, of course, mean that I've enjoyed every story that you have filed, but that's the point of this relationship. You're not supposed to be sycophants. You're supposed to be skeptics. You're supposed to ask me tough questions. You're not supposed to be complimentary, but you're supposed to cast a critical eye on folks who hold enormous power."

In the latest @USnews Best Colleges rankings, U-M was named the best public university value in the state of Michigan and ranked third among all public institutions nationwide. myumi.ch/VDgGj #GoBlue

How do cells die? What used to be thought were 2 ways, now it's >20 nature.com/articles/d41586-0…

When men have daughters, they become more supportive of women. Data on every worker in Denmark over 25 years: After male bosses welcome their first daughter, they're 2.9% more likely to hire qualified women—and pay them 4.4% more—without any cost to firm performance. But we shouldn't have to wait for men to have girls before they become feminists. It's time to replace "As a father..." with "As a human being..."

In honor of Chad's birthday this weekend, CJ and Tommy Carr are raising funds for DIPG research to help give other children the future their brother was denied. Make a gift here: runsignup.com/cjandtommycarr #ChadTough #DefeatDIPG #ChadCarr | @13Cjcarr @TommyCarr03

The irony of it all. Yesterday, @NEJM posted a new essay suggesting that the US government attacks on biomedical science will now subside. nejm.org/doi/full/10.1056/NE… On the same day, it was announced the President wants control of NIH funding. reuters.com/business/healthc…

Hail to the Victors! 〽️

“The greater danger is allowing uncertainty to convince us to stop building, mentoring, investing in ambitious ideas, supporting vulnerable communities, or imagining a future worth creating until conditions improve.” #ScienceWorkingLife scim.ag/4dxT88v

This month, a Michigan woman used a brain-computer interface (BCI) to speak with @matthew_willsey, the neurosurgeon who implanted the device in June at @umichmedicine, as part of a team from the Department of Neurosurgery. nytimes.com/2026/09/14/well/…

Another step forward in targeting RAS. A new @NatureMedicine phase 1 study of GFH375/VS-7375, an oral drug designed specifically for KRAS G12D, showed tumor shrinkage in about 1 in 3 heavily pretreated patients with pancreatic or lung cancer. In pancreatic cancer, median PFS was 5.5 months and median OS 9.9 months. About a third of patients had grade ≥3 treatment-related side effects. While the recently approved daraxonrasib targets multiple RAS mutations, this drug is selective for KRAS G12D. Still early, but another encouraging approach against a historically difficult target.

Cysteine excess triggers a mitochondrial iron-dependent cell death dlvr.it/TVV53x