Genes to functions. Microbiome in health & disease. Computational biology. Chemical biology. Innate & adaptive immunity. broadinstitute.org/xavier-la…
Cambridge, MA
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We teamed up with @HLahdesmaki to develop and validate PepGen, the first fully generative model capable of synthesizing MHCII peptide binders conditioned on allele, partial sequences, and continuous affinity
Read the results here: academic.oup.com/bioinformat…
@broadinstitute
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New preprint from our collaboration with @CarolineUhler at @broadinstitute on TissueFormer, a new tool for predicting spatial gene expression from histology images at cellular resolution
biorxiv.org/content/10.64898…
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Out now in @NatureMicrobiol: Marie Pust and colleagues developed metastrand, a tool to quantify
strand-specific transcription in microbiomes at gene-level resolution, and used it to reveal
microbial adaptations associated with IBD.
nature.com/articles/s41564-0…
#metastrand #IBD
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First author Marie is now the Group Leader in Microbiome Studies at the Kennedy Institute of Rheumatology, @UniofOxford – Congratulations, Marie!
@broadinstitute
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New work with @LabMedoff online now!
ADAMTS14 regulates YAP-driven fibroblast activation in IPF. We define an ADAMTS14–collagen V–focal adhesion pathway that contributes to #fibrosis, highlighting ADAMTS14 as a potential therapeutic target.
doi.org/10.1093/ajrccm/aamag…
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Building on our previous lung atlas, which identified pathogenic CTHRC1-high #fibroblasts enriched within fibrotic niches, this study further defines the molecular mechanisms that drive IPF.
doi.org/10.1016/j.xgen.2025.…
@MGBResearchNews
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Check out this @NatureMedicine Comment about the importance of studying heritage diets and the World Diet Initiative’s efforts to translate dietary diversity into health benefits for the global community:
nature.com/articles/s41591-0…
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Join us and @GeneLayInst on July 31st for the Annual Symposium! This year's speakers include Marco Colonna, Shimon Sakaguchi, @stefanispranger, and @victora_lab. Register using the QR code in the flyer!
#inflammation #immunity #disease #genelayinstitute
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It's that time of year again--we are saying goodbye to more of our youngest and brightest lab members as they transition to the next steps of their careers, either in grad school or in other institutions. This week, we are saying goodbye to Anna, Regan, and Tanvi.
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New website launch for the World Diet Initiative—an international effort to map global dietary patterns and their impacts on human health.
The site is now accepting heritage diet submissions to build the open-access World Diet Atlas.
worlddietinitiative.org/
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Congratulations, @SachaLEBON on some great work! Excited to see this come out after all your hard work.
My first first-author paper is (finally) out !
Big shoutout to my amazing co-authors from @bitonm lab, @matanhofree lab and collaborators from @WeizmannScience, @IRB_Department and @HebrewU community for their contributions !
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Xavier Lab retweeted
Early-life interventions & airway microbiome
Nasal microbial gene atlas in infants w/cystic fibrosis. Hypertonic saline inhalation reshapes microbiome, selects salt-tolerant H. influenzae & ⬆️transporters linked to antibiotic tolerance @TheXavierLab
cell.com/cell-host-microbe/a…
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Xavier Lab retweeted
What the nose knows of cystic fibrosis microbes and hypertonic saline
Bouzek Previews work by @TheXavierLab presenting microbial gene atlas of nasopharyngeal swabs in infants w/cystic fibrosis & healthy controls & IDing impacts of clinical interventions
cell.com/cell-host-microbe/a…
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Excited to share this new preprint from a large collaborative effort using #exome + #genome sequencing, moving beyond GWAS to implicate 68 genes in #IBD through rare protein-coding variation.
bit.ly/43h72GA
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Excited to share our new @ImmunityCP review, discussing how advances in functional genomics and chemical biology are enabling the translation of IBD genetics into mechanistic understanding and new therapeutic hypotheses.
cell.com/immunity/fulltext/S…
#IBD #inflammatoryboweldisease
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Out now @cellhostmicrobe! In collaboration with @RuthSteinbaer and Swiss clinicians, we built the largest nasal microbial gene atlas in infants w/ and w/o cystic fibrosis to date (cont.)
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We found and validated in vitro that early-life perturbations (hypertonic saline inhalation therapy) can select for microbial traits linked to salt and antibiotic tolerance.
#antibiotics #cysticfibrosis #microbial
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Our latest work, with @MikaKivimaki lab, now online @alzdemjournals: we used single-cell and GWAS data to uncover genes in peripheral blood immune cells associated with Alzheimer’s disease.
doi.org/10.1002/alz.71282
@broadinstitute
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#Alzheimers
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New work with @CarolineUhler, now online in @NatureComms! We developed TRIM, a multimodal framework integrating T cell RNA and TCR profiling to predict T cell responses to cancer treatment.
nature.com/articles/s41467-0…
@broadinstitute
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