Debating tech’s future is better in person! On March 27th, we’re hosting our annual Salon, a four-sided debate on topics that impact our future. This year, we’re trying to get to the bottom of what sector the next $1T company will emerge from… AI Superintelligence, Infrastructure, Biotech & Healthcare, or Consumer. If you’re a builder or operator in one of these areas, come represent your sector and help us see the future through your eyes. We’ve got a few spots open, so make sure to RSVP below. lu.ma/q9so7pux

TSV portfolio company @dbnlAI was just put on @BuiltIn 's 2025 best startups to work for remotely (and in SF) list! Perfect time to share that they're hiring for 2 roles 🔥 Distributional: Building the modern enterprise platform for AI testing to make AI safe, reliable, and secure. 1️⃣ Senior Front End Software Engineer (4+ years of experience, remote) 2️⃣Senior Full Stack Software Engineer (4+ years of experience, remote) Apply here: distributional.com/careers/

It's not every day that your portfolio company's technology brings a new human life into this world! Major congratulations to @DinaRadenkovic and the entire @GametoGen team for hitting such an important milestone on your path to helping more families access IVF and making fertility treatments shorter, less invasive, and more accessible for all! Read more about the first Gameto birth below

Scent teleportation is here. Games now build themselves in real time as you play. Menopause treatment gets funding to target the source, not symptoms. @Osmo_Labs teleported scent across their lab & taught computers to smell - first ever working digital olfactory system that can capture & recreate any scent. Plus, their public beta just dropped: imagine any scent in natural language, they'll bring it to life in their lab & send it to you @Etched launched Oasis - the first fully AI-powered game - generating & running entire playable worlds in real-time, creating new environments as you move @GametoGen secured $10M from ARPA-H to advance their menopause program Ameno - moving beyond symptom treatment to address root causes and help women maintain quality of life long-term TSV portfolio absolutely sprinting into the future this week 🔥🔥🔥

"With six people, we built, from scratch, the fastest laser melting platform on the planet... We did things people said you couldn't do." - Erik Palitsch, @freeform_future CEO / Co-Founder Since meeting the team, we've been blown away by their ability to execute - combining AI, supercomputing, and advanced sensing to completely reimagine metal 3D printing. Their momentum continues with today's exciting news –– a $14M raise from @nvidia and @Boeing! They're hiring across engineering and operations - check them out if you want to help shape the future of manufacturing! 👩🏻‍🏭 freeform.co/careers

A tiny chip, almost too small to see in the photo, could be the key to improving the speed, cost, and success rate of drug development. We got a firsthand look when @Terray_Tx's Jacob Berlin visited to share his vision last month. This nickel-sized chip (or microarray) is generating biological datasets 50x larger than public sources. Huge congrats to Terray on their $120M Series B funding round led by Bedford Ridge Capital and NVentures! As @endpointsnews reports, Terray is using this data to "train AI models to discover and design small molecules in a new way... placing AI's ideas at the center of its R&D process."

🚨 New TSV Investment: @Arda_Tx Harnessing data science to target chronic diseases, Arda is focused on eliminating disease-driving cells, not just modifying their behavior. Beginning with fibrosis, which contributes to 35% of global deaths, the potential is enormous. Read more about why we invested here: bit.ly/3Y59UDI

Enterprise AI adoption is at an all-time high, but so are the risks. Distributional's $19M Series A, which we're excited to have led, brings much-needed automated testing to AI systems! Read about why we think @dbnlAI can bridge the AI confidence gap here: bit.ly/4eSbHTg

TSV portfolio company @tryperdiem named one of @BusinessInsider 49 most promising fintechs! 🎉 Partner @dabelon said it best: If Starbucks were a bank, its deposits would surpass 90% of US FDIC institutions. With 30% of orders through its app, Starbucks uses digital tools to drive customer spend. Per Diem brings this model to SMBs with apps for payments, loyalty, and engagement. Congrats to all the startups on the list!

CALLING ALL AI INFRA BUILDERS! Join Two Sigma Ventures’ @dabelon & @vin_sachi as they dive into & debate the next 5 years of AI infrastructure with founders, academics, and operators: - @jefrankle, Chief AI Scientist @Databricks - @Zhou_Yu_AI, Professor @Columbia & Founder of ArticulateAI When? July 29th from 6:00 PM - 8:00 PM RSVP here: lu.ma/fa5a12an

TSV founder @csbeirne was live yesterday answering questions for @googlecloud #VCAMASeries! If you weren’t able to make it, here are a few highlights 👇

Have a question about TSV focus areas? What industries and technologies we're most excited about? How best to pitch us? Now's your chance to ask them. On Tuesday July 16th, TSV founder @csbeirne will be participating in the @googlecloud #VCAMASeriesSeries! Join him live alongside 300+ startups, and Ali Goldstein Norup as he shares insights on investing in the current VC market and Two Sigma Ventures ‘Must Watch’ list of industries. Snag your spot here: goo.gle/VCAMA-TwoSigmaVentur…

Results from our Summer Party

At our Summer Party, we asked our network to predict when certain technological advances would become a reality. Now we want to hear from you. Vote below and stay tuned to see how the results compare 👀

"When we think of family building, it's everyone's problem––both men and women." Read our blog post + watch Partner @DusanPerovic and co-founder/CEO @DinaRadenkovic discuss the demand for advanced IVF + egg freezing, and how @GametoGen is ushering both into the modern age below 👇

Thanks so much to everyone who came out to the TSV Annual Summer Party celebrating entrepreneurs, investors, and operators building at the edge of what’s possible… at @EdgeNYC ! & a special thanks to our incredible portfolio company @remote for partnering with us for the event! We’re already looking forward to the next one 🎉

📣Transforming women's health transforms society 📣 IVF is no longer just for treating female infertility - it's a vital solution for couples choosing to start families later, overcoming rising infertility rates across genders, and enabling diverse paths to parenthood. Today, we’re thrilled to announce that we’ve led @GametoGen's Series B to support their novel IVF approach which aims to make it far more accessible, convenient, and faster for anyone to start a family. Read more here: endpts.com/new-york-startup-…

Bringing a drug to market takes 10+ yrs, & only 1/10 make it. Thx @HealthcareBrew for giving @DusanPerovic the opportunity to dive into how AI is enabling faster delivery of more effective therapies with @JuliaChapin (@AbridgeHQ) @RobbieFreeman (@MountSinaiNYC) & @PatrickKulp.

Thank you to the wonderful crew in Pittsburgh that came out for our tech meetup!🎉

Had a great time hosting the @remote Global Table at our offices in NYC. Thank you to the speakers and co-hosts @marcelolebre @dabelon @bonatsos @GopinathRashmi @EasopHQ, and to everyone who joined!

This Monday, we teamed up with @StartupGrind NYC to host @paulajackler from Figure, who shared strategies for scaling high-growth startups. Thank you to all the founders and builders who joined us there!

Conversation highlights from our recent event on the state of enterprise-grade ML solutions, served up by @jefrankle (Chief Scientist, @MosaicML), @vjkaruna (Field CTO, @scale_AI), @apwenchel (CEO, @itsArthurAI), + Gideon Mendels (CEO, @Cometml) 👇 twosigmaventures.com/blog/ar…

Grateful for the opportunity to connect with so many smart founders at @CollisionHQ, where @villi joined investors from @Initialized and @FPVventures to share insight into the changing early-stage fundraising playbook. Thank you to everyone who joined us there!

That's a wrap. Thank you to everyone in our community who joined us for our annual summer party last night at a secret social club in Soho. Wouldn't be where we are today without you.

📍from our NYC mixer with @Founders_Forum. Thank you to @brenthoberman and @carolyndawson_ for hosting - and to the speakers @GaryMarcus @mkearnsupenn and @AnneSimondsReal!

We hosted a great group last night for a talk on building enterprise-grade ML solutions. Thank you to our speakers @vjkaruna, Gideon Mendels (@Cometml), @apwenchel, Jonathan Frankle (@MosaicML), Sara Wiltberger (Deepmind), Roza Chojnacka (Google), @alexnortn, Nina T. (@MIT)!

Marketplaces have radically transformed the way we shop, travel, & interact. Now, they’re being radically transformed by AI. @dabelon demonstrates how LLMs can level up marketplaces, from enabling efficiencies, to improving customer experience. twosigmaventures.com/blog/ar…

In the last 12–18 months, we have seen new entrants in the risk infrastructure space gain momentum. @kyradurko maps key players who are solving important challenges across identity verification, due diligence and insights, and transaction monitoring. 👇 twosigmaventures.com/blog/ar…

Meet the enterprise leaders who are steering AI’s impact. Join us and our friends at The Martin Trust Center for @MIT Entrepreneurship, in dialogue with experts from @DeepMind, @Google, @MosaicML, @Cometml, @scale_AI and @itsArthurAI. Get involved here: lu.ma/63v3y0jt

Friends in NY - join us, @TeamSupermomos, and the AI community for generative AI lightning talks at our Soho HQ, featuring perspectives from @Google's Roza Chojnacka and Pai Zhu. Register here: lnkd.in/djeS8ksU

With @anomalo_hq, Founder & CTO @jeremystan wants to help businesses build with confidence and trust in their data, through a scalable, modern solution to data quality that spots issues before customers do. Learn how here ⬇️ twosigmaventures.com/blog/ar…

For the IPO Summit at the @NYSE, @csbeirne contributed to a timely dialogue with friends from @GunderIPO and @ThriveCapital about the "gift of time" provided by the current market. Thank you NYSE for helping growth stage founders ready themselves for when the market rebounds 🚀

How will personalization transform content creation? In our new story, @text_blaze Co-Founder & CEO, Dan B., shares his take on how businesses can leverage AI for greater relevance ⬇️ twosigmaventures.com/blog/ar…

@kasistoinc, specializing in conversational AI products that humanize the digital banking experience, has been using Large Language Models since 2018. In our recent story, CEO & Co-Founder Zor Gorelov speaks to how Gen AI will fuel innovation in finance: twosigmaventures.com/blog/ar…

Coast to coast! Founder dinner in SF with the @TwoSigmaVC community.

@DaphneKoller, CEO & Founder of @insitro, sat down with @DusanPerovic of @TwoSigmaVC at @StartupGrind to talk about what AI/ML Advancements Mean for Startups. "Data is the ultimate competitive advantage & enabler of real innovation. This inspired the formation of insitro."

📍Onstage at Startup Grind Global 2023: “What does it look like to build on language as a protocol?” @TwoSigmaVC GP @schwiepit, @insightpartners MD George Matthew & @CalibrateVC Co-Founder Kevin Dunlap break down the future of AI investing. Congrats to the @StartupGrind team 🎉

Congrats to @DaphneKoller and the team at @insitro for making the @Forbes AI 50, recognizing the most promising privately-held companies building businesses out of artificial intelligence ⚡️ forbes.com/lists/ai50/?sh=4b…

The team at Osmo is transforming the fragrance industry using gen AI, evaluating billions of novel aroma ingredients in seconds, & designing them to precise specs of quality & safety. Here, CEO Alex Wiltschko shares what's next for these tools to take off: twosigmaventures.com/blog/ar…

Friends at @StartupGrind Global in SF - join us for a fireside chat between @DusanPerovic & @DaphneKoller, Founder & CEO of @insitro, cofounder of Coursera, & recipient of a MacArthur “genius grant.” We'll unpack all things AI/ML and how founders can harness these innovations.