Bringing together data, biology, and intelligence to reveal insights hidden within complex chronic disease.

Menlo Park, CA
No need to leave your bed! We’ll bring the research to you. Mobile sample collection is our next chapter in expanding access to research on complex chronic conditions. Every participant receives a research report back. Sign Up: chroniclebio.com/biobank
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Welcome to the #ChronicleBiobank, @sam_heds! 🩸 + 🧪 = 🫶
Such a meaningful experience at the @chroniclebioai lab, seeing the biobank behind the research! Every sample in these freezers represents a person, living with these complex chronic illnesses, that needs answers. Thank you @SummerDashe & team for the warm welcome!
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Your illness isn't waiting on a test to be real. The test is waiting on science to catch up. It's why I'm proud to be a part of the work at @ChronicleBioAI and fighting to find the answers for people who've been told for far too long their experience is "normal".
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Made it! Welcome to the Chronicle Biobank, #innovationinn participants!
We have shipped #innovationinn samples from Canada to @ChronicleBioAI There was a delayed in customs that had us at the edge of our seat, but they made it safely. Thanks @rohit0logy and team for staying on top of it with us
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When the team at @RenegadeRes reached out to us to collaborate on sample analysis, we didn't hesitate. In under 24 hours we had a plan in motion, kits shipped their way, and vendors prepped. The Renegade team worked just as quickly to make it happen. Patient-led science means we all understand what's at stake with our work and why time matters. Millions of people are losing days to their symptoms. We are working rapidly to understand the biology of complex chronic conditions in an effort to find treatments that could help. ChronicleBio is generating multi-omic data on samples collected during Renegade Research's Innovation Inn. It was a multi-day event where #MECFS patient-researchers deliberately tracked their own post-exertional malaise (PEM) to help characterize what happens in the body before, during, and after. Across the event, the team collected 482 plasma, serum, and whole blood samples at multiple timepoints, alongside HRV, lactate, heart rate, blood pressure, and symptom data. We supplied collection kits for every timepoint, and our analyses will complement everything else being measured. We're proud to be one of several partners contributing to this work, alongside @amaticahealth, Alden Scientific, Arden Bio, Infinity Bio, CDI Labs, Theriome, @imyoohealth, and an MIT team from @ImmunoFever’s MAESTRO project demoing nailfold capillaroscopy, WAVi EEG, and Right Eye tracking.
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One of the ways our researchers determine what could be causing fatigue in complex chronic conditions is through metabolomics. In our study, we measure 2,000+ metabolites that can give participants insights on their biology. More Info: chroniclebio.com/biobank
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Welcome to the Chronicle Biobank! 🩸 + 🧪 = 🫶
Just got my blood drawn for multiomics from @ChronicleBioAI ! This futuristic company is using long-read genome sequencing (from @nanopore ), transcriptomics, proteomics, and metabolomics to build an AI foundation model for rare and complex diseases, like #EhlersDanlosSyndrome and #POTS. I just want to thank the team and give a shoutout to @fidjissimo for putting this together. Fidji is one of the most amazing visionary leaders in the entire tech space. Motivated by her own health struggles, put together a new company doing what I have been dreaming someone would do since my hackathon in 2019. It’s cool to be working with all star research scientists like @CortDoesScience as well. Interestingly, all of this became possible because I met @gdb / Greg Brockman, president and cofounder of OpenAI, at an EDS conference at GitHub, hosted by the nonprofit I work with, @Research2People . Greg pleasantly surprised everyone and showed up unannounced with his wife, who has EDS like me. After talking with them for a while, I was introduced to Fidji by email. Fidji introduced me to her people, who I got to know and respect, and now I am proudly working with ChronicleBio to do what I have been dreaming of ever since starting with Research to the People, where my multiomics journey began and changed my life. This now is the next level - far more ambitious than anything before. I have to say, ChronicleBio is doing the most cutting edge data generation in the entire space, and I am so happy to be a part of this. Thank you ChronicleBio! Today is a good day! #EDS #EhlersDanlos #MECFS #MCAS #RareDisease
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ChronicleBio retweeted
I disagree with Dario on most things, but this is spot on: “At this point, saying that AI will cure cancer is more a cliché than it is inspiring, and most people think it is deceptive. The thing that will work is actually curing cancer.” The thing that frustrates me is that some people often draw a straight line from smarter models → cures, without acknowledging how much infrastructure is missing in between. We’ve still got a lot of work to do, people. The regulatory bottleneck gets a lot of attention. But the bigger bottleneck may be that in many places, we’re lacking the right biological data. AI can’t reason its way to cures if we haven’t generated the data required to understand the disease in the first place. Ironically, that’s why I’m most bullish on AI making dramatic progress in cancer first: decades of investment have produced extraordinary datasets across genomics, pathology, imaging, clinical outcomes, and more. For complex chronic diseases, much of that infrastructure simply doesn’t exist yet. The good news is that many companies (including @ChronicleBioAI) are racing to build it. But model intelligence and biological infrastructure are going to have to scale together. I really do believe AI can cure all diseases but only if we build the infrastructure to translate intelligence into cures at the same pace that models improve (which is a high bar!). Otherwise, we risk having superintelligent AI with an incomplete picture of human biology, and delay that promise by years.
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Ever wonder what actually happens to your sample after it’s collected for the Chronicle Biobank? Most study participants never hear what researchers found. We invite you into the scientific process while it’s unfolding. Learn More: ChronicleBio.com/biobank
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ChronicleBio retweeted
Chronic Illness @ChronicleBioAI : US adults 18+ can join a longitudinal mobile collection study with up to 3 blood draws and multi-omics research reports. The initial collection is free for the first 250 participants; later cohorts pay $400/collection. connect.chroniclebio.com/sig…
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Heads up to ME/CFS researchers: Our @RenegadeRes team just collected 482 plasma, serum, and whole blood samples before, during, and after PEM. The majority are being set aside for specific companies to analyze, like @amaticahealth, @ChronicleBioAI, @AldenScientific, @infinitybioinc, @cdi_labs, and Theriome, but we saved some extra in case we come across additional testing. We also collected a ton of other data, like HRV, symptoms, lactate, HR, BP, etc. @immunofever's team from MIT was also there demoing nailfold capillaroscopy, WAVi EEG, and Right Eye. We want to get as many eyes as possible on our data and have as much analysis as possible done on our samples, so please reach out if you're interested in helping. #InnovationInn
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Thank you for sharing, Amy! It may take a few weeks for those who are transferring accounts to see their historic data appear. App versions coming soon.
Replying to @ChronicleBioAI
If you've used Chronicle Bio before, you may need to transfer your old account to login. If no code appears in your inbox to reset the password, follow the link and instructions on the reset page. I look forward to giving samples to contribute to your study! Glad to have an at-home blood draw option.
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Mobile sample collection is here! Join the Chronicle Biobank Study from home. Get individual research reports back. Spots are limited. The initial collection is free for the first 250 participants. Sign Up: chroniclebio.com/biobank #Chronicling #ChronicIllness #Research
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I was so proud of our team yesterday and grateful for everyone supporting us. Our team had 3 time-critical issues hit us at the same time. ALL of the samples we had collected over 2 days were in danger. Everyone stayed calm and focused and jumped into action. Thanks to @dibidave and @imyoohealth for being on top of things, watching the tracking for the package we were supposed to get out that day with overnight shipping. We thought it went out that morning, but it was still sitting on the counter when I noticed their messages at like 6pm. I dropped it off with 5 minutes to spare. Thanks to @Drewhywhywhy's doctor for getting us space in his hospital's -80 freezer for 180 samples from the first two days. Thanks to Alain Moreau and his team for getting us dry ice and space in one of his -80 freezers. Thanks to @rohit0logy for hopping on a call with us to tell us how to process the samples for @ChronicleBioAI. #InnovationInn
1/Yesterday we had a huge scare. Our -80 freezer broke. I (@IsabelRamirezRD ) think that’s why my PEM was worse. Our host Marie and @doc4care sprung to action and drove the specimens to a doctor friend of hers at his hospital
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In our first year, we reached patients in Texas, Utah, Arizona, and India through our clinic partnerships and the Chronicle I Study. The overwhelming response has proven patients want to be part of the solution. They just have to have a way into the equation. 🩸+🧪=🫶
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At ChronicleBio, we've been thinking about this since day one. Expanding access to research is vital to its success and those it serves.
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Mobile sample collection is coming soon. Head to chroniclebio.com/participant… and sign up for our email list to get notified. The Next Chapter Begins 08/11/2026.
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ChronicleBio retweeted
"You know, when I was at OpenAI, I said I think if AI accomplishes everything but doesn’t cure disease, that would be a very sad state of affairs." In Fidji's first interview since leaving OpenAI, she tells me about her company ChronicleBio. 🧵 fortune.com/2026/08/03/fidji…
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