Finally online - sharing our findings that #Lyme disease bacteria can live in female reproductive organs for over a year and increase risk for gynecological disease!!! We found this increased risk in mice and humans! 😱 (thread below) medrxiv.org/content/10.1101/…

Excited to share our new review in @JExpMed where we explore how the vagus nerve acts as a two-way communication highway between the nervous and immune systems. We cover how vagal sensory neurons encode cytokines, how different efferent pathways control immunity, and what's next for bioelectronic medicine now that VNS is FDA-approved for RA. Vagal neuroimmune circuits will be key to developing the next generation of biomarkers and therapies to treat and control inflammation!

🚨🚨🚨 Adding 850 nm near-infrared light to indoor LED lighting significantly reduces blood glucose levels by improving mitochondrial function. A new preprint by Glen Jeffery and colleagues found, using oral glucose tolerance tests AND continuous glucose monitors, "subjects exposed to standard LEDs had significantly increased blood sugars, while those exposed to lamps with added 850nm had significantly reduced blood sugars. These real-world data highlight the importance of light in controlling metabolism." (@glen_jeffe5111 @KMeihami) @RogerSeheult @hubermanlab @AbudBakri @KenDBerryMD @seagertp @BlueLightDiet @zaidkdahhaj @rowanjacobsen @ChrisMasterjohn

Scientists from Stanford and UCLA just found a hidden "off switch" for heart scarring. When the heart is stressed, the cells that cause dangerous scar tissue (fibrosis) get switched on by three chemical sensors working together. Blocking all three at once — but not just one — stopped the scarring in human heart tissue and in mice. This could become a new type of heart failure drug. science.org/doi/10.1126/scie…

Congrats to Dr. Luke Brown on his PhD discoveries @sarah_h_ross @aaas @ScienceMagazine @NSERC_CRSNG @CIHR_IRSC @Luke_Brown_91 Visualizing a lung neutrophil-platelet immunothrombosis cascade during sepsis in mice | Science science.org/doi/10.1126/scie…

Watch each talk from this year's Community Symposium, in our youtube playlist now! #MECFS26 piped.video/playlist?list=PL…

COMT clears dopamine, norepinephrine, and some estrogen metabolites. The common Val158Met variant changes the amount of available enzyme. Slow COMT can mean better working memory and more stress sensitivity. Fast COMT often flips that, and it is sometimes called the warrior gene (dumb name). Slow COMT + a sudden influx of methyl donors (e.g. methylfolate, methyl-B12, SAMe, TMG) can feel like mood whiplash - irritability, anxiety, irrational anger. Quercetin/luteolin can inhibit COMT. Check your genes to know (or ask your spouse AITA...) geneticlifehacks.com/comt-ge…

‘Patients experiencing autonomic storms related to dysautonomia may present with abnormal movements, including convulsions, tremors, and myoclonus.’ Misdiagnosed with FND. Had orthostatic intolerance. Treatment with OH / POTS meds helped 10/17.

Beautiful new paper from the @GioeleLaManno lab 🧠 The team discovered 539 lipidome-defined brain clusters ‘lipizones’, territories that can be linked to functional anatomy and cell types. Full paper + interactive website ✨: > nature.com/articles/s41586-0… > lbae-v2.epfl.ch/

Excited to share our new paper, out today in @ScienceMagazine! We developed senescence-modulating nanoparticles (SMNPs) that target P-selectin+ pathogenic senescent-like macrophages in fibrotic tissues and tumors. science.org/doi/10.1126/scie…

📍Together, this work suggests that cerebrovascular damage is not simply a downstream effect of Alzheimer’s, but an APOE4-driven process actively contributing to disease progression – highlighting the brain vasculature as an important, underexplored target for future therapies.

Blocking TGF-β signaling in APOE4 miBrains restored pericyte coverage and reduced myofibroblasts, vascular fibrosis, and amyloid accumulation. We also replicated these findings in aged APOE4 mice, showing that this vascular pathology can be reversed in our models.

Blood vessels in the brain deteriorate in Alzheimer’s, especially in APOE4 carriers. But what drives this damage? Our new study, out now in @CellPressNews , uncovers a mechanism linking APOE4 to vascular fibrosis and amyloid accumulation in the brain. 🧠🧬

Now that's an interesting topic and there is also the situation of acquired hEDS, where post-infection symptoms can include hEDS per studies by @ImmunoFever

New release: open-source GPT-2 model built from scratch in base R. Compact, inspectable code you can train on a laptop in under 3 hours with one command. No Python, deep-learning frameworks or external packages. github.com/switzerlandomics/…

Excited to share Minerva, our approach using genome language models for biological discovery! Using Minerva, we find that UG27 reverse transcriptase systems encode variable arrays of diverse ncRNAs with a shared structure, each templating a short DNA hairpin. With @garykbrixi.

Come join our phenomenal division! The Stanford University, Division of Infectious Diseases has opened a faculty search for physician-scientists and scientists in infectious diseases. Please see the advertisement below for details. facultypositions.stanford.ed…

Chronic Fatigue Syndrome: Influence of Histamine, Hormones and Electrolytes (1993) sci-hub.fr/10.1016/0306-9877… This paper is interesting on multiple levels 🧵

PANS/PANDAS mechanism just published: (They studied strep but it's not limited to strep, I've seen many cases from bartonella) Strep → IL-17A → microglia → leaky blood-brain barrier → sudden personality changes, OCD, tics, & many more. For 20 years parents were told it was psychosocial. It was inflammation due to an infection. It always was.

🏆 Here is a beautiful study of 17 patients who presented to the ER with abnormal movements and other neurologic problems and were misdiagnosed with #FND. It turned out that... all 17 patients had #dysautonomia and most improved with dysautonomia-targeted treatment! 🎉 The authors conclude that patients presenting with abnormal movements should be evaluate for dysautonomia and not be mislabeled with FND. P.S. I was not involved in this study or its publication, I promise, but my experience directly parallels that of the authors'. 😂 frontiersin.org/journals/neu…