RT @moderna_tx: mRNA-4157/V940 is an investigational personalized #cancer #vaccine consisting of a single #mRNA coding for up to 34 neoanti…

New🔥 #DataScience #Bioinformatics resource: 850,000‼️ #scRNAseq cells from 226 samples across 10 cancer types draw a map of the tumor microenvironment, in particular fibroblasts. Let’s see👇what are the main contributions of this work & what this means for #cancer #Genomics🧵

It’s spatial profiling day on @biorxivpreprint! Now @10xGenomics out with a preprint on integrated single cell, spatial and in situ analysis of FFPE tissue. Very excited by the extension of these high dimensional technologies to archival samples! biorxiv.org/content/10.1101/…

Presenting Slide-TCR-seq: our method for measuring the transcriptomes of cells & T cell receptor (TCR) sequences in situ! This collaboration w/ Bryan Iorgulescu, Shuqiang Li, Catherine Wu, and @insitubiology led to some cool findings... cell.com/immunity/fulltext/S… 1/8

Cancer #immunotherapy #DataScience resource of the week: #scRNAseq & #scTCRseq atlas of 400,000‼️T cells from 316 patients of 21 cancer types, derived from tumors, adjacent normal tissue, and peripheral blood.Half of data newly sequenced, half gathered from literature. 🧵(1/4)

The most recent paper from the lab has been published at @jitcancer. We employed single-cell mass cytometry to delineate tumor-associated and systemic immune profiles in #PancreaticCancer. jitc.bmj.com/content/10/7/e0…

Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis dlvr.it/STHB7s

“This grant proposal describes breeding experiments in peas. This reviewer remains unconvinced about the translational benefits. Applicant should switch to a more economically important crop like wheat. Applicant’s productivity also an issue, no paper published in last 8 years”.

ICYMI @TheVinodLab @MSKCancerCenter recent adjuvant trial of an mRNA #vaccine in patients with #PancreaticCancer (a collaboration with @BioNTech_Group) was featured on @cnn (@drsanjaygupta).

Here's a neat tech, where they capture T cells based on adherence to target tumour cells in a microfluidic device: doi.org/10.1002/adhm.2022001… A fast assay that addresses a lot of problems from say sticky multimers, and twiddling the pressure lets you sort out high avidity binders.

Minimize the chances of missing a T cell population critical to your therapy success!💪🏼 OS-T enables #TCR #sequencing of up to #1M #cells per sample at cellular resolution. Submit your #abstract and opt-in to an opportunity to be awarded 4 free samples! omniscope.ai/abstract-submis…

So lucky to have been able to work with @efaithd an incredibly talented, creative and overall amazing scientist! I have no doubt you will continue to do incredible work. Congratulations!

How do different routes of #mRNA vaccination (made by @Tibabiotech) impact the differentiation and distribution of #vaccine elicited CD8 and CD4 T cell memory responses in mice? @TwiterlessBuck @Masopust_Vezys @niaidcivics 👇🏼 biorxiv.org/content/10.1101/…

Our immune system follows circadian rhythm. A new review @SciImmunology. And why getting Covid vaccines in the morning elicits a better antibody and cellular immune response science.org/doi/10.1126/scii… @ScheiermannLab

I earned my PhD yesterday! In person too! What a surreal feeling all around. Wildly thankful for my incredible mentors on this journey, @FertigLab @NeehaZaidi @DrLizJaffee and everyone who made this possible.

It's a @NEJM case report, but a groundbreaking one. For a woman with refractory pancreatic cancer, genetically engineered T cells directed towards the KRAS driver mutation achieved substantial tumor regression nejm.org/doi/full/10.1056/NE…

Our new review ‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses” is out ⁦@NatImmunol⁩. Great team effort with Dietmar Zehn ⁦@LabOxenius⁩ Robert Thimme ⁦@teximmed2⁩ and Gustavo Almeida nature.com/articles/s41590-0…

Head-to-head comparison of immune response, both antibody and cellular, for 4 vaccines: Moderna, Pfizer, Novavax and J&J cell.com/cell/fulltext/S0092… @CellCellPress @profshanecrotty @ljiresearch @zhang_zeli @jmateust @camilahcoelho @SetteLab