Nature research paper: A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion go.nature.com/4r3Zwdv

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Cancer-derived SERPINE1 and SERPINB2 are local spatial organizers of immune suppression @Nature @IcahnMountSinai @ChiaraFalcomata @SinaiImmunol nature.com/articles/s41586-0…

How do dendritic cells control tertiary lymphoid structures in cancer? Raphaël Mattiuz and @jboumelha just showed us how–just out in @ScienceMagazine. Happy I could contribute to this important piece. @MiriamMerad science.org/doi/10.1126/scie…

Excited to share our new study @ScienceMagazine by the fantastic Raphael Mattiuz and @jboumelha @SinaiImmunol showing how DC build and sustain tertiary lymphoid structures in cancer. A major step toward enhancing anti-tumor immunity (1/2) science.org/doi/10.1126/scie…

Congrats Flo 🎉 So exciting for the science that will come out of your lab!!

hello world. Excited to launch the Ingelfinger Lab account! We’re a young lab in Germany’s Black Forest tackling key questions in immunology with innovative single-cell technologies. Follow us for updates on systems immunology, machine learning & translational oncology. fi

Excited to share our new study out in @SciImmunology We show that Monocyte-derived Macrophages drive oxidative damage during neuroinflammation science.org/doi/10.1126/scii…

#ScienceSaturday ❓ Why do some cancers resist immunotherapy? ➡️ A recent study in Nature found that certain cancers can “trick” the body’s immune system. They do this by changing how cells in the bone marrow develop. These changes cause more immune cells called macrophages to form — but these macrophages actually block the immune system from attacking the tumor. ➡️ Lung cancers cause this change by stressing cells in a way that activates a protein called NRF2. This reprogramming creates macrophages that protect the tumor instead of fighting it. ➡️ The researchers found that blocking NRF2, through drugs or genetic changes, lowered these protective macrophages, boosted immune cell activity and made immunotherapy work better. This suggests a new way to improve treatments for cancers that usually resist immunotherapy. 🌟 Congratulations to senior author Miriam Merad of the Icahn School of Medicine at Mount Sinai, and collaborators at Institut Gustave Roussy, Harvard Medical School and others for advancing this critical work. @MiriamMerad @SinaiImmunol @IcahnMountSinai

Big congrats, Flo! Fantastic new tool to analyze high-dimensional flow data. @FlorianIngelfi1 @IdoAmitLab @YosefLab

Thrilled our Perspective in @NatureAging is out! With @MatthewD_Park et al., we spotlight how aging reshapes RTMs and skews myelopoiesis–with consequences for healthy aging and cancer @MiriamMerad

New preprint out! 🚀Spearheaded by @ChiaraFalcomata we could show how pancreatic cancer cells evade the immune system by modulating their TME with the extracellular factors Serpine1 (PAI-1) and Serpinb2 (PAI-2)! #PertrubMap #PDAC

So excited to share our new paper out in @Nature led by the fabulous @AnaisElewaut and @guillemxtivill providing mechanistic insights into anti-tumor immunity and why it may fail in so many patients! Sky-torial on @obenaufa.bsky.social rdcu.be/d1F7s

Another @preprintclub Journal Club by Zi Yan Chen & @nkg2d1 @ImmunologyUofT discusses @biorxivpreprint by @VillarVesga et al. @BecherLab @SarahMundt5 showing that monocyte-derived cells in CNS produce mitochondrial ROS to promote neuroinflammation bit.ly/495E7HP

As science twitter is moving to where the sky is blue: bsky.app/profile/mmschaefer.…

Fantastic @SinaiImmunol retreat on neuroimmunology–neuron-immune/immune–neuron interactions #CGRP #TRPV1 Thanks for organizing @itchdoctor @michel_enamorad @MiriamMerad

Macrophages do a whole lot more. They are a major subunit of basically all tissues. They protect the brain from damage, regulate thermogenesis in adipose tissue, and are electrically coupled to cardiomyocytes in the heart. They are the immune system's ultimate Swiss Army knife!