This project was only possible because of the expertise of many amazing scientists. A big thank you @shsternberg, @IsraelF96135088, @minjookies, Leslie, @JingWang0610, @Vopinator, @tehhoyen, @jerrintgeorge, @jason_mohabir, @AcreeChris! I could not wish for a better team! 10/10

The pore’s dimensions seemed ideal to accommodate dsDNA. @minjookies mastered the purification DNA-bound TnsC, for which @IsraelF96135088 refined not one but two DNA-bound structures. The overall heptameric structures of DNA-free and DNA-bound TnsC are very similar. But… 7/10

Given its important role in target site selection, @minjookies purified the challenging TnsC and the amazing @IsraelF96135088 (make sure to check out his thread) built the beautiful cryoEM structures of heptameric TnsC ring complexes. TnsC oligomerization is ATP-dependent. 6/10

Excited that our paper is now online @Nature! Selective TnsC recruitment enhances the fidelity of RNA-guided transposition - the result of a fantastic collaboration of the @shsternberg and @IsraelF96135088 labs. (nature.com/articles/s41586-0…) A thread: 1/10

Researchers report that the red pigment pelargonidin, derived from strawberries, acts as an intestinal permeability enhancer, potentially enabling medications such as #insulin to be delivered orally rather than by injection. In PNAS: ow.ly/c3aK50Km5t1

Just brilliant! 🤩

classic.

Using #CRISPR gene editing and a new pipeline for T cell receptor discovery, scientists have engineered new T cells for adoptive #CellTherapy that can rapidly eliminate leukemias in culture and in mice without off-target effects. fcld.ly/uig24dv @ScienceTM

Our March issue is live! The cover story is @Zhu_Lab's in vivo #CRISPR screen that ID's chromatin regulators as druggable targets for liver regeneration.The image depicts characters who represent ribosomes repairing a damaged liver with the help of BAZ2i. cell.com/cell-stem-cell/curr…

Using #CRISPR gene editing and a new pipeline for T cell receptor discovery, scientists have engineered new T cells for adoptive #CellTherapy that can rapidly eliminate leukemias in culture and in mice without off-target effects. fcld.ly/uig24dv @ScienceTM

I made this figure out of my fascination with protein architectures. I call it "Molecular Machinery of Life." Thought to share it with you to enjoy your eyes. Can you detect, by heart, the Nobel Prize-Winning structures? @AcademicChatter #AcademicTwitter

A recent Science study analyzed thousands of connections between potential disease-associated mutations, specific proteins, and medical conditions, thereby providing a detailed map for use by future researchers. fcld.ly/jk3x6of #NationalProteinDay

But there is hope! My first grant after cloning PIEZOs was triaged. But @NIH did ultimately fund the work that showed PIEZO2 is the principal mechanosensor for touch and proprioception. Message: stay positive, don't doubt yourself, and keep trying. 3/3

Wade Van Horn's paper "Evidence that the TRPV1 S1-S4 membrane domain contributes to thermosensing" was featured in Nature’s roundup of yesterday’s Nobel prize! nature.com/collections/dbaja… @ASUResearch @asunews @NatureComms