Physician-scientist at @CRI_UTSW with a focus on #LiverCancer and organ regeneration.
Dallas, TX
- Tweets 3,361
- Following 652
- Followers 2,933
- Likes 12,051
Pinned Tweet
Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: authors.elsevier.com/a/1gua9… 1/10
37
182
657
193,920
Hao Zhu Lab retweeted
What gives some colorectal cancer cells the ability to metastasize? In our new paper, we find that tumor-intrinsic ceramide synthesis is a metabolic switch for metastatic initiation. 🧵 Free access: science.org/eprint/UAMCP9BAE…
18
29
131
12,620
Hao Zhu Lab retweeted
You don't want to miss the first virtual event for the Summer Liver Academy Meeting (SLAM) Community! Join us on October 15 for a fantastic talk from Dr. Zhenghui Jiang bit.ly/3V6iIet
#SLAM #LiverResearch #MASLD #ALD #Hepatology @harvardmed
2
1
330
Hao Zhu Lab retweeted
New from Heidelberg University 🚨
In healthy liver, CYP2E1 expression is predominantly localized to zone 3 hepatocytes. In chronic alcohol-related liver disease, CYP2E1 expression reflects pericentral hepatocyte integrity rather than ethanol responsiveness, emphasizing the need for cell-type validation in liver disease studies.
Read the study: bit.ly/46D90D7
#Hepatology #LiverDisease #Epigenetics
2
5
329
Hao Zhu Lab retweeted
So excited to be part of this incredible work out today in @ScienceMagazine on how P-selectin-targeted anti-senescence nanotherapy can fight fibrotic conditions and cancers. Congrats to @LoweLabMSKCC and @hellerlab members and others @MSKCancerCenter!! science.org/doi/10.1126/scie…
4
16
135
7,032
Hao Zhu Lab retweeted
We are recruiting new faculty at all levels who seek to solve fundamental problems in biology and disease. @CRI_UTSW is an exceptional and highly collaborative environment to build a research program and pursue ambitious science. Join us!
Come be part of our #relentlessdiscovery and discover the treatments of tomorrow. Faculty recruitment through Oct. 15 👉 cri.utsw.edu/careers
16
30
4,554
Hao Zhu Lab retweeted
Timely, @Thelancet on GRAIL today!
"To date, there is no evidence that any multicancer detection testing prevents cancer, consistently detects it at an earlier stage, or reduces cancer-associated mortality. Meanwhile, false-positive rates have been predictably high. The costs associated with evaluating false-positive results are very real, as are the psychological burdens borne by patients who are incorrectly told they have cancer—or incorrectly reassured that they do not."
thelancet.com/journals/lance…
In its pivotal clinical trial, the GRAIL test to detect early cancer failed its primary endpoint. It detected only 3 early cases per 1,000 people assessed. There were more false negative results (N=196) than true positives (N=133). Reviewed here erictopol.substack.com/p/the…
But you wouldn't know any of that if you read today's WSJ editorial!
gift link
wsj.com/opinion/a-grail-canc…
28
99
380
64,860
Hao Zhu Lab retweeted
Breaking News: Federal officials are drafting an executive order that would help cement President Trump’s ability to control billions of dollars in scientific grants funded by the National Institutes of Health. nyti.ms/4yhi6RS
682
1,519
2,574
2,229,985
Hao Zhu Lab retweeted
Partnerships extend the reach of our #SomaticGenomics platform to explore complex biology across therapeutic areas. Hear from our CEO, Rahul Kakkar, MD, on how partnerships can drive the discovery of potentially breakthrough novel medicines.
Learn more: quotient-tx.com/partners
1
3
164
Ever wonder how heterogeneity defines bladder cancer subtypes?
Ha and Hsieh Lab postdoctoral fellows @pushpa_itagi and Samantha Schuster @fredhutch did, leading to a deep study of bladder cancer clonality, evolution, and heterogeneity published @Nature
nature.com/articles/s41586-0…
13
58
167
36,894
Hao Zhu Lab retweeted
Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv
nature.com/articles/s42255-0…
10
88
310
20,455
Hao Zhu Lab retweeted
Every so often, a major event happens in your life to validate years of work. SRRK’s ISEMBYLD was FDA approved. Having participated in its development from basic science to approval, as a physician-scientist, this is one of my best days. Happy for ISEMBYLD to help SMA patients.
23
33
224
15,999
Hao Zhu Lab retweeted
Prior to cancer immunotherapy, vaccination of any kind, not only vs Covid, is associated with a small and transient (~6 months) benefit of improved survival nature.com/articles/s41591-0…
6
51
212
30,423
Hao Zhu Lab retweeted
1/ T cell immunotherapies are thought to require tumor-specific T cells. Very excited to share our work showing how T cells can eliminate tumors without tumor specificity via paracrine signaling. 🧵
nature.com/articles/s41590-0…
11
39
178
14,952
Hao Zhu Lab retweeted
Yesterday was a glorious day of science @nyugrossman @nyulangone with two fantastic papers
1st by @giladevrony on impact of caloric restriction on mutation rates:
cell.com/cell/fulltext/S0092…
2nd by @MarcusDGon @eze_dantas on refined starches & immune markers
cell.com/cell-press-blue/ful…
4
31
104
6,716
Hao Zhu Lab retweeted
How did we come to understand cancer in the light of evolutionary theory?
Nothing makes sense if not with population genetics!
In our latest @NatureRevCancer review we unpack how population genetics theory applied to somatic cells allows us to measure and predict cancer evolution from molecular data.
Computational modelling in oncology has gone a long way but we need to go much further.
The frontier is combining evolutionary theory with machine learning.
Link below👇
4
52
188
9,958
Hao Zhu Lab retweeted
Check out this absolutely beautiful paper by Mathieu Deygas together with Pablo Vargas and Matthieu Piel. Stunning images and findings!
Neutrophils remodel their actin cytoskeleton rapidly as they navigate narrow capillaries of varying sizes, enabling them to squeeze through without causing blockages.
Learn more in @SciImmunology: scim.ag/4ibeax0
1
8
895
Hao Zhu Lab retweeted
Very excited to share our new paper, published in Cell!
We found that caloric restriction (CR) in mice reduces somatic mutation burdens across the genome, and that this effect has some surprising features.
🧵👇
1/8
12
65
281
26,421
Drs. Yanagisawa and Mignot received the 2026 Albert Lasker Award for Basic Medical Research for their pivotal work in the discovery of the orexin (hypocretin) system and its role in narcolepsy.
Learn more in the Clinical Implications of Basic Research article “The Legacy of Orexin (Hypocretin) Research in Narcolepsy and Beyond” by Sebastiaan Overeem, MD, PhD, and Birgitte R. Kornum, PhD: nej.md/4A71sWP
ALT An illustrated diagram from the Clinical Implications of Basic Research article "The Legacy of Orexin (Hypocretin) Research in Narcolepsy and Beyond." Panel A shows the orexin system, discovered in 1998, which consists of two neuropeptides produced in the lateral hypothalamus and two G-protein–coupled receptors expressed in most areas of the brain. Panel B shows deficiency of orexin signaling leading to narcolepsy symptoms in both dogs and rodents. Panel C shows that human patients with narcolepsy lack orexin peptides in the cerebrospinal fluid (CSF), which has led to a reliable diagnostic test. Panel D shows therapeutics from 2014 to the Present.
1
121
331
35,459
Hao Zhu Lab retweeted
Excited to share our review @NatureRevCancer! We cover all that we, as a field, learned from our efforts to understand genotype to phenotype interactions in cancer and somatic evolution. We also cover what future measurement technologies can take us in this domain.
PDF link 👇
2
64
247
12,145