Physician-Scientist tinyurl.com/s98xg3u Discovered p21(WAF1), TRAIL DR5, TIC10/ONC201; 1st ever FDA approval for H3K27M-glioma IU Physician-MBA Class '28

Pennsylvania
Books I have edited that may be of interest to those who study cancer. They are all available on Amazon.
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Our bodies create ~330 billion new cells every day through cell division. #HHMIInvestigator Andy Moore at our Janelia Research Campus captured that process in stunning detail — a feat that earned him 4th in the '26 @NikonSmallWorld in Motion Competition: bit.ly/4yT5d0k
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Professor and Dean of the Indiana University Richard M. Fairbanks School of Public Health Dr. Nir Menachemi is an amazingly gifted masterful teacher and facilitator with a wealth of knowledge of healthcare in America, policy, and business. A privilege to learn from him at the @KelleyBizMed IU Kelley School of Business Physician MBA Program.
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
Today, the FDA approved a treatment for advanced renal cell carcinoma. fda.gov/drugs/resources-info…
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
Sometimes the most caring answer is no. Dr. Michelle Kittleson (@MKIttlesonMD) explains why in a new NEJM Voices blog post. Read the post and sign up for email alerts: nej.md/47bwkI6
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
Physicians, scientists & activists (including myself) sent an open letter to @SecKennedy & @realDonaldTrump raising a series of objections, including the continued vaccination of children and the FDA-identified deaths.
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
💥BREAKING: CDC recommends off-label Covid vaccines for healthy babies, children and young adults The decision comes despite the FDA restricting vaccine approvals in people under 65 to higher-risk groups, and despite federal scientists linking child deaths to the shots. LINK👇👇 @SecKennedy @MaryBowdenMD @unhealthytruth @newstart_2024 @DowdEdward @P_McCulloughMD @brownstoneinst @MarioNawfal
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It was great to meet Dr. Matthew Smith-Cohn, a fellow physician MBA classmate at the @KelleyBizMed IU Kelley School of Business Physician MBA Program yesterday during lunch and see from his perspective the importance of research as an engine for discovery to help patients. As a neuro-oncologist and one who trained in the same oncology fellowship program I trained in at Hopkins, he is using dordaviprone to treat patients with H3K27M-mutated glioma. It is the honor of a lifetime for me to hear that a drug, ONC201/TIC10 screened in my lab and discovered in 2007 is FDA-approved and used to treat patients. We need to do more to find cures for these horrible brain tumors that affect children and adults in the prime of their life.
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Powerful speech.
WATCH: Prime Minister Benjamin Netanyahu's Speech at the United Nations General Assembly. 🇮🇱
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
News: @FDA approved a new long-acting insulin taken once a week for adults with type 2 diabetes to help manage their blood sugar along with diet and exercise. fda.gov/drugs/news-events-hu…
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
540 patients . The thing that matters for OS is the degree of biomarker matching
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
I don’t think I am- I’m simply explaining to you what I am doing since you claim something about my beliefs when you don’t even know me- I suspect you have never even read a single one of my 100+ scientific papers on cancer research or even read my substack articles on the topic. There is nothing stronger than the scientific method- when done rigorously, honestly and with integrity. It does start with a question, and from reading the literature with my background on environmental exposures and cancer as well as HPV- associated cancers the question was…. I wonder if the exposure to a novel virus that’s is impacting the immune system in atypical ways might be associated with cancer? The virus induces immune dysfunction.Data shows spike protein interacts with key tumor suppressor genes. And you know what else encodes for spike and induces immune dysfunction- the vaccines do. So go read my review on the subject. This is not a belief- this is the scientific method in action! Based on how you communicate with me and other colleagues and the content of your posts, you clearly are not a serious person and maybe it’s time you sit this one out and let those of us who want to champion evidence generation take the lead.
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
🧐 The new Linked Discoveries tool accessible through PubMed seeks to help scientists explore how individual research findings relate to the larger body of biomedical evidence. It is a direct reflection of our agency’s commitment to strengthening replication and reproducibility in NIH-funded research.
NEWS: NIH launches new resource accessible through PubMed to strengthen research replication and reproducibility. Read the full story ➡️ bit.ly/4y7rXtA
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
Celebrating World Cancer Research Day #WCRD2026 at the @UICC #WCC2026 in Hong Kong with colleagues from around the globe. @ASCOPres @EnriqueSoto8 @cspramesh @AORTIC_AFRICA @ManjuSengar7 @ASCO @ajumathew_
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
BREAKING: Google launching TPUs in space NEXT WEEK on SpaceX falcon 9 to test AI data centers orbit ITS HAPPENING
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
Online Now: γδ T cells modulate anti-tumor immunity in small cell lung cancer dlvr.it/TVdZ7z
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
ZB Mic'd Up for Sunday's THRILLING win
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
Excited to share our new paper, out today in @ScienceMagazine! We developed senescence-modulating nanoparticles (SMNPs) that target P-selectin+ pathogenic senescent-like macrophages in fibrotic tissues and tumors. science.org/doi/10.1126/scie…
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Lovely evening at the home of Professor John Reed Smith who has been teaching our accounting class at the @KelleyBizMed IU Kelley School of Business Physician MBA Program this semester. My current cohort for the Class of 2028, the second year class of 2027 and the alumni are an incredible physician force for the transformation of healthcare, entrepreneurship, biotechnology, and more. Very glad to participate at a pace that works with my very busy schedule. I have met some amazing people. Thanks to Susannah Eastwick the program director as well. Reed is a wine connoisseur with an amazing collection and he shares with his students interesting wine tidbits at the beginning of every weekly nighttime class. I am usually scrambling to get ready for the weekly evening zoom sessions class, videos, pre-reading material but look forward to a time when I can study the wine selections more because they are competitive with the best the world has to offer. lnkd.in/p/gpJ9ek_z
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Wafik S. El-Deiry, MD, PhD, FACP retweeted
🚀 Our landmark study in npj Genomic Medicine shows better outcomes when cancer biology is well-matched: survival doubled (OS 18.7 vs 9.0 mo; HR 0.54, P=0.003) in multivariate analysis validating @CureMatch Score👇Link in comments
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