The Lab for NeuroImaging of Coma and Consciousness is dedicated to promoting recovery from severe brain injury.
Massachusetts General Hospital
Based in United States
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Two new tools to map the human brainstem:
nuclei: onlinelibrary.wiley.com/doi/…
bundles: pnas.org/doi/10.1073/pnas.25…
code: surfer.nmr.mgh.harvard.edu/f…
github.com/markolchanyi/BSBT
@olchanyi @JuanEugenioIgl1 @MGHMartinos @MGH_CNTR @MGBResearchNews @MIT
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Visualizing Effective Connectivity in the Human Brain
Preprint: biorxiv.org/content/10.1101/…
Code: github.com/ComaRecoveryLab/S…
YouTube video: piped.video/V0hqs-noYNg
Download video & figures: zenodo.org/records/14974861
Led by #XanderAtalay & #TeoFecchio
@MGH_CNTR @MGHMartinos @MGHNeuroICU
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Is it appropriate to share clinically relevant research results with active-duty Special Operations Forces?
We explore ethical, legal & operational perspectives, with the goal of empowering Operators who seek information about their brain health.
osf.io/preprints/psyarxiv/v6…
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We mapped the subcortical hubs of brain networks that sustain consciousness to provide therapeutic targets for patients with severe brain injuries.
preprint: biorxiv.org/content/10.1101/…
hub maps: github.com/ComaRecoveryLab/S…
@MorganCambareri @andrewli1127 @andreashorn_ @lauradata
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To advance the study of coma & consciousness, we created a @FreeSurferMRI algorithm that automatically identifies brainstem nuclei in MRI scans.
preprint:medrxiv.org/content/10.1101/…
code:surfer.nmr.mgh.harvard.edu/f…
@olchanyi @JuanEugenioIgl1 @MGHMartinos @MGH_RI @MGH_CNTR @MIT_IMES
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An inspiring week of discussions, presentations, and strategy sessions about how to improve health care for the Special Operations Forces community.
Thank you @NavySEALfnd for your vision and leadership.
This week, we're hosting the 7th Annual Navy SEAL Foundation Impact Forum in DC, focusing on collaboration, communication, and education. It’s a opportunity for networking and learning, aimed at enhancing behavioral health services for the military and community.
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An inspiring week of discussions, presentations, and strategy sessions about how to improve health care for the Special Operations Forces community.
Thank you @NavySEALfnd for your vision and leadership.
This week, we're hosting the 7th Annual Navy SEAL Foundation Impact Forum in DC, focusing on collaboration, communication, and education. It’s a opportunity for networking and learning, aimed at enhancing behavioral health services for the military and community.
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Harvard Ascending Arousal Network Atlas v2.0 now available at datadryad.org/stash/dataset/…
Updates based on new immunohistochemistry data available at histopath.nmr.mgh.harvard.ed…
Details provided in Supplementary Material at science.org/doi/10.1126/scit…
@MGHMartinos @MGHNeurology @leaddbs
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In addition, we release histology and immunohistochemistry data for the 3 human brain specimens:
histopath.nmr.mgh.harvard.ed…
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Brainstem connections that sustain wakefulness in human consciousness: science.org/doi/10.1126/scit…
Thank you @ScienceTM for featuring this work on the cover!
@MGH_CNTR @MGH_RI @MassGeneralNews @MGHNeuroICU @MGHNeuroSci @MGHNeurology @MGHMartinos @BostonChildrens @MIT @BWHNeurology
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Increased blast exposure was also associated with decreased self-reported quality of life in active-duty Special Operations Forces.
None of the findings changed when PTSD symptoms were added to the statistical models.
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Rostral anterior cingulate cortex (rACC) is a hub node in the frontal lobe that connects the executive control, salience, and default mode networks.
rACC may be susceptible to blast waves that penetrate the openings in the skull behind the eyes.
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In 30 active-duty US Special Operations Forces, higher blast exposure was associated with alterations in brain structure, function & neuroimmune markers: pnas.org/doi/10.1073/pnas.23…
Imaging findings converged at rostral anterior cingulate cortex, which modulates cognition & emotion.
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Impact of Repeated Blast Exposure in Active-Duty U.S. Special Operations Forces: pnas.org/doi/10.1073/pnas.23…
We thank the 30 SOF participants, who bring the military one step closer to a diagnostic test for repeated blast brain injury.
@MGHNeurology @MGHMartinos @MGH_CNTR
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Most fun part of science is getting to collaborate with wonderful friends and colleagues.
#LETBI #ENRICH #NEW_HOPE_TBI
@MGH_CNTR @MGHNeuroSci @MGHMartinos @SinaiTBI @UWNeuropath
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@EricGoralnick representing for @MassGenBrigham at #ArmyNavyGame2023
@MassGeneralNews @BrighamWomens @SpauldingRehab @homebaseprogram
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Fascinating @MGHNeuroSci Grand Rounds by @nastasiayendiki on state-of-the-science in brain circuit mapping.
Captivating @MGHMartinos Connectome 2.0 data suggest future integration of mesoscale connectome and microscale synaptome.
@GLlorden @SusieHuangMDPhD @MGH_RI @MGHImaging
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@MGBInnovation panel on workforce development for Veterans and their families. Highlighting importance of providing civilian opportunities that match Veterans' talents and skills.
Gratitude to organizations like #SOF2SOM who are leaders in this space: sof2som.org
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@MGBInnovation panel on innovations in patient care for military Service Members, Veterans, and their families. Part of a moving and inspiring Veteran's Day Program at Mass General Brigham.
@homebaseprogram @DeptVetAffairs @MGH_RI @MassGeneralNews @MGHNeuroSci @MGH_CNTR
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@USUhealthsci @MassGenBrigham sign a statement of intent to collaborate across 3 key initiatives:
1) work force development
2) education
3) research
Thank you @EricGoralnick for your leadership!
@MGH_RI @BrighamWomens @MassGeneralNews #MGHCIDH @homebaseprogram @SpauldingRehab
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We mapped the connectivity of brainstem pathways that sustain human consciousness. A decade in the making...
Preprint: biorxiv.org/content/10.1101/…
Ex vivo MRI: openneuro.org/datasets/ds004…
Histology: histopath.nmr.mgh.harvard.ed…
Atlas: datadryad.org/stash/dataset/…
Code: github.com/ComaRecoveryLab/N…
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Marty Samuels was an inspiration, mentor, colleague and friend to generations of neurologists. The consummate clinician-educator. So kind and thoughtful.
We will miss you and never forget you or the impact that you had on all of us.
@BWHNeurology @MGHNeurology
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What is the best test to detect consciousness in the ICU? Behavioral exam? fMRI? EEG? Or is it TMS-EEG?
We discuss the potential for TMS-EEG measurements of brain complexity to improve care for patients with severe brain injuries in the ICU.
link.springer.com/article/10…
@CuringComa
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Packed house not only in the #EtherDome but also in the @MGHNeuroICU conference room for @NINDSdirector #WalterKoroshetz Grand Rounds.
Inspiring talk about history of neurology and how we are entering a golden era in neuroscience.
@MGH_CNTR @MGHNeurology @MGHMartinos @MGH_RI
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Fascinating @MGHNeurology Grand Rounds by #ChrisGiza @griz1 on pediatric TBI, advances in diagnostic and prognostic biomarkers for TBI, and future directions to treat post-traumatic cognitive, physical, and psychological symptoms.
@MghPediNeuro @MGH_CNTR @MGHNeuroICU
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Inspiring talks by families who donated loves ones' brains to TBI research, and by researchers who honor their memory by studying their brains.
@UWNeuropath @SinaiTBI @MGHMartinos @MGH_CNTR @DamsOConnor @AmberNolan_ #ChristineMacDonald #DirkKeene
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Such an honor to get to hang out with two giants in our field. Thank you @romergeocadin & #TomBleck for your mentorship and support.
#ANA2022 @CuringComa @neurocritical @MGHNeuroICU @MGH_CNTR
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Dr. Lauren Brenner and Dr. Sharmin Ghaznavi give keynote addresses at @NavySEALfnd 2022 IMPACT Forum. Where we are and where we need to go to optimize brain health for military personnel and veterans.
@homebaseprogram @MGHNeuroSci @MGHPsychiatry @SpauldingRehab @MGH_RI @USSOCOM
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@YelenaBodien & #JoeGiacino teaching at #NABIS about the Coma Recovery Scale-Revised - a tool that has revolutionized behavioral assessment of patients with disorders of consciousness worldwide.
@CuringComa @MGH_CNTR @MGHNeuroICU @SpauldingRehab
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@melanieboly highlights recents results from @SamBSnider @dbfisch @foxmdphd @EdAmorimMD #MattBevers indicating that the "contents of consciousness" (awareness) are in posterior regions of the brain. @NeuroscienceSAS @CuringComa @MGHNeuroICU @BWHNeuroICU
n.neurology.org/content/98/1…
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@CharlottMaschke explains how electrophysiologic responses of the injured brain to propofol sedation in the #ICU may predict subsequent recovery.
@NeuroscienceSAS @CuringComa @BlainMoraes @CatherineDuclo6 @mcgillu
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Remarkable consistency across labs and modalities: 15-20% of patients who appear unresponsive show covert consciousness on task-based fMRI & EEG, and #MarcelloMassimini reports that 20% have high brain complexity (capacity for consciousness) on TMS-EEG.
@NeuroscienceSAS
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#MarcelloMassimini explains how consciousness requires integration and specialization of electrical signaling within the brain
Perturbation of the brain with TMS-EEG provides insights that cannot be made with resting-state measures
@NeuroscienceSAS @CuringComa @tbd_foundation
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Lucia Melloni @MPI_ae describes a hierarchical EEG-based protocol designed to detect language perception & comprehension in unresponsive patients.
Recently tested in the ICU: onlinelibrary.wiley.com/doi/…
What diagnosis do we give to these patients?
@NeuroscienceSAS @CuringComa
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Insights into neural correlates of #consciousness by @melanieboly at Neuroscience School of Advanced Studies @NeuroscienceSAS #Venice
@theASSC @CuringComa @tbd_foundation
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To fMRI or Not to fMRI? #MartinMonti presenting on clinical implementation of advanced diagnostic techniques, consistent with the 2018 @AANMember Clinical Guidelines on Disorders of Consciousness. #AANAM #AAN @CuringComa
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#COVID19 clinicians & researchers: do you have access to clinical MRI scans from patients with #COVID19? A new method by @JuanEugenioIgl1 allows you to synthesize high-res, 1mm isotropic, research-quality MRI data from low-res clinical MRI data:
medrxiv.org/content/10.1101/… [1/3]
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How should we counsel families whose loved ones survive severe COVID-19 but remain unconscious for days-weeks?
Outcome data are limited, but emerging evidence indicates that long-term recovery is possible. rdcu.be/czu2I
@dbfisch @CuringComa
figshare.com/articles/media/…
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The NeuroEthics of Disorders of Consciousness: A Brief History of Evolving Ideas
@MJYoung_MD et al review how #coma and #consciousness have been conceptualized by philosophers, ethicists, neuroscientists, and clinicians, and where we go from here: academic.oup.com/brain/advan…
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To support development of targeted neuromodulatory therapies, we mapped the subcortical connectivity of the human default mode network.
Project led by @AndrewLi1127 with @HumanConnectome 7T fMRI data. Data released at @leaddbs & @OpenNeuroOrg. Preprint at biorxiv.org/content/10.1101/…
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A mentor and hero to generations of neurologists. A master clinician, brilliant researcher, and kind human being. Beloved friend and colleague. You will be missed #VerneCaviness
@MGHNeurology @MGHNeuroSci @MGHMartinos @MGH_CNTR @MGH_RI @MGHImaging @MGHNeuroICU @harvardneuromds
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So excited for @EdlowLab, who published more groundbreaking work on COVID-19 that is relevant to pregnant & lactating women worldwide. Also pretty cool to see this work get the attention it deserves as the top story on CNN! @AJOG_thegray
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Fascinating brain mapping talks from around the world at the #5thWorldAnnualCourseOnBrainMapping. Thanks to @gsamandouras for organizing this global event. Legendary neurosurgeon #GeorgeOjemann giving closing talk now! #IamBrain
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Fascinating @MGHNeurology Grand Rounds by @SherryChou399 on neurological manifestations of #COVID19. Many unanswered questions re prevalence and mechanisms. Global studies, including #GCSNeuroCOVID, hope to provide answers...
@EANeurology @CuringComa @NeuroCov @NEUROCOVID19
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Thank you to all the scientists who developed the vaccine and to all the people who volunteered for the vaccine trials. Thinking of the many patients with #COVID19 who didn’t live to see this moment. #BeginningOfTheEnd
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Brainstem-to-thalamus connectivity increases in patients who recover consciousness after traumatic coma. New study led by @SamBSnider. Diffusion MRI data released at openneuro.org/datasets/ds003…
sciencedirect.com/science/ar…
@MGH_CNTR @MGHMartinos @MGH_RI @MGHNeurology
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