The Lab for NeuroImaging of Coma and Consciousness is dedicated to promoting recovery from severe brain injury.
Massachusetts General Hospital
Based in United States
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Grateful for support from:
@ChenInstitute @JSMF @RappFoundation @NINDSfunding @DeptofWar @NIBIBgov @NIMHDirector @ABFbrain @HumanConnectome
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Two new tools to map the human brainstem:
nuclei: onlinelibrary.wiley.com/doi/…
bundles: pnas.org/doi/10.1073/pnas.25…
code: surfer.nmr.mgh.harvard.edu/f…
github.com/markolchanyi/BSBT
@olchanyi @JuanEugenioIgl1 @MGHMartinos @MGH_CNTR @MGBResearchNews @MIT
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Congratulations to @bu_cte @BU_Tweets @VABostonHC on this landmark contribution to the field of chronic traumatic encephalopathy (CTE):
nature.com/articles/s41586-0…
Elegant and groundbreaking work, with substantial public health implications.
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Visualizing Effective Connectivity in the Human Brain
Preprint: biorxiv.org/content/10.1101/…
Code: github.com/ComaRecoveryLab/S…
YouTube video: piped.video/V0hqs-noYNg
Download video & figures: zenodo.org/records/14974861
Led by #XanderAtalay & #TeoFecchio
@MGH_CNTR @MGHMartinos @MGHNeuroICU
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A traumatic microbleed on MRI does not reliably indicate "hemorrhagic DAI".
It indicates vascular injury, which is dissociated from axonal injury ~35% of the time.
The dissociation btwn microbleeds and axonal injury may explain reports of recovery from grade 3 hemorrhagic DAI.
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For years, many of us used traumatic microbleeds on MRI to prognosticate in the ICU for pts w/ severe TBI.
We assumed microbleed = axonal injury.
This assumption was incorrect: medrxiv.org/content/10.1101/…
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Is it appropriate to share clinically relevant research results with active-duty Special Operations Forces?
We explore ethical, legal & operational perspectives, with the goal of empowering Operators who seek information about their brain health.
osf.io/preprints/psyarxiv/v6…
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We mapped the subcortical hubs of brain networks that sustain consciousness to provide therapeutic targets for patients with severe brain injuries.
preprint: biorxiv.org/content/10.1101/…
hub maps: github.com/ComaRecoveryLab/S…
@MorganCambareri @andrewli1127 @andreashorn_ @lauradata
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Incredibly elegant and impactful work. Potential to help many Veterans with PTSD.
Congratulations @shansiddiqi @foxmdphd and team.
Out @NatureNeuro: Network localization of brain stim targets for PTSD.
TLDR: Lesions connected to this circuit REDUCE risk of PTSD in Vets. Also tested with fMRI and TMS.
Free link: rdcu.be/dUVTY
With @foxmdphd @NoahSPhilipMD @davidcarreon @AArulpragasam @MoreyLab
ALT Link: https://rdcu.be/dUVTY
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Study led by @olchanyi @JuanEugenioIgl1
Grateful to @NINDSdirector @NIHDirector @NIBIBgov @DeptofDefense @NIMHgov @NIHAging @ERC_Research @MIT @JSMF @ChenInstitute @RappFoundation #MITTakeda #BASCIC for support.
Thank you @HumanConnectome #ADNI for publicly available data.
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To advance the study of coma & consciousness, we created a @FreeSurferMRI algorithm that automatically identifies brainstem nuclei in MRI scans.
preprint:medrxiv.org/content/10.1101/…
code:surfer.nmr.mgh.harvard.edu/f…
@olchanyi @JuanEugenioIgl1 @MGHMartinos @MGH_RI @MGH_CNTR @MIT_IMES
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An elegant new registration method that leverages fMRI data: sciencedirect.com/science/ar…
Congratulations @andrewli1127 on this groundbreaking work, with @AdrianDalca @MGHMartinos @FreeSurferMRI.
@MGH_CNTR @MGHImaging @MGHNeuroSci
Does registration of folding patterns always do a good job of aligning brain function? Thrilled to share our work #JOSA, a joint spherical #registration method that uses functional data to drive registration to achieve superior performance in geometric and functional registration
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This is a remarkable tool that will move our field forward. Mind-blowing that this is even possible. Congratulations @FangChengYeh!
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Congratulations @dbfisch & team at @PennNeurology on groundbreaking work to improve the accuracy of neuroprognostication and quality of care for patients with disorders of consciousness and their families.
neurology.org/doi/full/10.12…
@CuringComa @neurocritical @CDOCuk @MGHNeuroICU
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Covert Consciousness in the ICU
A review in collaboration with @Menon_Cambridge
Thank you @CritCareMed for highlighting this topic, now even more relevant after yesterday's @NEJM paper (nejm.org/doi/full/10.1056/NE…)
journals.lww.com/ccmjournal/…
@MGHNeuroICU @MGHNeuroSci @MGHNeurology
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How many patients with severe brain injuries have we examined who appeared unresponsive, and we assumed they were unconscious?
International @JSMF study in @NEJM suggests that 25% were covertly conscious: nejm.org/doi/full/10.1056/NE…
Profound clinical & ethical implications...
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Congratulations @karnig_kazazian on this review in @TheLancetNeuro
Detecting awareness after acute brain injury
thelancet.com/journals/laneu…
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The brave men and women of the Special Operations Forces community deserve the best possible medical care.
Some ideas for how to make that happen, starting with a reliable diagnostic test for repeated blast brain injury: defenseopinion.com/better-br…
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Thank you @NIHDirector Dr. Bertagnolli for highlighting this brain mapping study by @MGH_CNTR @MGHNeurology @MGHMartinos @MIT @BostonChildrens
Grateful for support from @NINDSdirector @NIBIBgov @NICHD_NIH @NIHAging @NIMH @NIH BRAIN Initiative.
directorsblog.nih.gov/2024/0…
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