This! Bullseye by @SahilBloom

Decoding systemic vascular health and hypertensive disorders in pregnancy through retinal imaging and Visionary AI nature.com/articles/s41587-0…

This is not true. This just makes people doubt peptides more. This is not a human study and very specific case in rodents. State the facts to explain your point

BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

Slowing aging by just one year would add ~$400B per year to U.S. GDP. Slowing it by five years would add $2T - more than twice the annual U.S. defense budget. In 2024, the U.S. federal government spent roughly $2.6T on Social Security and Medicare (about 38% of total federal spending), and most of it was concentrated on older adults 65+. By 2029, this spending will grow to $3T every year. This structural and fiscal pressure of aging creates economic opportunity where even a small shift in biological aging could be transformative.

This is hopefully the future

What happens when your patient is better at using AI than you are? Her Longevity tomorrow: women’s health + longevity, then me on AI across medicine at 5:19 PM. Hopefully you’re still awake 😂 NYC/virtual yourlongevity.ticketspice.co… Code: 100off

New research suggests that “skin aging” may not be one single process. Scientists developed 2 different epigenetic clocks for skin: • One measures endogenous aging — aging driven from inside the body. • The other measures exogenous aging — damage driven by outside exposures like sunlight. Sun-exposed skin looked older on the exogenous clock, which makes sense. But here’s the interesting part: Sun exposure did not significantly accelerate the endogenous skin-aging clock. Even more surprising, one collagen-related gene, COL1A1, seemed to decline less with age in sun-exposed skin than in protected skin. That does NOT mean UV is “anti-aging.” But it does suggest the story may be more complicated than: “Sunlight simply makes skin age faster.” It may be possible for sunlight to increase photoaging in one pathway while having neutral—or even potentially protective/adaptive—effects in another. In other words: Photodamage and biological aging may overlap, but they are not necessarily the same thing. That’s a very interesting idea worth studying further. link.springer.com/article/10…

Continuous positive airway pressure (CPAP) is the best-known treatment for sleep apnea, a disorder that raises the risk of high blood pressure and other health problems. A new study suggests that using a mandibular advancement device (MAD) is just as effective as CPAP for reducing blood pressure in people with sleep apnea at risk for cardiovascular disease. #HarvardHealth buff.ly/Rk6SZmP

The FDA cleared a robot that performs joint ultrasounds and writes the report itself. @ROPCA3's Arthur scans fingers/hands/wrists for arthritis; its AI, Diana, reads them. 72% of US counties have zero rheumatologists. Translation: the scan and the first read move from a scarce specialist to a machine buff.ly/W68NJ2g #HealthTech #Rheumatology #AI

A new treatment for endometriosis — a painful, chronic condition that around 190 million people live with — might be on the horizon. go.nature.com/4iSD590

NEW: A next-generation weight-loss drug from Eli Lilly, when combined with Zepbound, helped people lose substantially more weight than Zepbound alone, according to a new study wsj.com/health/pharma/lillys… via @WSJ

🚨 Lilly may have just topped retatrutide. Eloralintide 9 mg + tirzepatide 15 mg: 29% average weight loss at 31 weeks. For context, retatrutide 12 mg produced 28.3% at 80 weeks in Phase 3 TRIUMPH-1. Huge caveat: this was a tiny Phase 1b study, not a head-to-head trial. But 29% in 31 weeks is a WILD efficacy signal. $LLY $NVO

Please help those who need it

If myelin really is the brain’s proton capacitor then nnEMFs could be draining the charge before it even builds Maybe that’s why so many people wake up tired even after 8-9 hours of sleep You can’t recharge a system that never gets to hold its charge. ELECTRICAL DEBT

🚨 It’s finally out! The video that explains clearly what we believe is happening when infrared light hits the mitochondria. It’s worth the whole watch! How Infrared Light Actually Affects Your Mitochondria - Hypothesis youtu.be/ID5k4G3ogqM

GLP1 RAs reduce inflammation in multiple disease models by affecting IL1β, IL6, TNFα, ands the NLRP3 inflammasome. These actions help explain benefits beyond glucose control and weight loss. academic.oup.com/jcem/articl…

A first important step

Can oral peptides work? Yes. KPV uses PEPT1. BPC-157 may work locally in the gut. Oral semaglutide uses SNAC to increase absorption into the bloodstream. “Peptides get destroyed in the gut, so oral peptides can’t work” is too simplistic. Full podcast in replies 👇

Pharma R&D is shifting toward AI-guided, increasingly automated discovery. Tariffs and supply chain pressure are driving $400B+ in US manufacturing and R&D investment, creating a reset moment for lab design and a major testbed for AI.